3,550 Result(s)

Article

Clinical efficacy and identification of factors confer resistance to afatinib (tyrosine kinase inhibitor) in EGFR-overexpressing esophageal squamous cell carcinoma

Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal squamous cell carcinoma (ESCC) patients, but anti-EGFR treatments offer limited survival benefits. Our preclinical data sh...

Yanni Wang, Chang Liu, Huan Chen, ** Jiao… in Signal Transduction and Targeted Therapy (2024)

Article

Causal relationship between primary sclerosing cholangitis and systemic lupus erythematosus: a bidirectional Mendelian randomization study

Observational studies have found a link between two autoimmune diseases, namely, primary sclerosing cholangitis (PSC) and systemic lupus erythematosus (SLE). However, the relationship remains unclear.

Ziwen Pan, Weijie Zhang in European Journal of Medical Research (2024)

Article

Targeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8⁺ T cell effector differentiation and anti-tumor immunity

CD8⁺ T cell immune responses are regulated by multi-layer networks, while the post-translational regulation remains largely unknown. Transmembrane ectodomain shedding is an important post-translational process or...

Lina Sun, Anjun Jiao, Haiyan Liu, Renyi Ding… in Signal Transduction and Targeted Therapy (2024)

Article

Correction: Genomic alterations related to HPV infection status in a cohort of Chinese prostate cancer patients

Bin Lang, Chen Cao, **aoxiao Zhao, Yi Wang… in European Journal of Medical Research (2024)

Article

Association of α-HBDH levels with the severity and recurrence after acute ischemic stroke

α-HBDH serves as a biomarker of myocardial damage and is implicated in adverse outcomes across various critical illnesses. Our study aimed to assess the correlation between α-HBDH levels, and severity and recu...

Qiang Wang, Ting Deng, Yuanyuan **e, Haitao Lu… in European Journal of Medical Research (2024)

Article

Suspected myometrial invasion on MRI is correlated with worse outcomes of fertility-preserving treatment in young women with endometrial cancer

Myometrial invasion of endometrial cancer (EC) impairs the effectiveness of progestin-based treatment and results in high risks of disease progression and relapse. However, it is difficult to decide whether my...

Chengcheng Ning, Zhiying Xu, Fenghua Ma, Qin Zhu… in Holistic Integrative Oncology (2024)

Article

Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer

Pancreatic cancer is one of the deadly malignancies with a significant mortality rate and there are currently few therapeutic options for it. The tumor microenvironment (TME) in pancreatic cancer, distinguishe...

Pengcheng Zhou, Xuanlong Du, Weilu Jia… in Signal Transduction and Targeted Therapy (2024)

Article

P4HA2 hydroxylates SUFU to regulate the paracrine Hedgehog signaling and promote B-cell lymphoma progression

Aberrations in the Hedgehog (Hh) signaling pathway are significantly prevailed in various cancers, including B-cell lymphoma. A critical facet of Hh signal transduction involves the dynamic regulation of the s...

Quanfu Li, Yiyang Liu, **gxian Wu, Zewen Zhu, Jianjun Fan, Linhui Zhai… in Leukemia (2024)

Article

Prospective clinical study of the efficacy and safety of different doses of PEG recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) for preventing leukopenia/neutropenia caused by concurrent chemoradiotherapy for cervical cancer

The efficacy and safety of different doses of PEG recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in the prevention of leukopenia/neutropenia during concurrent chemoradiotherapy for cervi...

Tingting Yu, Yiwei Zhang, Jiawen Li, Zhuo Li, Rui Tong in Holistic Integrative Oncology (2024)

Article

Correction: Overexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer

Wei Zhang, **ao‑Song Chen, Ying Wei, **ao‑Min Wang… in European Journal of Medical Research (2024)

Article

Personalized prediction of mortality in patients with acute ischemic stroke using explainable artificial intelligence

Research into the acute kidney disease (AKD) after acute ischemic stroke (AIS) is rare, and how clinical features influence its prognosis remain unknown. We aim to employ interpretable machine learning (ML) mo...

Lingyu Xu, Chenyu Li, Jiaqi Zhang, Chen Guan… in European Journal of Medical Research (2024)

Article

Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets

Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring clonal advantage as the initial event. However, despite pervasive somatic mutations and clonal expansion in normal tis...

Shaosen Zhang, **nyi **ao, Yonglin Yi… in Signal Transduction and Targeted Therapy (2024)

Article

Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation

The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance of intra-tumoral bacteria, such us E.coli, residing and resulting in Colorectal cancer liver me...

Jian Gu, **aozhang Xu, **angyu Li, Lei Yue, **aowen Zhu, Qiuyang Chen, Ji Gao… in Oncogene (2024)

Article

Association analyses of apolipoprotein E genotypes and cognitive performance in patients with Parkinson’s disease

Cognitive impairment is a common non-motor symptom of Parkinson’s disease (PD). The apolipoprotein E (APOE) ε4 genotype increases the risk of Alzheimer’s disease (AD). However, the effect of APOEε4 on cognitiv...

Shi-Guo Zhu, Zhu-Ling Chen, Ke **ao, Zi-Wei Wang… in European Journal of Medical Research (2024)

Article

Ischemic cardio-cerebrovascular disease and all-cause mortality in Chinese elderly patients: a propensity-score matching study

Ischemic cardio-cerebrovascular disease is the leading cause of mortality worldwide. However, studies focusing on elderly and very elderly patients are scarce. Hence, our study aimed to characterize and invest...

Qian Yang, Shasha Sun, Long-Biao Cui, Shan Gao… in European Journal of Medical Research (2024)

Article

METTL3-mediated N⁶-methyladenosine modification of STAT5A promotes gastric cancer progression by regulating KLF4

N⁶-methyladenosine (m⁶A) is the predominant post-transcriptional RNA modification in eukaryotes and plays a pivotal regulatory role in various aspects of RNA fate determination, such as mRNA stability, alternativ...

Yichen Zang, Zhuangfei Tian, Dandan Wang, Yaxuan Li, Wenhui Zhang, Cunying Ma… in Oncogene (2024)

Article

Neoadjuvant camrelizumab (an anti-PD-1 antibody) plus chemotherapy or apatinib (a VEGFR-2 inhibitor) for initially unresectable stage II–III non-small-cell lung cancer: a multicentre, two-arm, phase 2 exploratory study

This multicentre, two-arm, phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in patients with initially unresectable stage II–III non-small-cell l...

Haoran **a, Han Zhang, Zheng Ruan… in Signal Transduction and Targeted Therapy (2024)

Article

Associations between deep venous thrombosis and thyroid diseases: a two-sample bidirectional Mendelian randomization study

Some previous observational studies have linked deep venous thrombosis (DVT) to thyroid diseases; however, the findings were contradictory. This study aimed to investigate whether some common thyroid diseases ...

Lifeng Zhang, Kaibei Li, Qifan Yang, Yao Lin… in European Journal of Medical Research (2024)