17,318 Result(s)
-
Chapter and Conference Paper
Endothelzellstimulation durch AGE — Ein In-vitro-Modell diabetischer Spätschäden
Nichtenzymatische Glykosilierung führt zur Bildung von AGE-Proteinen. AGE-Proteine werden über spezifische Rezeptoren, die am Endothel und Makrophagen vorkommen, gebunden, internalisiert und degradiert. AGE-Pr...
-
Chapter
Synthesis and Characterization of IGF-II Analogs: Applications in the Evaluation of IGF Receptor Function and IGF-Independent Actions of IGFBPS
The elucidation of the mechanisms involved in the biological actions of the IGFs has been hampered by the complexity of the IGF system: three peptide ligands (IGF-I, IGF-II and insulin),1 three receptors (type 1 ...
-
Chapter
Regulation of Cytoplasmic Free Ca2+ in Insulin-Secreting Cells
The cytoplasmic free Ca2+ concentration([Ca2+]i) has a fundamental role in the β-cell stimulus-secretion coupling and is regulated by a sophisticated interplay between nutrients, hormones and neurotransmitters. M...
-
Chapter
Substrates and the Regulation of Hepatic Glycogen Metabolism
Hepatic glycogen has traditionally been considered as the storage form of glucose when an excess of carbohydrate is available, as after meals. In the post-absorptive period glucose is released from glycogen by...
-
Article
Abstracts of papers
-
Article
Resistance Mechanism of MRSA to Quinolones
-
Article
A glucose monitoring system for on line estimation in man of blood glucose concentration using a miniaturized glucose sensor implanted in the subcutaneous tissue and a wearable control unit
We have developed a miniaturized glucose sensor which has been shown previously to function adequately when implanted in the subcutaneous tissue of rats and dogs. Following a glucose load, the sensor output in...
-
Article
Alloxan cytotoxicity is highly potentiated by plasma membrane- and lysosomal-associated iron — a study on a model system of cultured J-774 cells
Pancreatic islet beta cells, and some other cell types, are sensitive to the damaging effects of alloxan. The mechanisms behind the cytotoxicity have not been fully elucidated, although they are considered to ...
-
Article
Abstracts of oral presentations
-
Article
Abstracts of papers Pharmacological Meeting
-
Article
Terfenadine: A mixture of equipotent antihistamine enantiomers without a clear ‘isomeric ballast’
Terfenadine was the first non-sedating histamine H1 receptor antagonist and one of the most frequently prescribed H1 antihistamines. Terfenadine has one asymmetric centre in the molecule and is currently used as ...
-
Article
Use of eye muscle antibody measurements to monitor response to plasmapheresis in patients with thyroid-associated ophthalmopathy
We have measured eye muscle antibodies, in immunoblotting, in the serum from five patients with severe ophthalmopathy associated with Graves’ hyperthyroidism who underwent plasmapheresis, correlating their lev...
-
Article
Effects of an anti-interleuktn-6 (IL-6) murine monoclonal antibody in a patient with acute monoblastic leukemia
Because IL-6 has been involved in the pathogenesis of acute monoblastic leukemia, we investigated thein vitro anti-proliferative effect and thein vivo anti-tumoral effect of an anti-IL-6 murine monoclonal antibod...
-
Chapter
Endothelial Cell Function in the Critically Ill
Our concepts have changed markedly since W. Harvey’s original description of the vasculature as a passive conduit for blood to the vital organs. The endothelium of the vasculature represents a complex organ sy...
-
Article
13th all Ireland social medicine meeting
-
Article
Absorption Kinetics of Low Dose Aspirin in Patients with Evolving Acute Myocardial Infarction
Administration of aspirin in patients with evolving acute myocardial infarction (AMI) has been associated with reduced short and long term mortality. Neither the mechanism of the beneficial effect of aspirin n...
-
Article
Recurrence after resection ofα-fetoprotein-positive hepatocellular carcinoma
The long-term prognosis of surgery for hepatocellular carcinoma (HCC) is not yet satisfactory, the main reason being the high recurrence rate. The authors report the results of a long-term follow-up of 308 pat...
-
Article
Variable regulation by insulin of insulin gene expression in HIT-T15 cells
Glucose and insulin are generally considered to express opposite effects on insulin synthesis and secretion from pancreatic islets. For the most part this generalization has arisen from short-term experiments....
-
Article
Reduction of acetaminophen interference in glucose sensors by a composite Nafion membrane: demonstration in rats and man
Amperometric glucose sensors typically monitor the production of hydrogen peroxide generated in the course of the enzymatic oxidation of glucose. At the applied potential necessary to oxidize the peroxide prod...
-
Article
Non-linkage of the glucagon-like peptide 1 receptor gene with maturity onset diabetes of the young
Glucagon-like peptide-1 (GLP-1) is a hormone derived from the preproglucagon molecule that is secreted by intestinal L cells and stimulates insulin secretion from betacells. The GLP-1 receptor is a candidate g...