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233 Result(s)
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Article
Open AccessCore clock gene BMAL1 and RNA-binding protein MEX3A collaboratively regulate Lgr5 expression in intestinal crypt cells
The intestinal epithelium is highly regenerative. Rapidly proliferating LGR5+ crypt base columnar (CBC) cells are responsible for epithelial turnover needed to maintain intestinal homeostasis. Upon tissue damage,...
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Open AccessThe relationship of exercise and cancer-related fatigue in patients with advanced liver cancer: a cross-sectional study
There is increasing interest in understanding exercise as a potential treatment for cancer-related fatigue (CRF); however, rarely research has been conducted on more aggressive cancers with short survival, suc...
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Open AccessNeuropathologist-level integrated classification of adult-type diffuse gliomas using deep learning from whole-slide pathological images
Current diagnosis of glioma types requires combining both histological features and molecular characteristics, which is an expensive and time-consuming procedure. Determining the tumor types directly from whol...
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Open AccessVisible light-triggered selective C(sp2)-H/C(sp3)-H coupling of benzenes with aliphatic hydrocarbons
The direct and selective coupling of benzenes with aliphatic hydrocarbons is a promising strategy for C(sp2)-C(sp3) bond formation using readily available starting materials, yet it remains a significant challeng...
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Open AccessElectronic Janus lattice and kagome-like bands in coloring-triangular MoTe2 monolayers
Polymorphic structures of transition metal dichalcogenides (TMDs) host exotic electronic states, like charge density wave and superconductivity. However, the number of these structures is limited by crystal sy...
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Open AccessMSFC: a new feature construction method for accurate diagnosis of mass spectrometry data
Mass spectrometry technology can realize dynamic detection of many complex matrix samples in a simple, rapid, compassionate, precise, and high-throughput manner and has become an indispensable tool in accurate...
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Open AccessReal-time and accurate estimation of surgical hemoglobin loss using deep learning-based medical sponges image analysis
Real-time and accurate estimation of surgical hemoglobin (Hb) loss is essential for fluid resuscitation management and evaluation of surgical techniques. In this study, we aimed to explore a novel surgical Hb ...
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Open AccessAuthor Correction: Numerical study of ice loads on different interfaces based on cohesive element formulation
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Open AccessA novel subspace outlier detection method by entropy-based clustering algorithm
Subspace outlier detection has emerged as a practical approach for outlier detection. Classical full space outlier detection methods become ineffective in high dimensional data due to the “curse of dimensional...
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Open AccessMyxobacteria restrain Phytophthora invasion by scavenging thiamine in soybean rhizosphere via outer membrane vesicle-secreted thiaminase I
Public metabolites such as vitamins play critical roles in maintaining the ecological functions of microbial community. However, the biochemical and physiological bases for fine-tuning of public metabolites in...
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Open AccessNumerical study of ice loads on different interfaces based on cohesive element formulation
With the increase of marine activities in the Arctic area, the demand for reliable design of marine structures is growing. Numerous publications can be found regarding simulations of ice action on structures u...
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Open AccessCharacterization and anti-inflammatory effect of selenium-enriched probiotic Bacillus amyloliquefaciens C-1, a potential postbiotics
A patented strain of Bacillus amyloliquefaciens C-1 in our laboratory could produce functional sodium selenite (Na2SeO3) under optimized fermentation conditions. With the strong stress resistance and abundant sec...
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Open AccessCancer-cell-secreted miR-204-5p induces leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia
Cancer-associated cachexia is a multi-organ weight loss syndrome, especially with a wasting disorder of adipose tissue and skeletal muscle. Small extracellular vesicles (sEVs) serve as emerging messengers to c...
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Open AccessPolyelectrolyte elastomer-based ionotronic sensors with multi-mode sensing capabilities via multi-material 3D printing
Stretchable ionotronics have drawn increasing attention during the past decade, enabling myriad applications in engineering and biomedicine. However, existing ionotronic sensors suffer from limited sensing cap...
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Open AccessElectrocatalyzed direct arene alkenylations without directing groups for selective late-stage drug diversification
Electrooxidation has emerged as an increasingly viable platform in molecular syntheses that can avoid stoichiometric chemical redox agents. Despite major progress in electrochemical C−H activations, these aren...
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Open AccessA global database for modeling tumor-immune cell communication
Communications between tumor cells and surrounding immune cells help shape the tumor immunity continuum. Recent breakthroughs in high-throughput technologies as well as computational algorithms had reported ma...
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Open AccessSatellite record reveals 1960s acceleration of Totten Ice Shelf in East Antarctica
Wilkes Land and Totten Glacier (TG) in East Antarctica (EA) have been losing ice mass significantly since 1989. There is a lack of knowledge of long-term mass balance in the region which hinders the estimation...
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Open AccessAssessing the effectiveness of targeted poverty alleviation policies in **njiang, China
To consolidate and expand the effective connection between the achievements of poverty alleviation in **njiang’s deeply impoverished areas and rural revitalization, it is necessary to study the effects and mec...
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Open AccessTPO as an indicator of lymph node metastasis and recurrence in papillary thyroid carcinoma
The objective of this study was to investigate the expression of thyroid peroxidase (TPO) in papillary thyroid carcinoma (PTC) and to preliminarily investigate its value as a marker of lymph node metastasis an...
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Open AccessAuthor Correction: Iontronic pressure sensor with high sensitivity over ultra-broad linear range enabled by laser-induced gradient micro-pyramids