57 Result(s)
within
Javier Herrero
English
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Chapter and Conference Paper
The TV-AssistDem Project: A TV-Based Platform for Co** with Mild Cognitive Impairment
This paper describes work pursued within the TV-assistdem project, an AAL initiative, aim of which is develop a technological tool to remote support to patients affected by Mild Cognitive Impairment (MCI)...
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Article
Correction: Corrigendum: Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
Nature 545, 446–451 (2017); doi:10.1038/nature22364 For 6 of the 96 patients included in this Article (patients CRUK0014, CRUK0030, CRUK0048, CRUK0059, CRUK0096 and CRUK0097) incorrect tumour volumetric data a...
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Article
Statistically meaningful grain size analysis of CVD graphene based on the photocatalytic oxidation of copper
CVD graphene is a polycrystalline material, with grains typically smaller than a few microns. Although it is known that graphene’s grain size affects its properties, not much attention has been paid to develop...
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Article
Open AccessQuantification of tumour evolution and heterogeneity via Bayesian epiallele detection
Epigenetic heterogeneity within a tumour can play an important role in tumour evolution and the emergence of resistance to treatment. It is increasingly recognised that the study of DNA methylation (DNAm) patt...
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Article
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for l...
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Article
Open AccessCORALINA: a universal method for the generation of gRNA libraries for CRISPR-based screening
The bacterial CRISPR system is fast becoming the most popular genetic and epigenetic engineering tool due to its universal applicability and adaptability. The desire to deploy CRISPR-based methods in a large v...
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Saturation analysis for whole-genome bisulfite sequencing data
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Article
Open AccessdeconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution
Analysis of somatic mutations provides insight into the mutational processes that have shaped the cancer genome, but such analysis currently requires large cohorts. We develop deconstructSigs, which allows the...
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Article
Development of a molecular marker system to distinguish shell thickness in oil palm genotypes
The shell thickness gene Sh is one of the most important genes in oil palm. It controls the fruit type which in turn is associated with palm oil yield. Based on previous information about Sh alleles, we have deve...
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Article
Open AccessGenome-wide comparative analysis reveals human-mouse regulatory landscape and evolution
Because species-specific gene expression is driven by species-specific regulation, understanding the relationship between sequence and function of the regulatory regions in different species will help elucidat...
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Article
Extending reference assembly models
The human genome reference assembly is crucial for aligning and analyzing sequence data, and for genome annotation, among other roles. However, the models and analysis assumptions that underlie the current ass...
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Article
Open AccessA comparative encyclopedia of DNA elements in the mouse genome
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater in...
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Article
Open AccessGibbon genome and the fast karyotype evolution of small apes
Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal rearrangement and occupy a key node in the primate phylogeny between Old World monkeys and great apes. Here we prese...
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Article
Correction: Corrigendum: The draft genomes of soft-shell turtle and green sea turtle yield insights into the development and evolution of the turtle-specific body plan
Nat. Genet. 45, 701–706 (2013); published online 28 April 2013; corrected after print 28 May 2014 In the version of this article initially published, the claim that the ghrelin gene was lost specifically in th...
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Correction: Corrigendum: The zebrafish reference genome sequence and its relationship to the human genome
Nature 496, 498–503 (2013); doi:10.1038/nature12111 In this Letter, five authors were inadvertently omitted: Sharmin Begum and Christine Lloyd from the Wellcome Trust Sanger Institute, and Christa Lanz, Günter...
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Article
Open AccessStem cells isolated from adipose tissue of obese patients show changes in their transcriptomic profile that indicate loss in stemcellness and increased commitment to an adipocyte-like phenotype
The adipose tissue is an endocrine regulator and a risk factor for atherosclerosis and cardiovascular disease when by excessive accumulation induces obesity. Although the adipose tissue is also a reservoir for...
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Article
Open AccessThe duck genome and transcriptome provide insight into an avian influenza virus reservoir species
Ning Li and colleagues report the whole-genome sequence of the duck, Anas platyrhynchos, a natural host of avian influenza viruses. They examine host response to infection by comparing the lung transcriptomes of ...
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Article
Open AccessThe draft genomes of soft-shell turtle and green sea turtle yield insights into the development and evolution of the turtle-specific body plan
Naoki Irie and colleagues report the draft genomes of the soft-shell and green sea turtles. Their genome-wide phylogenetic analysis supports the hypothesis that turtles are a sister group of crocodilians and b...
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Article
Open AccessThe zebrafish reference genome sequence and its relationship to the human genome
A high-quality sequence assembly of the zebrafish genome reveals the largest gene set of any vertebrate and provides information on key genomic features, and comparison to the human reference genome shows that...
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Article
Open AccessSequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution
Jeramiah Smith, Weiming Li and colleagues report the whole-genome sequence of the sea lamprey, Petromyzon marinus, representing a vertebrate lineage diverged from humans ~500 million years ago. Their analyses def...
