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Chapter
Macrophages as an Important Source of Paracrine IL6 in Myeloma Bone Marrow
Interleukin 6 (IL6) is a pleiotropic cytokine which has been shown to be a very potent growth factor for myeloma cells, particularly cells derived from patients with aggressive clinical disease (1,2). Although it...
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Article
DANAZOL-INDUCED FACTOR IX AND VIII BYPASSING ACTIVITY
Danazol, a synthetic androgen reported to increase factor VIII and IX activity levels, was given to 5 hemophiliacs who were >17 years old (3 with severe hemophilia A, one moderate hemophilia A and one moderate...
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Article
EFFECT OF DANAZOL ON APTT, COAGULANT FACTOR ACTIVITY AND BLEEDING IN HEMOPHILIA
Danazol has been reported to raise several plasma proteins. Danazol was given orally at 600 mg/day in 3 divided doses to 6 hemophiliacs for 8-14 weeks. Factor levels, APTT and other laboratory parameters were ...
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Article
Treatment of patients with refractory myelogenous leukemia with BCOMM [1,3-bis-chloro(2-chloroethyl)-1-nitrosourea (BCNU), oncovin (vincristine), cyclophosphamide, high-dose methotrexate and methyl-glyoxal bis-guanylhydrazone (MGBG)]
Ten patients with AML refractory to anthracyclines and cytosine arabinoside were treated with vincristine 1.4 mg/m2 and methotrexate (MTX) 2.5 gm/m2 by intravenous (IV) bolus on day 1 [citrovorum factor (CF) resc...
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Article
Quantitative association between the in vitro human tumor stem cell assay and clinical response to cancer chemotherapy
Objective methods have been developed to quantitate results of the in vitro human tumor stem cell assay, the degree of the association between the in vitro assay and clinical response as well as the likelihood...
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Article
Altered Polyamine Metabolism in Cystic Fibrosis
Summary: Children with cystic fibrosis excreted elevated urinary levels of all three polyamines—putrescine, spermidine, and spermine. Heterozygote parents excreted intermediate concentrations of the polyamines...
