257 Result(s)
within
Jia-** Huang
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Open AccessDysfunctional TLR1 reduces the therapeutic efficacy of chemotherapy by attenuating HMGB1-mediated antitumor immunity in locally advanced colorectal cancer
Regional lymph node metastasis is an important predictor for survival outcome and an indicator for postoperative adjuvant chemotherapy in patients with colorectal cancer. Even with advances in adjuvant chemoth...
-
Article
Open AccessFollicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets
Follicle-stimulating hormone (FSH) is involved in mammalian reproduction via binding to FSH receptor (FSHR). However, several studies have found that FSH and FSHR play important roles in extragonadal tissue. H...
-
Article
Open AccessNeuro-inspired optical sensor array for high-accuracy static image recognition and dynamic trace extraction
Neuro-inspired vision systems hold great promise to address the growing demands of mass data processing for edge computing, a distributed framework that brings computation and data storage closer to the source...
-
Article
Open AccessSpatial atlas of the mouse central nervous system at molecular resolution
Spatially charting molecular cell types at single-cell resolution across the 3D volume is critical for illustrating the molecular basis of brain anatomy and functions. Single-cell RNA sequencing has profiled m...
-
Article
Open AccessClinical outcomes between elderly ESKD patients under peritoneal dialysis and hemodialysis: a national cohort study
With ageing populations, new elderly end-stage kidney disease (ESKD) cases rise. Unlike younger patients, elderly ESKD patients are less likely to undergo kidney transplant, and therefore the decision of recei...
-
Article
Open AccessInterlayer donor-acceptor pair excitons in MoSe2/WSe2 moiré heterobilayer
Localized interlayer excitons (LIXs) in two-dimensional moiré superlattices exhibit sharp and dense emission peaks, making them promising as highly tunable single-photon sources. However, the fundamental natur...
-
Article
Open AccessA linear and circular dual-conformation noncoding RNA involved in oxidative stress tolerance in Bacillus altitudinis
Circular RNAs have been extensively studied in eukaryotes, but their presence and/or biological functionality in bacteria are unclear. Here, we show that a regulatory noncoding RNA (DucS) exists in both linear...
-
Article
Open AccessAuthor Correction: A translational regulator MHZ9 modulates ethylene signaling in rice
-
Article
Open AccessSurgical resection versus transarterial chemoembolization for patients with hepatocellular carcinoma beyond Milan criteria: prognostic role of tumor burden score
Tumor burden score (TBS) has been recently introduced to indicate the extent of tumor burden in different cancers, but its role in advanced hepatocellular carcinoma (HCC) is unclear. We aimed to determine the ...
-
Article
Open AccessA longitudinal resource for population neuroscience of school-age children and adolescents in China
During the past decade, cognitive neuroscience has been calling for population diversity to address the challenge of validity and generalizability, ushering in a new era of population neuroscience. The develop...
-
Article
Open AccessGut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome
The incidence of metabolic syndrome is significantly higher in patients with irritable bowel syndrome (IBS), but the mechanisms involved remain unclear. Gut microbiota is causatively linked with the developmen...
-
Article
Open AccessA translational regulator MHZ9 modulates ethylene signaling in rice
Ethylene plays essential roles in rice growth, development and stress adaptation. Translational control of ethylene signaling remains unclear in rice. Here, through analysis of an ethylene-response mutant mhz9, w...
-
Article
Open AccessThe ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy
Sphingolipids are ubiquitous components of membranes and function as bioactive lipid signaling molecules. Here, through genetic screening and lipidomics analyses, we find that the endoplasmic reticulum (ER) ca...
-
Article
Open AccessA cryo-EM structure of KTF1-bound polymerase V transcription elongation complex
De novo DNA methylation in plants relies on transcription of RNA polymerase V (Pol V) along with KTF1, which produce long non-coding RNAs for recruitment and assembly of the DNA methylation machinery. Here, we...
-
Article
Open AccessEffect of a novel telehealth device for dietary cognitive behavioral intervention in overweight or obesity care
Obesity has become a major public health issue which relate to numerous physical problems and highly comorbid with depression and anxiety. Recently, some studies of technology-based interventions for weight re...
-
Article
Open AccessCausal structure of interacting Weyl fermions in condensed matter systems
The spacetime light cone is central to the definition of causality in the theory of relativity. Recently, links between relativistic and condensed matter physics have been uncovered, where relativistic particl...
-
Article
Open AccessDNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives chronic kidney disease progression in male mice
Kidney injury initiates epithelial dedifferentiation and myofibroblast activation during the progression of chronic kidney disease. Herein, we find that the expression of DNA-PKcs is significantly increased in...
-
Article
Open AccessVerifying the accuracy of self-reported smoking behavior in female volunteer soldiers
Smoking rates in the military are evaluated through questionnaire surveying. Because the accurate identification of smokers facilitates the provision of smoking cessation services, this study conducted urine c...
-
Article
Open AccessSingle-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis
Peritoneal metastasis is the leading cause of death for gastrointestinal cancers. The native and therapy-induced ascites ecosystems are not fully understood. Here, we characterize single-cell transcriptomes of...
-
Article
Open AccessActin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives
Deviations from mirror symmetry in the development of bilateral organisms are common but the mechanisms of initial symmetry breaking are insufficiently understood. The actin cytoskeleton of individual cells se...
