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Article
Open AccessA new type of protein chip to detect hepatocellular carcinoma-related autoimmune antibodies in the sera of hepatitis C virus-positive patients
We report here a new type of protein chip to detect antibodies in sera. This chip method was used to a prototype created to detect hepatocellular carcinoma (HCC) -related autoantibodies in the sera of hepatiti...
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Article
Open AccessGermline copy number variations associated with breast cancer susceptibility in a Japanese population
Although copy number variations (CNVs) are expected to affect various diseases, little is known about the association between CNVs and breast cancer susceptibility. Therefore, we investigated this relation. Ar...
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Chapter and Conference Paper
Strategy-Proof Mechanisms for the k-Winner Selection Problem
The goal of this paper is to develop a strategy-proof (SP) mechanism for the k-winner selection problem, which finds a set of (at most) k winners among participants. Here, we assume the winners can have positive/...
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Article
Open AccessLuminal A and luminal B (HER2 negative) subtypes of breast cancer consist of a mixture of tumors with different genotype
The St Gallen International Expert Consensus 2011 has proposed a new classification system for breast cancer. The purpose of this study was to elucidate the relationship between the breast cancer subtypes dete...
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Article
Impact of surgical site infection after colorectal surgery on hospital stay and medical expenditure in Japan
To clarify the impact of surgical site infection (SSI) after colorectal surgery on the length of hospital stay and medical expenditure in Japan.
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Article
Prospective ultrasonographic prediction of sentinel lymph node metastasis by real-time virtual sonography constructed with three-dimensional computed tomography–lymphography in breast cancer patients
Real-time virtual sonography (RVS) systems display virtual multiplanar reconstruction (MPR) images obtained from three-dimensional (3D) computed tomography (CT)–lymphography (LG), significantly improving preop...
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Article
Immuno- and gene-therapeutic strategies targeted against cancer (mainly focusing on pancreatic cancer)
Current treatment modalities of surgical resection and chemotherapy against cancers have improved survival. However, mortality from tumor recurrence remains high. Immunotherapy and gene therapy are potential a...
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Article
Open AccessBreast cancer cell lines carry cell line-specific genomic alterations that are distinct from aberrations in breast cancer tissues: Comparison of the CGH profiles between cancer cell lines and primary cancer tissues
Cell lines are commonly used in various kinds of biomedical research in the world. However, it remains uncertain whether genomic alterations existing in primary tumor tissues are represented in cell lines and ...
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Article
The effect of adjuvant and neoadjuvant chemo(radio)therapy on survival in 1,679 resected pancreatic carcinoma cases in Japan: report of the national survey in the 34th annual meeting of Japanese Society of Pancreatic Surgery
Pancreatic carcinoma causes more than 20,000 deaths every year in Japan. The role of (neo-) adjuvant chemotherapy for pancreatic carcinoma is still controversial.
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Article
Improvement of early delayed gastric emptying in patients with Billroth I type of reconstruction after pylorus preserving pancreatoduodenectomy
Early delayed gastric emptying (DGE) is the most common complication after pylorus-preserving pancreatoduodenectomy (PpPD). Recently, a vertical antecolic reconstruction for duodenojejunostomy was recommended ...
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Article
Involvement of c-myc-regulated genes in hepatocellular carcinoma related to genotype-C hepatitis B virus
Purpose: The purpose of this study was to elucidate the molecular basis of hepatocellular carcinoma (HCC) caused by genotype-C hepatitis B virus (HBV). Methods: We compared molecular prof...
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Article
Current antibiotic prophylaxis in pancreatoduodenectomy in Japan
The aim of this study was to investigate the current use of antibiotic prophylaxis (AP) in association with pancreatoduodenectomy (PD) in Japan, and to determine its surgical implications.
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Article
Increased expression of MUC1 in advanced pancreatic cancer
MUC1 is associated with tumor invasion and metastasis, and is expressed in pancreatic cancer with a high frequency. This study explored whether MUC1 expression affected the survival of patients with pancreatic...
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Article
Differential gene expression in distinct virologic types of hepatocellular carcinoma: association with liver cirrhosis
Using oligonucleotide microarray data of 45 hepatocellular carcinoma (HCC) samples, we evaluated gene expression in hepatitis B virus-positive and hepatitis C virus-positive HCCs (HBV- and HCV-HCCs) for an ass...
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Article
Facilitation of adenoviral wild-type p53-induced apoptotic cell death by overexpression of p33ING1 in T.Tn human esophageal carcinoma cells
To investigate the effect of p33ING1 on wild-type p53 gene therapy, T.Tn human esophageal carcinoma cells were stably transfected with p33ING1 cDNA. Infection with Ad-p53 (recombinant adenovirus containing wild-t...
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Chapter and Conference Paper
Mediastinoscopy-Assisted Transhiatal Esophagectomy: A Safe Technique for Squamous Cell Carcinoma of the Esophagus
Esophagectomy with lymphadenectomy has improved the survival of patients with esophageal cancer [1, 2]. The morbidity and mortality associated with transthoracic (abdominothoracic) esophagectomy (TTE) is substant...
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Article
Successful immunogene therapy using colon cancer cells (colon 26) transfected with plasmid vector containing mature interleukin-18 cDNA and the Igκ leader sequence
IL-18 is a novel cytokine that induces interferon (IFN)-γ secretion and plays an important role in antitumor immunity. In the present study, we constructed plasmid vectors encoding the murine mature IL-18 cDNA...
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Chapter and Conference Paper
Surgical Treatment of Hepatocellular Carcinoma
Hepatic resection is currently performed for the treatment of hepatocellular carcinoma (HCC), which is associated with a high incidence of postoperative recurrence. The aim of this study was to clarify the pro...
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Article
A rapid PCR-aided selection of a rice line containing the Rf-1 gene which is involved in restoration of the cytoplasmic male sterility
Cytoplasmic male sterility (CMS) is widely known in higher plants, the mechanism of which is believed to involve incompatibility between nuclei and cytoplasms. In rice lines with the CMS trait, fertility is re...
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Article
Compensatory hepatic hypertrophy after occlusion of branches of the portal vein or bile duct
The effect on the liver of portal or bile duct branch occlusion was examined in rabbits by measuring hepatic tissue blood flow and cellular kinetics, using the bromodeoxyuridine labeling index. The portal bran...
