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Chapter
Extracorporeal Membrane Oxygenation: Set-up, Indications, and Complications
Extracorporeal membrane oxygenation (ECMO) occupies an increasingly important position in the clinic for the management of cardiac and/or pulmonary failure. As a rescue therapy, ECMO can support patients follo...
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Chapter
An Introduction to Engineering and Modeling the Lung
Over the last decade, the field of lung biology has evolved considerably due to many advancements, including the advent of single-cell RNA (scRNA) sequencing, induced pluripotent stem cell (iPSC) reprogramming...
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Chapter
Correction to: Lung Development in a Dish: Models to Interrogate the Cellular Niche and the Role of Mechanical Forces in Development
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Chapter
Lung Development in a Dish: Models to Interrogate the Cellular Niche and the Role of Mechanical Forces in Development
Over the past decade, emphasis has been placed on recapitulating in vitro the architecture and multicellular interactions found in organs in vivo [1, 2]. Whereas traditional reductionist approaches to in vitro...
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Chapter
Basic Science Perspective on Engineering and Modeling the Large Airways
The airway epithelium provides a physical and biochemical barrier playing a key role in protecting the lung from infiltration of pathogens and irritants and is, therefore, crucial in maintaining tissue homeost...
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Chapter
Engineering Large Airways
A key issue facing trachea replacement attempts has been the discrepancy of the mechanical properties between the native tracheal tissue and that of the replacement construct; this difference is often one of t...
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Chapter
Engineering Dynamic 3D Models of Lung
The lung parenchyma—consisting of gas-filled alveoli, vasculature, and connective tissue—is the site for gas exchange in the lung and plays a critical role in a number of chronic lung diseases. In vitro models...