3,154 Result(s)
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Open AccessUnveiling a new oceanic anoxic event at the Norian/Rhaetian boundary (Late Triassic)
The latest Triassic was characterised by protracted biotic extinctions concluding in the End-Triassic Extinction (~ 200 Ma) and a global carbon cycle perturbation. The onset of declining diversity is closely r...
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Open AccessNeuroprosthetic contact lens enabled sensorimotor system for point-of-care monitoring and feedback of intraocular pressure
The wearable contact lens that continuously monitors intraocular pressure (IOP) facilitates prompt and early-state medical treatments of oculopathies such as glaucoma, postoperative myopia, etc. However, eithe...
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Open AccessUnraveling the independent role of METTL3 in m6A modification and tumor progression in esophageal squamous cell carcinoma
METTL3 and METTL14 are traditionally posited to assemble the m6A methyltransferase complex in a stoichiometric 1:1 ratio, modulating mRNA fate via m6A modifications. Nevertheless, recent investigations reveal ...
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Open AccessSteady motion of 80-nm-size skyrmions in a 100-nm-wide track
The current-driven movement of magnetic skyrmions along a nanostripe is essential for the advancement and functionality of a new category of spintronic devices resembling racetracks. Despite extensive research...
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Open AccessResearch on the characteristics of electro-hydraulic position servo system of RBF neural network under fuzzy rules
A radial basis function neural network PID controller under fuzzy rules (FUZZY-RBF-PID) was designed for the electro-hydraulic position servo system under the influence of uncertain factors such as load mutati...
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Open AccessKAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2
Abnormal trophoblast self-renewal and differentiation during early gestation is the major cause of miscarriage, yet the underlying regulatory mechanisms remain elusive. Here, we show that trophoblast specific ...
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Open AccessBarbed arrow-like structure membrane with ultra-high rectification coefficient enables ultra-fast, highly-sensitive lateral-flow assay of cTnI
Acute myocardial infarction (AMI) has become a public health disease threatening public life safety due to its high mortality. The lateral-flow assay (LFA) of a typical cardiac biomarker, troponin I (cTnI), is...
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Open AccessUnraveling distinct effects between CuOx and PtCu alloy sites in Pt−Cu bimetallic catalysts for CO oxidation at different temperatures
In situ exploration of the dynamic structure evolution of catalysts plays a key role in revealing reaction mechanisms and designing efficient catalysts. In this work, PtCu/MgO catalysts, synthesized via the co...
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Open AccessWhole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals
Iron plays a fundamental role in multiple brain disorders. However, the genetic underpinnings of brain iron and its implications for these disorders are still lacking. Here, we conduct an exome-wide associatio...
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Open AccessProlonged ventricular repolarization associated with mild cognitive impairment and white matter hyperintensities: a cross-sectional study
Prolonged ventricular repolarization has been associated with cardiovascular disease. We sought to investigate the association of prolonged ventricular repolarization with mild cognitive impairment (MCI) and t...
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Open AccessGeographical migration and fitness dynamics of Streptococcus pneumoniae
Streptococcus pneumoniae is a leading cause of pneumonia and meningitis worldwide. Many different serotypes co-circulate endemically in any one location1,2. The extent and mechanisms of spread and vaccine-driven ...
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Open AccessAn increase of serum CA-125 to two times of nadir level strongly predicts the image-identified relapse of serous ovarian cancer
Using 70 U/ml or 35 U/ml as CA125 routine abnormal threshold may result in omissions in the relapse detection of Ovarian cancer (OvCa). This study aimed to clarify the association between a biochemical relapse...
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Open AccessClassification of brain tumor types through MRIs using parallel CNNs and firefly optimization
Image segmentation is a critical and challenging endeavor in the field of medicine. A magnetic resonance imaging (MRI) scan is a helpful method for locating any abnormal brain tissue these days. It is a diffic...
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Open AccessPresence and significance of telocytes in cholelithiasis and biliary dilatation in benign biliary disorders
Telocytes are closely associated with the regulation of tissue smooth muscle dynamics in digestive system disorders. They are widely distributed in the biliary system and exert their influence on biliary motil...
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Open AccessCross shard leader accountability protocol based on two phase atomic commit
Sharding blockchain is a technology designed to improve the performance and scalability of traditional blockchain systems. However, due to its design, communication between shards depends on shard leaders for ...
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Open AccessAuthor Correction: Synchronization analyze of k-uniform hyper-networks
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Open AccessNeutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein
Porcine deltacoronavirus (PDCoV) is an emerging enteric pathogen that has recently been detected in humans. Despite this zoonotic concern, the antigenic structure of PDCoV remains unknown. The virus relies on ...
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Open AccessLong-term balancing selection for pathogen resistance maintains trans-species polymorphisms in a planktonic crustacean
Balancing selection is an evolutionary process that maintains genetic polymorphisms at selected loci and strongly reduces the likelihood of allele fixation. When allelic polymorphisms that predate speciation e...
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Open AccessMulticenter and multimodal imaging study reveals rare fundus lesions in patients after SARS-CoV-2 infection
To define the characteristics of fundus manifestations in patients after SARS-CoV-2 infection with multimodal imaging techniques. This is a retrospective multicenter and multimodal imaging study including 90 p...
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Open AccessGlobal turnover of soil mineral-associated and particulate organic carbon
Soil organic carbon (SOC) persistence is predominantly governed by mineral protection, consequently, soil mineral-associated (MAOC) and particulate organic carbon (POC) turnovers have different impacts on the ...
