-
Article
Open AccessBDNF promoter methylation and genetic variation in late-life depression
The regulation of the brain-derived neurotrophic factor (BDNF) is important for depression pathophysiology and epigenetic regulation of the BDNF gene may be involved. This study investigated whether BDNF methylat...
-
Article
Distances of Centroid Sets in a Graph-Based Construction for Information Security Applications
The aim of this paper is to prove that, for every balanced digraph, in every incidence semiring over a semifield, each centroid set J of the largest distance also has the largest weight, and the distance of J is ...
-
Article
Open AccessC-reactive protein gene variants: independent association with late-life depression and circulating protein levels
C-reactive protein (CRP) is a heritable biomarker of systemic inflammation that is commonly elevated in depressed patients. Variants in the CRP gene that influence protein levels could thus be associated with dep...
-
Article
Erratum: Bcl-xL controls a switch between cell death modes during mitotic arrest
Correction to: Cell Death and Disease (2014) 5, e1291; doi:10.1038/cddis.2014.251; published online 12 June 2014 Since the publication of this article the authors have noticed an error in Figure 7c. pS62DBcl-x...
-
Article
Open AccessBcl-xL controls a switch between cell death modes during mitotic arrest
Antimitotic agents such as microtubule inhibitors (paclitaxel) are widely used in cancer therapy while new agents blocking mitosis onset are currently in development. All these agents impose a prolonged mitoti...
-
Article
A guide to assessing physical activity using accelerometry in cancer patients
Increased physical activity (PA) has been associated with a decreased risk for the occurrence and recurrence of many cancers. PA is an important outcome measure in rehabilitation interventions within cancer an...
-
Article
Open AccessAngiotensin-converting enzyme gene variants are associated with both cortisol secretion and late-life depression
Angiotensin-converting enzyme (ACE) is assumed to influence the activity of the hypothalamic–pituitary–adrenocortical (HPA) axis, which shows hyperactivity in depressed patients. ACE could thus be a promising can...
-
Article
Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs
MicroRNAs (miRNAs) contribute to the pathogenesis of many forms of cancer, including the pediatric cancer neuroblastoma, but the underlying mechanisms leading to altered miRNA expression are often unknown. Her...
-
Article
Open AccessErratum: MicroRNA-204 increases sensitivity of neuroblastoma cells to cisplatin and is associated with a favourable clinical outcome
Correction to: British Journal of Cancer (2012) 107, 967–976. doi:10.1038/bjc.2012.356 Upon publication online and in print, the authors realised that a contributor to the original data for this manuscript had...
-
Article
Open AccessMicroRNA-204 increases sensitivity of neuroblastoma cells to cisplatin and is associated with a favourable clinical outcome
Neuroblastoma remains a major cause of cancer-linked mortality in children. miR-204 has been used in microRNA expression signatures predictive of neuroblastoma patient survival. The aim of this study was to ex...
-
Article
A Novel Fatty Acid, 12,17-Dimethyloctadecanoic Acid, from the Extremophile Thermogemmatispora sp. (Strain T81)
The major fatty acids of a novel species of Thermogemmatispora sp. (strain T81) from the phylum Chloroflexi were identified as i18:0 (42.8 % of total fatty acids), i19:0 (9.7 %), and i17:0 (5.9 %). Also observed ...
-
Article
Fatty Acids of Chthonomonas calidirosea, of a Novel Class Chthonomonadetes from a Recently Described Phylum Armatimonadetes
A Gram-negative, aerobic, pink-pigmented, rod-shaped bacterium Chthonomonas calidirosea (strain T49T) with an optimal temperature for growth of 68 °C, isolated from soil samples from Hell’s Gate in the Tikitere g...
-
Article
Clique Vertex Magic Cover of a Graph
Let G admit an H-edge covering and \({f : V \cup E \to \{1,2,\ldots,n+e\}}\) be a bijective map** for G then f is c...
-
Chapter and Conference Paper
A New Discontinuous Galerkin Method for the Navier–Stokes Equations
We introduce a new discontinuous Galerkin (EDG) method to solve the compressible Navier–Stokes equations where jumps across element boundaries are eliminated in the computation of the viscous fluxes using an L ...
-
Article
Asymptomatic carriage of Clostridium difficile in an Irish continuing care institution for the elderly: prevalence and characteristics
Clostridium difficile is an increasing cause of nosocomial diarrhoea and colitis. The aim of this study was to identify the prevalence and characteristics of asymptomatic C. difficile carriage in a continuing car...
-
Article
Loss of nitrogen from urea applied to rainfed wheat in varying rainfall zones in northern Syria
Fertilizer-applied Nitrogen (N) may be lost from the soil by various mechanisms, i.e., runoff, leaching, denitrification, and volatilization. The latter process is of primary concern in calcareous soils of ari...
-
Chapter and Conference Paper
Towards Direct Numerical Simulation of a Diffusion Flame-Shock Interaction with an AMR Algorithm
A reactive solver based on a time splitting method has been coupled with an AMR platform. After having tested the solver potentiality, a diffusion flame/shock interaction is presented with AMR.
-
Article
BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals
Here we investigate the function of zebrafish Bcl-2 family proteins and demonstrate important conservation of function across zebrafish and mammalian systems. We have isolated a zebrafish ortholog of mammalian BI...
-
Article
Development of a process modelling tool for simulation
An important phase in any simulation project is the pre-coding phase. This phase involves such tasks as problem definition, project planning, system definition, conceptual model formulation, preliminary experi...
-
Article
The influence of cyclosporin alone, or cyclosporin and methotrexate, on the incidence of mixed haematopoietic chimaerism following allogeneic sibling bone marrow transplantation for severe aplastic anaemia
We previously reported a randomized trial comparing Cyclosporin-A (CsA) and short-term methotrexate versus CsA alone for graft-versus-host disease (GvHD) prophylaxis in 71 patients undergoing allogeneic haemat...
