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Article
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Fernando Rivadeneira and colleagues in the Genetic Factors for Osteoporosis Consortium report a large-scale meta-analysis identifying new loci associated with bone mineral density (BMD) and risk of fracture. T...
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Article
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
Martin Tobin and colleagues report a meta-analysis of 23 genome-wide association studies for pulmonary function. They identify 16 loci newly associated with variation in two cross-sectional measures of lung fu...
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Article
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
Ruth Loos and colleagues use genome-wide association to identify common variants influencing body fat percentage. Unexpectedly, they show that a body-fat–decreasing allele near IRS1 is associated with an impaired...
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Article
Open AccessAKT1 polymorphisms are associated with risk for metabolic syndrome
Converging lines of evidence suggest that AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cel...
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Development and Validation of a Nutritional Education Pamphlet for Low Literacy Pediatric Oncology Caregivers in Central America
A culturally appropriate nutrition education pamphlet was developed and validated for low-literacy caregivers in Honduras, El Salvador, and Guatemala. The pamphlet was developed after a preliminary survey of p...
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Article
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
Ken Ong and colleagues report meta-analysis of 32 genome-wide association studies for age at menarche. They identify 30 loci newly associated with age at menarche, including four that were previously associate...
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Article
Open AccessA polymorphism near IGF1 is associated with body composition and muscle function in women from the Health, Aging, and Body Composition Study
Previous studies have reported associations of polymorphisms in the IGF1 gene with phenotypes of body composition (BC). The purpose of this study was to identify phenotypes of BC and physical function that were a...
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Article
Meta-analysis of genome-wide association data identifies two loci influencing age at menarche
André Uitterlinden and colleagues report loci at 9q31.2 and LIN28B associated with age at menarche from a meta-analysis of genome-wide association studies including 17,510 females from eight different population-...
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Implementing the centers for disease control and prevention’s Early Aberration Reporting System (EARS): A frontline perspective from the knox county, Tennessee, health department