Skip to main content

3,066 Result(s)

within Human Genetics Remove this filter Ke** Zhang Remove this filter Medicine & Public Health Remove this filter

Page of 154
and

  1. No Access

    Article

    Csa-19, a radiation-responsive human gene, identified by an unbiased two-gel cDNA library screening method in human cancer cells

    A novel polymerase chain reaction (PCR)-based method was used to identify candidate genes whose expression is altered in cancer cells by ionizing radiation. Transcriptional induction of randomly selected genes...

    Elizabeth K Balcer-Kubiczek, Stephen J Meltzer, Lin-Huang Han, **ao-Feng Zhang… in Oncogene (1997)

  2. No Access

    Article

    PLC-γ activation is required for PDGF-βR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells

    To investigate the molecular mechanisms mediating hematopoietic cell differentiation and mitogenesis by activation of the platelet-derived growth factor β receptor (PDGF-βR), the wild type PDGF-βR (PDGF-βRWT) ...

    Maurizio Alimandi, Mohammad A Heidaran, J Silvio Gutkind, Jiachang Zhang… in Oncogene (1997)

  3. No Access

    Article

    The cDNA cloning of the transcripts of human PEBP2αA/CBFA1 mapped to 6p12.3-p21.1, the locus for cleidocranial dysplasia

    PEBP2/CBF is a heterodimeric transcription factor composed of α and β subunits. There are at least three closely related genes, PEBP2αA/Cbfa1, AML1/PEBP2αB/Cbfa2 and PEBP2αC/Cbfa3, encoding the α subunit and one ...

    Yu-Wen Zhang, Suk-Chul Bae, Ei-ichi Takahashi, Yoshiaki Ito in Oncogene (1997)

  4. No Access

    Article

    Partial characterization of the woodchuck tumor suppressor, p53, and its interaction with woodchuck hepatitis virus X antigen in hepatocarcinogenesis

    Full length cDNAs for p53 were made by reverse transcription-polymerase chain reaction of total RNA from two normal woodchuck livers. Two randomly chosen clones from each liver were sequenced and shown to be i...

    Mark A Feitelson, Perungavur N Ranganathan, Marcia M Clayton, Shu Min Zhang in Oncogene (1997)

  5. No Access

    Article

    New deletion in low-grade oligodendroglioma at the glioblastoma suppressor locus on chromosome 10q25-26

    Loss of heterozygosity on chromosome 10 is considered to be associated with the progression of glioblastomas. Two closely related regions have recently been proposed to contain the glioblastoma suppressor locu...

    Daniel Maier, Domenico Comparone, Elisabeth Taylor, Zuwen Zhang, Otmar Gratzl… in Oncogene (1997)

  6. No Access

    Article

    Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

    The farnesyltransferase (FTase) inhibitor FTI-277 is highly effective at blocking oncogenic H-Ras but not K-Ras4B processing and signaling. While inhibition of processing and signaling of oncogenic K-Ras4B is ...

    Edwina C Lerner, Ting-Ting Zhang, David B Knowles, Yimin Qian… in Oncogene (1997)

  7. No Access

    Article

    p53 expression overcomes p21WAF1/CIP1-mediated G1 arrest and induces apoptosis in human cancer cells

    The p21WAF1/CIP1 gene, which encodes a cyclin-dependent kinase inhibitor, may be critical for tumor suppressor gene p53-induced cell cycle arrest. The p53 gene is known to regulate G1 checkpoint, which can either...

    Shunsuke Kagawa, Toshiyoshi Fujiwara, Akio Hizuta, Tatsuji Yasuda… in Oncogene (1997)

  8. No Access

    Article

    MCF-7 breast carcinoma cells overexpressing FGF-1 form vascularized, metastatic tumors in ovariectomized or tamoxifen-treated nude mice

    FGF-1 is expressed in a high proportion of breast tumors. While overexpression of FGF-4 in the MCF-7 breast carcinoma cell line confers the ability to form spontaneously metastasizing tumors in ovariectomized ...

    Lurong Zhang, Samir Kharbanda, Denise Chen, Jamal Bullocks, David L Miller… in Oncogene (1997)

  9. No Access

    Article

    Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation

    ARK (AXL) is the prototype of a distinctive family of receptor tyrosine kinases which contain in their extracellular domains features reminiscent of cell adhesion molecules. ARK is capable of homophilic bindin...

    Paola Bellosta, Qing Zhang, Stephen P Goff, Claudio Basilico in Oncogene (1997)

  10. No Access

    Article

    Characterization of human N8 protein

    We have shown before that the N8 mRNA is expressed at higher levels in lung tumor and lung tumor-derived cell lines than normal lung cells. In this paper, we have characterized the N8 protein, and studied its ...

    Shin-Lin Chen, **an-Kui Zhang, Douglas O Halverson, Mee Kyeong Byeon… in Oncogene (1997)

  11. No Access

    Article

    PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a non estrogenic mechanism in the human endometrium

    Tamoxifen is currently the most widely used drug for the treatment of breast cancer, but there now exists considerable evidence that tamoxifen can also induce endometrial hyperplasia in pre menopausal women. W...

    Yuan Zhao, Stephen Hague, Sanjiv Manek, Lyna Zhang, Roy Bicknell… in Oncogene (1998)

  12. No Access

    Article

    Breast cancer genome anatomy: correlation of morphological changes in breast carcinomas with expression of the novel gene product Di12

    To determine which genes may be activated or inactivated during breast cancer development, we employed two cloning strategies (subtractive hybridization and differential display) using RNA samples from a human...

    Angelika Burger, Hua Li, **an-Kui Zhang, Malgorzata Pienkowska, Marco Venanzoni… in Oncogene (1998)

  13. No Access

    Article

    Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the develo** neural tube

    The ephrins are a family of ligands that bind to Eph family receptor tyrosine kinases, and have been implicated in axon guidance and other patterning processes during vertebrate development. We describe here t...

    Andrew D Bergemann, Lee Zhang, Ming-Ko Chiang, Riccardo Brambilla… in Oncogene (1998)

  14. No Access

    Article

    Amino acid and nucleotide sequences of human peroxisomal enoyl-CoA hydratase : 3-hydroxyacyl-CoA dehydrogenase cDNA

    Deficiency of enoyl-CoA hydratase : 3-hydroxyacyl-CoA dehydrogenase (peroxisomal bifunctional enzyme), one of the enzymes of the peroxisomal β-oxidation system, leads to clinical manifestations resembling Zell...

    S. Fukuda, Y. Suzuki, N. Shimozawa, Z. Zhang… in Journal of Inherited Metabolic Disease (1998)

  15. No Access

    Article

    Growth-dependent and PKC-mediated translational regulation of the upstream stimulating factor-2 (USF2) mRNA in hematopoietic cells

    Upstream stimulating factor (USF2) is a basic helix–loop–helix leucine zipper transcription factor, which is found in most tissues. A critical role for USF2 in cellular proliferation has been proposed based on...

    Zhao Cheng Zhang, Hovav Nechushtan, Jasmine Jacob-Hirsch, Dror Avni… in Oncogene (1998)

  16. No Access

    Article

    Production of interleukin-11 in bone-derived endothelial cells and its role in the formation of osteolytic bone metastasis

    The interactions of the cells in the bone microenvironment play important roles in bone remodeling. Osteoblasts are involved in the bone remodeling through the production of soluble factors that regulate proli...

    Yongke Zhang, Naoya Fujita, Tomoko Oh-hara, Yoshihiro Morinaga, Takumi Nakagawa… in Oncogene (1998)

  17. No Access

    Article

    Frequent homozygous deletions in the FRA3B region in tumor cell lines still leave the FHIT exons intact

    FRA3B at human chromosomal band 3p14.2 is the most active common fragile site in the human genome. The molecular mechanism of fragility at this region remains unknown but does not involve expansion of a trinuc...

    Liang Wang, John Darling, **-San Zhang, Chi-** Qian, Lynn Hartmann… in Oncogene (1998)

  18. No Access

    Article

    Overexpression of Bax gene sensitizes K562 erythroleukemia cells to apoptosis induced by selective chemotherapeutic agents

    Bax and Bcl-2 are a pair of important genes that control programmed cell death, or apoptosis, with Bax being the apoptosis promoter and Bcl-2 the apoptosis protector. Although the detailed mechanism is unknown, t...

    Tohru Kobayashi, Sanbao Ruan, Katharina Clodi, Kay-Oliver Kliche, Hiroshi Shiku… in Oncogene (1998)

  19. No Access

    Article

    The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells

    Mutations in p53 change the sensitivity to cancer chemotherapeutic drugs. Whereas many drugs, including the vinca alkaloids, often become less effective when p53 is transcriptionally inactivated, several, most...

    Christine C Zhang, **-Ming Yang, Eileen White, Maureen Murphy, Arnold Levine… in Oncogene (1998)

  20. No Access

    Article

    Inhibition of a naturally occurring EGFR oncoprotein by the p185neu ectodomain: implications for subdomain contributions to receptor assembly

    Mutant Epidermal Growth Factor Receptor (EGFR) oncoproteins lacking most of subdomains I and II of the extracellular region, a deletion which includes most of the first of two cysteine-rich sequences, have bee...

    Donald M O'Rourke, Eric JL Nute, James G Davis, Chuan** Wu, Acha Lee… in Oncogene (1998)

Page of 154