![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
101 Result(s)
-
Article
PIK3R2 predicts poor outcomes for patients with melanoma and contributes to the malignant progression via PI3K/AKT/NF-κB axis
Melanoma is an aggressive form of skin cancer worldwide. Phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2) exerts carcinogenic roles in various tumors. So far, the function and mechanism of PIK3R2 in me...
-
Article
Open AccessEosinophilic solid and cystic renal cell carcinoma with TSC2 mutation: a case report and literature review
Eosinophilic solid and cystic renal cell carcinoma (ESC-RCC) is an under-recognized, emerging new entity of sporadic renal neoplasms, which is listed as a rare type of renal cell carcinoma in the 2022 WHO rena...
-
Article
Open AccessAcinar cell carcinoma of gastric ectopic pancreas origin: a case report and literature review
Primary pancreatic-type acinar cell carcinoma of the stomach is extremely rare, often misdiagnosed, and of unclear origin.
-
Article
Open AccessNeuroendocrine differentiation: a risk fellow in colorectal cancer
Neuroendocrine differentiation (NED) is often found in colorectal cancer (CRC) and may have unique biological behavior, which has not been previously delineated. Here, we explore the relationship between CRC, ...
-
Article
Open AccessDlk1 maintains adult mice long-term HSCs by activating Notch signaling to restrict mitochondrial metabolism
Adult hematopoietic stem cells (HSCs) homeostasis is critically important in maintaining lifelong hematopoiesis. However, how adult HSCs orchestrate its homeostasis remains not fully understood. Imprinted gene...
-
Article
Open AccessSinonasal mucosal melanoma with smooth muscle differentiation: a potential pathological diagnostic pitfall
Sinonasal mucosal melanoma (SNMM) is a rare malignant melanoma originating from melanocytes derived from multipotent neural crest cells. Its incidence accounts for less than 1 % of all malignant melanomas, wit...
-
Article
Open AccessPrognostic value of elastic lamina staining in patients with stage III colon cancer
The objectives of this study were to analyze the difference between the preoperative radiological and postoperative pathological stages of colorectal cancer (CRC) and explore the feasibility of elastic lamina ...
-
Article
Open AccessComparison of the duration of viral RNA shedding and anti-SARS-CoV-2 spike IgG and IgM antibody titers in COVID-19 patients who were vaccinated with inactivated vaccines or not: a retrospective study
At present, the role of inactivated vaccines in viral RNA shedding among Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) breakthrough infections is still unknown.
-
Article
A retrospective analysis of transanal surgical management of 291 cases with rectal foreign bodies
Rectal foreign bodies (RFB) are quite uncommon except in very busy hospitals. Because of their rarity, it is seldom that the treating physicians have a standard approach to the diagnosis, technique of extracti...
-
Article
Open AccessChimeric antigen receptor T-cell therapy for relapsed and refractory thyroid cancer
The prognosis of most thyroid cancer patients is excellent, but for those with advanced or metastatic thyroid cancer, effective treatments are still lacking. Chimeric antigen receptor (CAR) T-cell therapy has ...
-
Article
Open AccessAn updated RBD-Fc fusion vaccine booster increases neutralization of SARS-CoV-2 Omicron variants
-
Article
Open AccessPredominantly epithelial-type synovial sarcoma with overwhelming neuroendocrine differentiation: a potential diagnostic pitfall
Synovial sarcoma is an uncommon soft tissue tumor of soft tissue, characterized by a specific SS18 rearrangement. It generally manifests as a lesion composed of monomorphic spindle cells and sometimes shows va...
-
Article
Open AccessAcetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor development
Acetyl-CoA synthetase 2 (ACSS2), an important member of the acetyl-CoA synthetase (ACSS) family, can catalyze the conversion of acetate to acetyl coenzyme A (acetyl-CoA). Currently, acetyl-CoA is considered an...
-
Article
Can echocardiographic assessment of diastolic function be automated?
Echocardiographic evaluation of left ventricular diastolic function relies on a multi-pronged algorithm, which incorporates Doppler-based and volumetric parameters. Integration of clinical data in diastolic as...
-
Article
Open AccessAptamer blocking S-TLR4 interaction selectively inhibits SARS-CoV-2 induced inflammation
-
Article
Open AccessLaparoscopic versus open reduction of idiopathic intussusception in children: an updated institutional experience
In the reduction of intussusception, due to the lack of randomized, controlled, and prospective clinical trials to confirm the superiority of the laparoscopic approach over open surgery, more evidence was need...
-
Article
Open AccessSuccess of small-dose fractionated sodium thiosulfate in the treatment of calciphylaxis in a peritoneal dialysis patient
Calciphylaxis, or calcific uremic arteriolopathy (CUA), is a rare, fatal disorder of microvascular calcification and thrombosis that typically affects patients with end-stage renal disease (ESRD) receiving lon...
-
Article
Open AccessCharacterization of gut microbiome in mice model of depression with divergent response to escitalopram treatment
Depression is a common and heterogeneous mental disorder. Although several antidepressants are available to treat the patients with depression, the factors which could affect and predict the treatment response...
-
Article
Open AccessmiR-122-5p regulates the tight junction of the blood-testis barrier of mice via occludin
Occludin protein is the primary assembling protein of TJs and the structural basis for tight junction formation between Sertoli cells in the spermatogenic epithelium. The expression of miR-122-5p and occludin ...
-
Article
Metabolism and immunity in breast cancer
Breast cancer is one of the most common malignancies that seriously threaten women’s health. In the process of the malignant transformation of breast cancer, metabolic reprogramming and immune evasion represen...