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Article
Open AccessSafety and efficacy of PG102P for the control of pruritus in patients undergoing hemodialysis (SNUG trial): study protocol for a randomized controlled trial
Pruritus in patients undergoing hemodialysis is a highly prevalent complication that affects quality of life. Several medications are currently used for the treatment of uremic pruritus, but these are not sati...
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Article
Open AccessRenoprotective effects of a novel cMet agonistic antibody on kidney fibrosis
Hepatocyte growth factor (HGF) and its receptor, cMet, activate biological pathways necessary for repair and regeneration following kidney injury. Because HGF is a highly unstable molecule in its biologically ...
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Article
Open AccessThe impact of sunlight exposure on mortality of patients with end stage renal disease
Recent data suggest that reduced sunlight exposure is associated with increased mortality in the general population. To date, the association between sunlight exposure and mortality in dialysis patients has no...
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Article
Open AccessThe association of tumor necrosis factor superfamily 13 with recurrence of immunoglobulin A nephropathy in living related kidney transplantation
An increasing amount of evidence has demonstrated an association between an increase in the level of tumor necrosis factor superfamily 13 (TNFSF13) and immunoglobulin A nephropathy (IgAN) progression. We aimed...
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Article
Open AccessSoluble cMet levels in urine are a significant prognostic biomarker for diabetic nephropathy
Hepatocyte growth factor and its receptor cMet activate biological pathways necessary for repair and regeneration following kidney injury. Here, we evaluated the clinical role of urinary cMet as a prognostic b...
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Article
Open AccessA Machine Learning Approach Using Survival Statistics to Predict Graft Survival in Kidney Transplant Recipients: A Multicenter Cohort Study
Accurate prediction of graft survival after kidney transplant is limited by the complexity and heterogeneity of risk factors influencing allograft survival. In this study, we applied machine learning methods, ...
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Article
Open AccessFactors affecting the long-term outcomes of idiopathic membranous nephropathy
We attempted to describe the clinical features and determine the factors associated with renal survival in idiopathic membranous nephropathy (iMN) patients with nephrotic syndrome (NS) and to determine the fac...
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Article
Open AccessEarly initiation of continuous renal replacement therapy improves survival of elderly patients with acute kidney injury: a multicenter prospective cohort study
Continuous renal replacement therapy (CRRT) is essential in the management of critically ill patients with acute kidney injury (AKI). However, the optimal timing for initiating CRRT remains controversial, espe...
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Article
Open AccessUrinary adiponectin and albuminuria in non-diabetic hypertensive patients: an analysis of the ESPECIAL trial
Although adiponectin levels have been reported to be correlated with albuminuria, this issue remains unresolved in non-diabetic hypertensive subjects, particularly when urinary adiponectin is considered.
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Article
Open AccessPretransplant malnutrition, inflammation, and atherosclerosis affect cardiovascular outcomes after kidney transplantation
Malnutrition, inflammation, and atherosclerosis (MIA) syndrome is associated with a high mortality rate in patients with end-stage renal disease. However, the clinical relevance of MIA syndrome in kidney trans...
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Article
Open AccessNon-linear association of serum 25-hydroxyvitamin D with urinary albumin excretion rate in normoalbuminuric subjects
Vitamin D deficiencies and increases in urinary albumin excretion (UAE) are both important and potentially related health problems; however, the nature of their relationship has not been established in normoal...
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Article
Open AccessLong-term prognosis of clinically early IgA nephropathy is not always favorable
The long-term prognosis of clinically early IgA nephropathy (IgAN) patients remains to be clarified. We investigated the long-term outcomes of IgAN patients with an apparently benign presentation and evaluated...
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Article
Open AccessDose selection method for pharmacokinetic study in hemodialysis patients using a subpharmacological dose: oseltamivir as a model drug
Dose selection is an important step in pharmacokinetic (PK) studies of hemodialysis patients. We propose a simulation-based dose-selection method for PK studies of hemodialysis patients using a subpharmacologi...
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Article
Open AccessEffect of beraprost sodium on arterial stiffness in patients with type 2 diabetic nephropathy
Diabetic nephropathy is the leading cause of end-stage renal disease (ESRD). Cardiovascular (CV) complications are the most common cause of death among ESRD patients. Beraprost sodium (BPS) is a prostacyclin a...
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Article
Open AccessSevere hyperkalemia requiring hospitalization: predictors of mortality
Severe hyperkalemia, with potassium (K+) levels ≥ 6.5 mEq/L, is a potentially life-threatening electrolyte imbalance. For prompt and effective treatment, it is important to know its risk factors, clinical manifes...
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Article
Open AccessThe association of moderate renal dysfunction with impaired preference-based health-related quality of life: 3rdKorean national health and nutritional examination survey
Only a few large-scale studies have investigated the association between health-related quality of life (HRQOL) and renal function. Moreover, the HRQOL of patients with moderate renal dysfunction is frequently...
