Skip to main content

23 Result(s)

within Joseph P. Balthasar Remove this filter

Page of 2 next disabled
and

  1. No Access

    Article

    Pharmacokinetic and pharmacodynamic effects of high-dose monoclonal antibody therapy in a rat model of immune thrombocytopenia

    Intravenous administration of pooled, polyvalent human immunoglobulin (IVIG) has been used for over 20 years as a therapy for immune thrombocytopenia (ITP). IVIG is available in limited quantities, and clinica...

    Feng **, Zia R. Tayab, Joseph P. Balthasar in The AAPS Journal (2005)

  2. No Access

    Article

    Pharmacodynamics of in Vivo Nitroglycerin Tolerance in Normal Conscious Rats: Effects of Dose and Dosing Protocol

    Purpose. We examined the effects of dose and dosing protocol on the pharmacodynamics of in vivo nitroglycerin (NTG) tolerance in conscious rats. Mechanism-based pharmcokinetic/pharmacodynamic (PK/PD) models were...

    Ellen Q. Wang, Joseph P. Balthasar, Ho-Leung Fung in Pharmaceutical Research (2004)

  3. No Access

    Article

    Application of Pharmacodynamic Modeling for Designing Time-Variant Dosing Regimens to Overcome Nitroglycerin Tolerance in Experimental Heart Failure

    Purpose. Prolonged continuous administration of nitroglycerin (NTG) leads to hemodynamic tolerance. We used a previously developed pharmacokinetic-pharmacodynamic (PK/PD) model of NTG tolerance in experimental h...

    John Anthony Bauer, Joseph P. Balthasar, Ho-Leung Fung in Pharmaceutical Research (1997)

Page of 2 next disabled