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Article
Selinexor demonstrates anti-tumor efficacy in paired patient-derived xenograft models and hydrogel-embedded histoculture drug sensitivity test of penile cancer
Penile cancer is a rare malignancy with a poor prognosis, even with various treatment options. Considering the little progress in the study of the pathogenesis and treatment of penile cancer because of the lac...
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Article
Correcting the Broad, Flat and Short Chin Using Modified M-genioplasty
Several genioplasty techniques can narrow the width of the chin. Nevertheless, patients with a broad and short chin who received these methods were unsatisfied with the outcomes. The goal of this study was to ...
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Article
FLOT1 knockdown inhibits growth of AML cells through triggering apoptosis and pyroptosis
Acute myeloid leukemia (AML) is a group of hematological malignancies characterized by clonal proliferation of immature myeloid cells. Lipid rafts are highly organized membrane subdomains enriched in cholester...
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Article
Open AccessSpermatogenesis associated serine rich 2 like plays a prognostic factor and therapeutic target in acute myeloid leukemia by regulating the JAK2/STAT3/STAT5 axis
Spermatogenesis associated serine rich 2 like (SPATS2L) was highly expressed in homoharringtonine (HHT) resistant acute myeloid leukemia (AML) cell lines. However, its role is little known in AML. The present ...
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Article
Correction: A comprehensive review of digital twin—part 2: roles of uncertainty quantification and optimization, a battery digital twin, and perspectives
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Article
Open AccessComparison of cortical versus cancellous bone fixation in tendon-to-bone healing with a rat trans-calcaneal suture model for Achilles tendon sleeve avulsion
Trans-calcaneal suture technique is an economical and effective method for repairing Achilles tendon sleeve avulsion. Whether cancellous bone fixation upon this technique could accelerate tendon-to-bone healin...
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Chapter and Conference Paper
High-Rate Structural Health Monitoring: Part-III Algorithms
The real-time estimation of the structural health of high-rate systems, termed “high-rate structural health monitoring” (HRSHM), is critical in designing decision mechanisms that can ensure structural integrit...
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Article
A comprehensive review of digital twin—part 2: roles of uncertainty quantification and optimization, a battery digital twin, and perspectives
As an emerging technology in the era of Industry 4.0, digital twin is gaining unprecedented attention because of its promise to further optimize process design, quality control, health monitoring, decision- an...
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Article
A comprehensive review of digital twin — part 1: modeling and twinning enabling technologies
As an emerging technology in the era of Industry 4.0, digital twin is gaining unprecedented attention because of its promise to further optimize process design, quality control, health monitoring, decision and...
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Article
Health index construction with feature fusion optimization for predictive maintenance of physical systems
In any prognostics and health management framework, the key to accurate remaining useful life prediction is finding a signal that directly quantifies the health status of a physical asset. When a direct measur...
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Article
Surrogate modeling of acoustic field-assisted particle patterning process with physics-informed encoder–decoder approach
Manipulating the distribution of functional particles in a polymer matrix can enable the fabrication of multifunctional smart composite devices. Using an acoustic field for particle patterning is a promising t...
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Article
An efficient direct evaluation of reliability for slopes using low-discrepancy sampling
In this paper, to improve the computational efficiency of the reliability methods in evaluating the stability of slopes based on the uncertainty of soil properties, an efficient direct simulation approach usin...
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Article
Open AccessCone-beam computed tomography is not a mandatory procedure in adrenal venous sampling for primary hyperaldosteronism
To investigate the necessity of cone-beam computed tomography (CBCT) in adrenal venous sampling (AVS).
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Article
Enhanced M-CSF/CSF1R Signaling Closely Associates with PrPSc Accumulation in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents
Activation and proliferation of microglia are one of the hallmarks of prion disease and is usually accompanied by increased levels of various cytokines and chemokines. Our previous study demonstrated that the ...
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Article
Open AccessA physicochemical double-cross-linked gelatin hydrogel with enhanced antibacterial and anti-inflammatory capabilities for improving wound healing
Skin tissue is vital in protecting the body from injuries and bacterial infections. Wound infection caused by bacterial colonization is one of the main factors hindering wound healing. Wound infection caused b...
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Article
Open AccessSNHG25 facilitates SNORA50C accumulation to stabilize HDAC1 in neuroblastoma cells
Increasing studies have pointed out that small nucleolar RNAs (snoRNAs) and their host genes (SNHGs) have multi-functional roles in cancer progression. Bioinformatics analysis revealed the importance of snoRNA...
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Article
Pharmacokinetics and Safety of Erenumab after a Single Subcutaneous Injection Dose in Healthy Chinese Subjects
Erenumab is the first-in-class, selective, and competitive human monoclonal antibody antagonist of the calcitonin gene-related peptide (CGRP) receptor that has been shown to be effective and well-tolerated in ...
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Article
A non-aqueous phase extraction system using tributyl phosphate for H3PO4 separation from wet-process superphosphoric acid: Extraction equilibrium and mechanism
Conventional wet-process phosphoric acid (WPA) extraction route encounters unsatisfactory extraction efficiency, phosphorus yield, and raffinate utilization. Herein, a new extraction route for H3PO4 separation fr...
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Article
GAS41 mediates proliferation and GEM chemoresistance via H2A.Z.2 and Notch1 in pancreatic cancer
GAS41 is a YEATS domain protein that binds to acetylated histone H3 to promote the chromatin deposition of H2A.Z in non-small cell lung cancer. The role of GAS41 in pancreatic cancer is still unknown. Here, we...
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Article
Slope reliability evaluation using an improved Kriging active learning method with various active learning functions
To enhance the efficiency of slope reliability analysis, this paper presents an improved active learning Kriging method integrated with the Monte Carlo simulation. The turbulent flow of water-based optimizatio...
