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  1. Article

    Open Access

    A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer

    Paclitaxel (PTX) is among the most commonly used first-line drugs for cancer chemotherapy. However, its poor water solubility and indiscriminate distribution in normal tissues remain clinical challenges. Here ...

    Fangfei Li, Jun Lu, ** Liu, Chao Liang, Maolin Wang, Luyao Wang in Nature Communications (2017)

  2. Article

    Open Access

    The effect of tetrahedron framed permeable weirs on river bed stability in a mountainous area under clear water conditions

    A flexible riverbed protection called tetrahedron framed permeable weirs (TFPW) is proposed to protect riverbeds in mountainous areas from scouring. Under clear water conditions, a series of laboratory flume e...

    Jia-mei Wang, **ng-guo Yang, Hong-wei Zhou, Zi-hao Wang, Jia-wen Zhou in Scientific Reports (2017)

  3. Article

    Open Access

    Ultrafast water sensing and thermal imaging by a metal-organic framework with switchable luminescence

    A convenient, fast and selective water analysis method is highly desirable in industrial and detection processes. Here a robust microporous Zn-MOF (metal–organic framework, Zn(hpi2cf)(DMF)(H2O)) is assembled from...

    Ling Chen, Jia-Wen Ye, Hai-** Wang, Mei Pan, Shao-Yun Yin in Nature Communications (2017)

  4. Article

    Open Access

    Hierarchical self-assembly of squaraine and silica nanoparticle functionalized with cationic coordination sites for near infrared detection of ATP

    Optical activity of hierarchical supramolecular assemblies based on organic dyes would create multiple functional architectures. In this work, three kinds of silica nanoparticles with or without functional gro...

    Ruizhi Feng, Weining Shi, Dejia Wang, Jia Wen, Hongjuan Li in Scientific Reports (2017)

  5. Article

    Open Access

    Construction of A Triple-Stimuli-Responsive System Based on Cerium Oxide Coated Mesoporous Silica Nanoparticles

    In this work, a triple-stimuli (GSH, pH and light irradiation) responsive system were designed based on CeO2 nanoparticles (CeO2 NPs) coated doxorubicin (DOX) and photosensitizer hematoporphyrin (HP) dual-loaded ...

    Jia Wen, Kui Yang, Yongqian Xu, Hongjuan Li, Fengyu Liu, Shiguo Sun in Scientific Reports (2016)

  6. Article

    Open Access

    Impaired receptivity and decidualization in DHEA-induced PCOS mice

    Polycystic ovary syndrome (PCOS), a complex endocrine disorder, is a leading cause of female infertility. An obvious reason for infertility in PCOS women is anovulation. However, success rate with high quality...

    Shu-Yun Li, Zhuo Song, Min-Jie Song, Jia-Wen Qin, Meng-Long Zhao in Scientific Reports (2016)

  7. Article

    Open Access

    An analysis of the entrainment effect of dry debris avalanches on loose bed materials

    Substrate entrainment can greatly influence the mass movement process of a debris avalanche because it can enlarge the landslide volume and change the motion characteristics of the sliding masses. To study th...

    Peng-yuan Lu, **ng-guo Yang, Fu-gang Xu, Tian-xing Hou, Jia-wen Zhou in SpringerPlus (2016)

  8. Article

    Open Access

    Forecasting and prevention of water inrush during the excavation process of a diversion tunnel at the **** II Hydropower Station, China

    Estimating groundwater inflow into a tunnel before and during the excavation process is an important task to ensure the safety and schedule during the underground construction process.

    Tian-xing Hou, **ng-guo Yang, Hui-ge **ng, Kang-xin Huang, Jia-wen Zhou in SpringerPlus (2016)

  9. Article

    Open Access

    High efficiency integration of three-dimensional functional microdevices inside a microfluidic chip by using femtosecond laser multifoci parallel microfabrication

    High efficiency fabrication and integration of three-dimension (3D) functional devices in Lab-on-a-chip systems are crucial for microfluidic applications. Here, a spatial light modulator (SLM)-based multifoci ...

    Bing Xu, Wen-Qiang Du, Jia-Wen Li, Yan-Lei Hu, Liang Yang in Scientific Reports (2016)

  10. Article

    Open Access

    Genetic dissection of heterosis using epistatic association map** in a partial NCII mating design

    Heterosis refers to the phenomenon in which an F1 hybrid exhibits enhanced growth or agronomic performance. However, previous theoretical studies on heterosis have been based on bi-parental segregating population...

    Jia Wen, **nwang Zhao, Guorong Wu, Dan **ang, Qing Liu, Su-Hong Bu in Scientific Reports (2015)

  11. Article

    Open Access

    Transforming berberine into its intestine-absorbable form by the gut microbiota

    The gut microbiota is important in the pathogenesis of energy-metabolism related diseases. We focused on the interaction between intestinal bacteria and orally administered chemical drugs. Oral administration ...

    Ru Feng, Jia-Wen Shou, Zhen-**ong Zhao, Chi-Yu He, Chao Ma, Min Huang in Scientific Reports (2015)

  12. Article

    Open Access

    Identification of domestication-related loci associated with flowering time and seed size in soybean with the RAD-seq genoty** method

    Flowering time and seed size are traits related to domestication. However, identification of domestication-related loci/genes of controlling the traits in soybean is rarely reported. In this study, we identifi...

    Ling Zhou, Shi-Bo Wang, Jianbo Jian, Qing-Chun Geng, Jia Wen in Scientific Reports (2015)

  13. No Access

    Article

    Enhancement and selective production of avermectin B by recombinants of Streptomyces avermitilis via intraspecific protoplast fusion

    Among eight components of avermectin, B1 fractions have the most effective antiparasitic activities and the lowest level of toxic side-effects and are used widely in veterinary and agricultural fields. Intrasp...

    Zhi Chen, Jia Wen, Yuan Song, Ying Wen, JiLun Li in Chinese Science Bulletin (2007)

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