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Article
Open AccessA water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer
Paclitaxel (PTX) is among the most commonly used first-line drugs for cancer chemotherapy. However, its poor water solubility and indiscriminate distribution in normal tissues remain clinical challenges. Here ...
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Article
Open AccessThe effect of tetrahedron framed permeable weirs on river bed stability in a mountainous area under clear water conditions
A flexible riverbed protection called tetrahedron framed permeable weirs (TFPW) is proposed to protect riverbeds in mountainous areas from scouring. Under clear water conditions, a series of laboratory flume e...
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Article
Open AccessUltrafast water sensing and thermal imaging by a metal-organic framework with switchable luminescence
A convenient, fast and selective water analysis method is highly desirable in industrial and detection processes. Here a robust microporous Zn-MOF (metal–organic framework, Zn(hpi2cf)(DMF)(H2O)) is assembled from...
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Article
Open AccessHierarchical self-assembly of squaraine and silica nanoparticle functionalized with cationic coordination sites for near infrared detection of ATP
Optical activity of hierarchical supramolecular assemblies based on organic dyes would create multiple functional architectures. In this work, three kinds of silica nanoparticles with or without functional gro...
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Article
Open AccessConstruction of A Triple-Stimuli-Responsive System Based on Cerium Oxide Coated Mesoporous Silica Nanoparticles
In this work, a triple-stimuli (GSH, pH and light irradiation) responsive system were designed based on CeO2 nanoparticles (CeO2 NPs) coated doxorubicin (DOX) and photosensitizer hematoporphyrin (HP) dual-loaded ...
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Article
Open AccessImpaired receptivity and decidualization in DHEA-induced PCOS mice
Polycystic ovary syndrome (PCOS), a complex endocrine disorder, is a leading cause of female infertility. An obvious reason for infertility in PCOS women is anovulation. However, success rate with high quality...
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Article
Open AccessAn analysis of the entrainment effect of dry debris avalanches on loose bed materials
Substrate entrainment can greatly influence the mass movement process of a debris avalanche because it can enlarge the landslide volume and change the motion characteristics of the sliding masses. To study th...
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Article
Open AccessForecasting and prevention of water inrush during the excavation process of a diversion tunnel at the **** II Hydropower Station, China
Estimating groundwater inflow into a tunnel before and during the excavation process is an important task to ensure the safety and schedule during the underground construction process.
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Article
Open AccessHigh efficiency integration of three-dimensional functional microdevices inside a microfluidic chip by using femtosecond laser multifoci parallel microfabrication
High efficiency fabrication and integration of three-dimension (3D) functional devices in Lab-on-a-chip systems are crucial for microfluidic applications. Here, a spatial light modulator (SLM)-based multifoci ...
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Article
Open AccessGenetic dissection of heterosis using epistatic association map** in a partial NCII mating design
Heterosis refers to the phenomenon in which an F1 hybrid exhibits enhanced growth or agronomic performance. However, previous theoretical studies on heterosis have been based on bi-parental segregating population...
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Article
Open AccessTransforming berberine into its intestine-absorbable form by the gut microbiota
The gut microbiota is important in the pathogenesis of energy-metabolism related diseases. We focused on the interaction between intestinal bacteria and orally administered chemical drugs. Oral administration ...
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Article
Open AccessIdentification of domestication-related loci associated with flowering time and seed size in soybean with the RAD-seq genoty** method
Flowering time and seed size are traits related to domestication. However, identification of domestication-related loci/genes of controlling the traits in soybean is rarely reported. In this study, we identifi...
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Article
Enhancement and selective production of avermectin B by recombinants of Streptomyces avermitilis via intraspecific protoplast fusion
Among eight components of avermectin, B1 fractions have the most effective antiparasitic activities and the lowest level of toxic side-effects and are used widely in veterinary and agricultural fields. Intrasp...