1,478 Result(s)

Article

Study on the effects of rapamycin and the mTORC1/2 dual inhibitor OSI-027 on the metabolism of colon cancer cells based on UPLC-MS/MS metabolomics

mTORC1/2 dual inhibitors may be more effective than mTORC1 inhibitor rapamycin. However, their metabolic impacts on colon cancer cells remain unexplored. We conducted a comparative analysis of the anti-prolife...

Kai Fan, Yueyuan Wang, Jiangyu**g Bian, Yewen Sun, Jiaqi Dou… in Investigational New Drugs (2024)

Article

Response to article “Anxiety, depression, urinary continence, and sexuality in patients undergoing radical prostatectomy: preliminary findings”

Song Wang, Pan Shu, **ao-Lian Jiang in Supportive Care in Cancer (2024)

Article

Cinnamaldehyde Regulates the Migration and Apoptosis of Gastric Cancer Cells by Inhibiting the Jak2/Stat3 Pathway

Gastric cancer is a malignant tumor with high morbidity and mortality all around the world. Because of its poor prognosis and low survival rate, the treatment of gastric cancer has received extensive attention...

Yuan-yuan Geng, Shuo Yang, Zhi-hao Liu, Si-yu Wang… in Digestive Diseases and Sciences (2024)

Article

An evaluation model of hepatic steatosis based on CT value and serum uric acid/HDL cholesterol ratio can predict intrahepatic recurrence of colorectal cancer liver metastasis

Intrahepatic recurrence is one of the main causes of treatment failure in patients with colorectal cancer liver metastasis (CRLM). Hepatic steatosis was reported to provide fertile soil for metastasis. The eff...

Yuan Li, E-er-man-bie-ke **-si-han… in International Journal of Clinical Oncology (2024)

Article

Reduced intensity conditioning regimen of fludarabine, busulfan, ATG based haploidentical stem cell transplantation for older or unfit patients

Reduced-intensity conditioning (RIC) regimens allogeneic hematopoietic stem cell transplantation (HSCT) was developed for older patients or those with poor functional status. Haploidentical donor was appropria...

Mingyue Pan, Yibo Wu, Luxin Yang, Panpan Zhu, Jimin Shi, **aoyu Lai… in Annals of Hematology (2024)

Article

Restoring BARX2 in OSCC reverses partial EMT and suppresses metastasis through miR-186-5p/miR-378a-3p-dependent SERPINE2 inhibition

Tumor cells undergoing partial epithelial-mesenchymal transition (pEMT) are pivotal in local invasion and lymphatic metastasis of oral squamous cell carcinoma (OSCC), yet the mechanisms behind pEMT reversal re...

Yanan Sun, Junchen Pan, Yiwei Li, Yaying Hu, Jiyuan Ma, Fu Chen, Yuying Zhang… in Oncogene (2024)

Article

Using Vision Transformer for high robustness and generalization in predicting EGFR mutation status in lung adenocarcinoma

Lung adenocarcinoma is a common cause of cancer-related deaths worldwide, and accurate EGFR genoty** is crucial for optimal treatment outcomes. Conventional methods for identifying the EGFR genotype have sev...

Luoqi Weng, Yilun Xu, Yuhan Chen, Chengshui Chen… in Clinical and Translational Oncology (2024)

Article

Thrombin receptor activating peptide-6 decreases acute graft-versus-host disease through activating GPR15

G-protein coupled receptor 15 (GPR15) is expressed on T-cells. We previously reported knockout of GPR15 increased acute graft-versus-host disease (GvHD) in mice. In this study, we identified thrombin receptor act...

Cong Liu, Qiu Lan, Shuo Cao, Fei Zheng, Yiwen Liang, **gyi Shen, Ying Wang… in Leukemia (2024)

Article

Inherited KDM6A^A649T facilitates tumor-immune escape and exacerbates colorectal signet-ring cell carcinoma outcomes

Childhood onset of colorectal signet-ring cell carcinoma (CR-SRCC) is extremely rare and featured as highly malignant with poor prognosis. Here we reported a CR-SRCC case of 11-year-old boy with a novel inheri...

Maoxiao Feng, Chengwei Chai, **aodong Hao, **aojiang Lai, Yuanyuan Luo… in Oncogene (2024)