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  1. No Access

    Article

    Antiaggregant Activity of a New Benzimidazole Derivative

    Antiaggregant activity of a new tricyclic benzimidazole derivative, RU-891 compound, was studied on the model of ADP-induced platelet aggregation in vitro and intravascular platelet aggregation in vivo. We evalua...

    A. F. Kucheryavenko, A. A. Spasov… in Bulletin of Experimental Biology and Medic… (2014)

  2. No Access

    Article

    Antithrombogenic Activity of Antioxidant Compounds

    Antithrombotic activities of enoxifol, a new antioxidant with antiaggregant activity demonstrated in vitro and in vivo, and antioxidant mexidol were compared on the rat model of arterial thrombosis induced by app...

    A. A. Spasov, A. F. Kucheryavenko… in Bulletin of Experimental Biology and Medic… (2013)

  3. No Access

    Article

    Synthesis and Pharmacological Activity of Amino Alcohols of the Indole Series

    Opening of the oxirane ring in 1-oxiranylmethylindoles yielded new indole derivatives containing 1,2-amino alcohol residues at the nitrogen atom. Compounds were studied in vitro in relation to various types of...

    K. F. Suzdalev, A. A. Spasov, D. S. Yakovlev… in Pharmaceutical Chemistry Journal (2013)

  4. No Access

    Article

    Synthesis and pharmacological activity of amides of 2-amino-3-indolylacrylic acid

    Opening of the five-member ring of indolylmethyleneoxazolones with aliphatic amines was used to synthesize a series of amides of 2-amino-3-indolylacrylic acid. These compounds were studied in vitro in relation...

    A. A. Spasov, D. S. Yakovlev, K. F. Suzdalev… in Pharmaceutical Chemistry Journal (2013)

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    Article

    Synthesis and pharmacological activity of 3-(n,n-disubstituted)acetamide-1-r-2-aminobenzimidazolium chlorides

    A series of 3-(N,N-disubstituted)acetamide-1-R-2-aminobenzimidazolium chlorides were synthesized. Their pharmacological properties were studied. It was established that the synthesized substances decreased platel...

    V. A. Anisimova, A. A. Spasov, V. A. Kosolapov… in Pharmaceutical Chemistry Journal (2012)

  6. No Access

    Article

    Synthesis and pharmacological activity of salts of 3-acetyl-2-R-9-dialkylaminoethylimidazo[1,2-a]benzimidazoles

    New water-soluble 3-acetyl-2-R-9-dialkylaminoethylimidazo[1,2-a]benzimidazoles were synthesized on the basis of previously described structure-effect relationships among imidazobenzimidazole derivatives with h...

    V. A. Anisimova, A. A. Spasov, I. E. Tolpygin… in Pharmaceutical Chemistry Journal (2010)

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    Article

    Synthesis and pharmacological activity of 3-(2,2,2-trichloro-1-hydroxyethyl)imidazo [1, 2-a]benzimidazole dihydrochlorides

    Aseries of 3-(2,2,2-trichloro-1-hydroxyethyl)imidazo[1, 2-a]benzimidazole dihydrochlorides have been synthesized and their pharmacological properties have been studied. It is established that the synthesized comp...

    V. A. Anisimova, A. A. Spasov, V. A. Kosolapov… in Pharmaceutical Chemistry Journal (2009)

  8. No Access

    Article

    Synthesis and biological activity of N-acylmethyl derivatives of 9H-2,3-dihydroimidazo-and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles and their reduction products

    A series of N-acylmethyl derivatives of 9H-2,3-dihydroimidazo-and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles and products of their reduction has been synthesized and their pharmacological properties ...

    V. A. Anisimova, I. E. Tolpygin, A. A. Spasov… in Pharmaceutical Chemistry Journal (2006)

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    Article

    Synthesis and Pharmacological Activity of 2-Methoxyphenyl-Substituted 9-Dialkylaminoethylimidazo[1,2-a]benzimidazoles

    A series of 2-methoxyphenyl-9-dialkylaminoethyl derivatives of imidazo[1,2-a]benzimidazole have been synthesized and their pharmacological properties have been studied. Some of the synthesized compounds exhibi...

    V. A. Anisimova, A. A. Spasov, V. A. Kosolapov… in Pharmaceutical Chemistry Journal (2005)

  10. No Access

    Article

    Synthesis and Pharmacological Activity of 3-Aroyl- and 3-Hetaroylimidazo[1,2-a]benzimidazoles

    V. A. Anisimova, A. A. Spasov, O. V. Ostrovskii… in Pharmaceutical Chemistry Journal (2002)

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    Article

    Synthesis and Pharmacological Activity of 2-(Hetaryl)imidazo[1,2-a]benzimidazoles

    V. A. Anisimova, A. A. Spasov, A. F. Kucheryavenko… in Pharmaceutical Chemistry Journal (2002)

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