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  1. No Access

    Chapter and Conference Paper

    Endothelzellstimulation durch AGE — Ein In-vitro-Modell diabetischer Spätschäden

    Nichtenzymatische Glykosilierung führt zur Bildung von AGE-Proteinen. AGE-Proteine werden über spezifische Rezeptoren, die am Endothel und Makrophagen vorkommen, gebunden, internalisiert und degradiert. AGE-Pr...

    P. P. Nawroth, J. Lu, M. Abel, Y. Zhang, J. Riedesel F.z.E. in Diabetes und Angiopathie (1993)

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    Chapter

    Synthesis and Characterization of IGF-II Analogs: Applications in the Evaluation of IGF Receptor Function and IGF-Independent Actions of IGFBPS

    The elucidation of the mechanisms involved in the biological actions of the IGFs has been hampered by the complexity of the IGF system: three peptide ligands (IGF-I, IGF-II and insulin),1 three receptors (type 1 ...

    Youngman Oh, Hermann L. Müller, He** Zhang in Current Directions in Insulin-Like Growth … (1993)

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    Chapter

    Regulation of Cytoplasmic Free Ca2+ in Insulin-Secreting Cells

    The cytoplasmic free Ca2+ concentration([Ca2+]i) has a fundamental role in the β-cell stimulus-secretion coupling and is regulated by a sophisticated interplay between nutrients, hormones and neurotransmitters. M...

    Per-Olof Berggren, Per Arkhammar in New Concepts in the Pathogenesis of NIDDM (1993)

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    Chapter

    Substrates and the Regulation of Hepatic Glycogen Metabolism

    Hepatic glycogen has traditionally been considered as the storage form of glucose when an excess of carbohydrate is available, as after meals. In the post-absorptive period glucose is released from glycogen by...

    Jerry Radziuk, Susan Pye, Zi Zhang in New Concepts in the Pathogenesis of NIDDM (1993)

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    Article

    Abstracts of papers

    Nico P. E. Vermeulen., G. M. Donné-Op den Kelder in Pharmacy World and Science (1993)

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    Article

    Resistance Mechanism of MRSA to Quinolones

    Yong-xin Zhang, De-mei Zhu, Fu Wang, Mayumi Tanaka, Kenichi Sato, Yasuaki Osada in Drugs (1993)

  7. Article

    A glucose monitoring system for on line estimation in man of blood glucose concentration using a miniaturized glucose sensor implanted in the subcutaneous tissue and a wearable control unit

    We have developed a miniaturized glucose sensor which has been shown previously to function adequately when implanted in the subcutaneous tissue of rats and dogs. Following a glucose load, the sensor output in...

    V. Poitout, D. Moatti-Sirat, G. Reach, Y. Zhang, G. S. Wilson, F. Lemonnier in Diabetologia (1993)

  8. Article

    Alloxan cytotoxicity is highly potentiated by plasma membrane- and lysosomal-associated iron — a study on a model system of cultured J-774 cells

    Pancreatic islet beta cells, and some other cell types, are sensitive to the damaging effects of alloxan. The mechanisms behind the cytotoxicity have not been fully elucidated, although they are considered to ...

    H. Zhang, U. T. Brunk in Diabetologia (1993)

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    Article

    Abstracts of oral presentations

    R. Boulieu, A. Lenoir, J. F. Mornex, C. Bohman, J. Balzarini in Pharmacy World and Science (1993)

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    Article

    Abstracts of papers Pharmacological Meeting

    W. A. Bax, P. R. Saxena, Gerreke Ph. Biewenga, Jan de Jong in Pharmacy World and Science (1993)

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    Article

    Terfenadine: A mixture of equipotent antihistamine enantiomers without a clear ‘isomeric ballast’

    Terfenadine was the first non-sedating histamine H1 receptor antagonist and one of the most frequently prescribed H1 antihistamines. Terfenadine has one asymmetric centre in the molecule and is currently used as ...

    Dr. Ming-Qiang Zhang, Prof. Dr. Henk Timmerman in Pharmacy World and Science (1993)

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    Article

    Use of eye muscle antibody measurements to monitor response to plasmapheresis in patients with thyroid-associated ophthalmopathy

    We have measured eye muscle antibodies, in immunoblotting, in the serum from five patients with severe ophthalmopathy associated with Graves’ hyperthyroidism who underwent plasmapheresis, correlating their lev...

    Ç Atabay, M. Schrooyen, Z. G. Zhang, M. Salvi in Journal of Endocrinological Investigation (1993)

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    Article

    Effects of an anti-interleuktn-6 (IL-6) murine monoclonal antibody in a patient with acute monoblastic leukemia

    Because IL-6 has been involved in the pathogenesis of acute monoblastic leukemia, we investigated thein vitro anti-proliferative effect and thein vivo anti-tumoral effect of an anti-IL-6 murine monoclonal antibod...

    R. Bataille, X. G. Zhang, J. Wijdenes in Medical Oncology and Tumor Pharmacotherapy (1993)

  14. No Access

    Chapter

    Endothelial Cell Function in the Critically Ill

    Our concepts have changed markedly since W. Harvey’s original description of the vasculature as a passive conduit for blood to the vital organs. The endothelium of the vasculature represents a complex organ sy...

    J.-L. Vincent, J. C. Preiser, G. Friedman, H. Zhang in Sepsis (1994)

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    Article

    13th all Ireland social medicine meeting

    J. Prichard, S. Allwright, M. NcSweeney, D. Macleod in Irish Journal of Medical Science (1994)

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    Article

    Absorption Kinetics of Low Dose Aspirin in Patients with Evolving Acute Myocardial Infarction

    Administration of aspirin in patients with evolving acute myocardial infarction (AMI) has been associated with reduced short and long term mortality. Neither the mechanism of the beneficial effect of aspirin n...

    Dr C. L. Zhang, K. M. Wilson, I. Stafford, F. Bochner, J. D. Horowitz in Drug Investigation (1994)

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    Article

    Recurrence after resection ofα-fetoprotein-positive hepatocellular carcinoma

    The long-term prognosis of surgery for hepatocellular carcinoma (HCC) is not yet satisfactory, the main reason being the high recurrence rate. The authors report the results of a long-term follow-up of 308 pat...

    **n-Da Zhou, Zhao-You Tang, Ye-Qin Yu in Journal of Cancer Research and Clinical On… (1994)

  18. Article

    Variable regulation by insulin of insulin gene expression in HIT-T15 cells

    Glucose and insulin are generally considered to express opposite effects on insulin synthesis and secretion from pancreatic islets. For the most part this generalization has arisen from short-term experiments....

    H. -J. Zhang, B. Petersen, R. P. Robertson in Diabetologia (1994)

  19. Article

    Reduction of acetaminophen interference in glucose sensors by a composite Nafion membrane: demonstration in rats and man

    Amperometric glucose sensors typically monitor the production of hydrogen peroxide generated in the course of the enzymatic oxidation of glucose. At the applied potential necessary to oxidize the peroxide prod...

    D. Moatti-Sirat, V. Poitout, V. Thomé, M. N. Gangnerau, Y. Zhang, Y. Hu in Diabetologia (1994)

  20. Article

    Non-linkage of the glucagon-like peptide 1 receptor gene with maturity onset diabetes of the young

    Glucagon-like peptide-1 (GLP-1) is a hormone derived from the preproglucagon molecule that is secreted by intestinal L cells and stimulates insulin secretion from betacells. The GLP-1 receptor is a candidate g...

    Y. Zhang, J. T. E. Cook, A. T. Hattersley, R. Firth, P. J. Saker in Diabetologia (1994)

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