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  1. Article

    Open Access

    Toward the next generation EGFR inhibitors: an overview of osimertinib resistance mediated by EGFR mutations in non-small cell lung cancer

    Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) is currently the standard first-line therapy for EGFR-mutated advanced non-small cell lung cancer (NSCLC). The life quality and survival of th...

    Yufeng Li, Tianyu Mao, **g Wang, Hongrui Zheng in Cell Communication and Signaling (2023)

  2. No Access

    Article

    Attention-based deep learning for breast lesions classification on contrast enhanced spectral mammography: a multicentre study

    This study aims to develop an attention-based deep learning model for distinguishing benign from malignant breast lesions on CESM.

    Ning Mao, Haicheng Zhang, Yi Dai, Qin Li, Fan Lin, **g Gao in British Journal of Cancer (2023)

  3. Article

    Open Access

    Mean platelet volume/platelet count ratio in combination with tumor markers in colorectal cancer: a retrospective clinical study

    Mean platelet volume (MPV) is a marker of platelet activation, which is usually negatively correlated with platelet count (PC). The ratio of MPV to PC (MPV/PC) has an essential role in the diagnosis of multipl...

    Huan Zhang, Fan Lin, Zhuocai Wang in BMC Cancer (2023)

  4. No Access

    Article

    Real-time fluorescent cholangiography with indocyanine green in laparoscopic cholecystectomy: a randomized controlled trial to establish the optimal indocyanine green dose within 30 min preoperatively

    To establish the optimal dose of indocyanine green (ICG) to administer intravenously 30 min before laparoscopic cholecystectomy (LC).

    Yu Huang, Qiangxing Chen, Jiao Kuang, Shuai Zhang, Jiefeng Weng in Surgery Today (2023)

  5. No Access

    Article

    Fludarabine- and low-dose cyclophosphamide-based conditioning regimens provided favorable survival and engraftment for unmanipulated hematopoietic cell transplantation from unrelated donors and matched siblings in patients with Fanconi anemia: results from the CBMTR

    Lan** Xu, Yue Lu, **g Chen, Shuwen Sun, Shaoyan Hu in Bone Marrow Transplantation (2023)

  6. No Access

    Chapter and Conference Paper

    A Correlational Strategy for the Prediction of High-Dimensional Stock Data by Neural Networks and Technical Indicators

    Stock price prediction generates interesting outputs for investors. In recent years, stock technical indicators (STI) have played an important role in stock price prediction. However, the current performance o...

    **gwei Hong, ** Han, Abdur Rasool, Hui Chen, Zhiling Hong in Big Data and Security (2023)

  7. Article

    Open Access

    GCNCPR-ACPs: a novel graph convolution network method for ACPs prediction

    Anticancer peptide (ACP) inhibits and kills tumor cells. Research on ACP is of great significance for the development of new drugs, and the prediction of ACPs and non-ACPs is the new hotspot.

    **u** Wu, Wenhua Zeng, Fan Lin in BMC Bioinformatics (2022)

  8. No Access

    Article

    Intermedin1–53 Inhibits NLRP3 Inflammasome Activation by Targeting IRE1α in Cardiac Fibrosis

    Intermedin (IMD), a paracrine/autocrine peptide, protects against cardiac fibrosis. However, the underlying mechanism remains poorly understood. Previous study reports that activation of nucleotide-binding oli...

    Lin-Shuang Zhang, **-Sheng Zhang, Yue-Long Hou, Wei-Wei Lu, **an-Qiang Ni in Inflammation (2022)

  9. Article

    Open Access

    Genetic evidence supports the development of SLC26A9 targeting therapies for the treatment of lung disease

    Over 400 variants in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) are CF-causing. CFTR modulators target variants to improve lung function, but marked variability in response exists and cur...

    Jiafen Gong, Gengming He, Cheng Wang, Claire Bartlett in npj Genomic Medicine (2022)

  10. No Access

    Chapter

    Unknown Primary/Undifferentiated Neoplasms

    This chapter provides a practical overview of frequently used markers in the diagnosis and differential diagnosis of both common and rare metastatic tumors and undifferentiated neoplasms with a specific focus ...

    Fan Lin, Haiyan Liu in Handbook of Practical Immunohistochemistry (2022)

  11. No Access

    Chapter and Conference Paper

    Temporal Convolution Network Based on Attention for Intelligent Anomaly Detection of Wind Turbine Blades

    With the concept of “carbon neutral”, wind power industry ushers in a golden period of development. Wind turbine blades are the key components of wind turbine, their normal operation directly affects the opera...

    Jianwen Ding, Fan Lin, Shengbo Lv in Algorithms and Architectures for Parallel Processing (2022)

  12. No Access

    Chapter

    Prostate Gland

    This chapter provides a practical overview of frequently used markers in the diagnosis and differential diagnosis of both common and rare neoplasms of prostate gland, with a specific focus on adenocarcinoma an...

    Haiyan Liu, Fan Lin, Qihui “Jim” Zhai in Handbook of Practical Immunohistochemistry (2022)

  13. No Access

    Chapter

    Kidney

    This chapter provides a practical overview of frequently used markers in the diagnosis and differential diagnosis of both common and rare renal neoplasms, with a specific focus on renal epithelial tumors and t...

    Fan Lin, **ming J. Yang in Handbook of Practical Immunohistochemistry (2022)

  14. No Access

    Chapter

    Pancreas and Ampulla

    This chapter provides a practical overview of frequently used markers in the diagnosis and differential diagnosis of both common and rare pancreatic and ampullary neoplasms, with a specific focus on pancreatic...

    Fan Lin, Hanlin L. Wang in Handbook of Practical Immunohistochemistry (2022)

  15. No Access

    Chapter

    Upper Gastrointestinal Tract

    The application of immunohistochemistry (IHC) in diagnostic gastrointestinal (GI) pathology is similar to that in many other organ systems. The most commonly used markers are epithelial cell markers, such as c...

    **hong Li, Fan Lin in Handbook of Practical Immunohistochemistry (2022)

  16. No Access

    Chapter

    RNA In Situ Hybridization: Applications in Anatomic Pathology

    This chapter focuses on RNA in situ hybridization (RNA ISH) technology and applications of RNA ISH in anatomic pathology. Over the last several years, novel RNA ISH methods that utilize signal amplification, s...

    Fan Lin, Jeffrey Kim, Robert Monroe in Handbook of Practical Immunohistochemistry (2022)

  17. No Access

    Chapter

    Thyroid, Parathyroid, and Adrenal Glands

    This chapter provides a practical overview of frequently used markers in the diagnosis and differential diagnosis of both common and rare neoplasms of the thyroid, parathyroid and adrenal glands, with a specif...

    Haiyan Liu, Myra L. Wilkerson, Fan Lin in Handbook of Practical Immunohistochemistry (2022)

  18. No Access

    Chapter

    Liver, Bile Ducts, and Gallbladder

    Immunohistochemistry (IHC) is an indispensable tool for pathological diagnosis of both neoplastic and non-neoplastic diseases of the liver and biliary tract. It has a wide spectrum of application ranging from ...

    Jianhong Li, Zongming Eric Chen, Fan Lin in Handbook of Practical Immunohistochemistry (2022)

  19. No Access

    Chapter

    Standardization of Diagnostic Immunohistochemistry

    Standardization of every step in the pre-analytic, analytic, and post-analytic phases is crucial to achieving reproducible and reliable immunohistochemistry results. This chapter delineates some critical point...

    Fan Lin, Jianhui Shi in Handbook of Practical Immunohistochemistry (2022)

  20. No Access

    Chapter

    Lower Gastrointestinal Tract and Microsatellite Instability (MSI)

    By conventional definition, the lower gastrointestinal (GI) tract includes the appendix, entire colon, and anus. Diseases involving these organs are traditionally classified into nonneoplastic and neoplastic c...

    Guoli Chen, Jianhong Li, Zongming Eric Chen in Handbook of Practical Immunohistochemistry (2022)

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