152 Result(s)

Article

Single-cell omics traces the heterogeneity of prostate cancer cells and the tumor microenvironment

Prostate cancer is one of the more heterogeneous tumour types. In recent years, with the rapid development of single-cell sequencing and spatial transcriptome technologies, researchers have gained a more intui...

Xudong Yu, Ruijia Liu, Wenfeng Gao, Xuyun Wang… in Cellular & Molecular Biology Letters (2023)

Article

Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury

Limited progress in terms of an effective treatment for spinal cord injury (SCI) emphasizes the urgent need for novel therapies. As a vital central nervous system component, the resident astrocytes play crucia...

Jie Chang, Zhanyang Qian, Binyu Wang, Jiang Cao… in Cell Communication and Signaling (2023)

Article

NSUN2 promotes osteosarcoma progression by enhancing the stability of FABP5 mRNA via m⁵C methylation

5-methylcytosine (m⁵C) modification, which is mainly induced by the RNA methyltransferase NSUN2 (NOP2/Sun domain family, member 2), is an important chemical posttranscriptional modification in mRNA and has been p...

Min Yang, Renxiong Wei, Sheng Zhang, Sang Hu, **aoxiao Liang… in Cell Death & Disease (2023)

Article

Targeting tumor-associated macrophages in hepatocellular carcinoma: biology, strategy, and immunotherapy

Hepatocellular carcinoma (HCC), one of the most malignant tumors, is characterized by its stubborn immunosuppressive microenvironment. As one of the main members of the tumor microenvironment (TME) of HCC, tum...

Hongyu Zheng, Xueqiang Peng, Shuo Yang, **nyu Li, Mingyao Huang… in Cell Death Discovery (2023)

Article

Hsa_circ_0021727 (circ-CD44) promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NFκB pathway

Esophageal squamous cell carcinoma (ESCC) is characterized by high morbidity and mortality. Circular RNAs (circRNAs) play an important role in tumor progression. We discovered an aberrantly expressed circRNA (...

Fan Meng, **aokang Zhang, Yanting Wang, Jie Lin, Yulin Tang… in Cell Death & Disease (2023)

Article

FTO stabilizes MIS12 and counteracts senescence

Sheng Zhang, Zeming Wu, Yue Shi, Si Wang, Jie Ren, Zihui Yu… in Protein & Cell (2022)

Article

Correction: Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats

**ang-Sheng Zhang, Qi Wu, Ling-Yun Wu, Zhen-Nan Ye, Tian-Wei Jiang… in Cell Death & Disease (2022)

Article

Identification of circular RNA BTBD7_hsa_circ_0000563 as a novel biomarker for coronary artery disease and the functional discovery of BTBD7_hsa_circ_0000563 based on peripheral blood mononuclear cells: a case control study

BTBD7_hsa_circ_0000563 is a novel circRNA and contains conserved binding sites with RNA-binding proteins. However, BTBD7_hsa_circ_0000563 has not been fully studied in coronary artery disease (CAD). We aimed t...

Hanxiao Zhou, **ongkang Gan, Shu He, Yanjun Wang, Sheng Zhang… in Clinical Proteomics (2022)

Article

Systematic comparation of the biological and transcriptomic landscapes of human amniotic mesenchymal stem cells under serum-containing and serum-free conditions

Human amniotic mesenchymal stem cells (hAMSCs) are splendid cell sources for clinical application in the administration of numerous refractory and relapse diseases. Despite the preferable prospect of serum-fre...

Yunyan Sun, Ti-er Wang, Qianwen Hu, Wenxia Zhang, Yun Zeng… in Stem Cell Research & Therapy (2022)

Article

CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway

Cancer-associated fibroblasts (CAFs) are the most abundant stromal components in the tumor microenvironment (TME) and closely involved in tumor progression. However, the precise biological functions and molecu...

Peng Yang, Dongsheng Zhang, Tuo Wang, Jiangzhou Ji, Chi **… in Cell Death & Disease (2022)

Article

Correction to: DC-SIGN–LEF1/TCF1–miR-185 feedback loop promotes colorectal cancer invasion and metastasis

A Correction to this paper has been published: https://doi.org/10.1038/s41418-021-00736-9

Menglang Yuan, **nsheng Zhang, **gbo Zhang, Keyong Wang… in Cell Death & Differentiation (2022)

Article

Correction: Transcription factor EB-mediated mesenchymal stem cell therapy induces autophagy and alleviates spinocerebellar ataxia type 3 defects in neuronal cells model

**aobo Han, Jean de Dieu Habimana, Amy L. Li, Rongqi Huang… in Cell Death & Disease (2022)

Article

Recent advances in proteomics and metabolomics in plants

Over the past decade, systems biology and plant-omics have increasingly become the main stream in plant biology research. New developments in mass spectrometry and bioinformatics tools, and methodological sche...

Shijuan Yan, Ruchika Bhawal, Zhibin Yin, Theodore W. Thannhauser… in Molecular Horticulture (2022)

Article

Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury

Coenzyme Q10 (CoQ10), an endogenous antioxidant, has been reported frequently to exert an outstanding protective effect on multiple organ injury, including acute kidney injury (AKI). In this study, we aim to s...

Shankun Zhao, Weizhou Wu, Jian Liao, **nsheng Zhang… in Cellular & Molecular Biology Letters (2022)

Article

Transcription factor EB-mediated mesenchymal stem cell therapy induces autophagy and alleviates spinocerebellar ataxia type 3 defects in neuronal cells model

Defects in ataxin-3 proteins and CAG repeat expansions in its coding gene ATXN3 cause Spinocerebellar Ataxia Type 3 (SCA3) or Machado-Joseph disease (MJD) polyglutamine neurodegenerative disease. The mutant pr...

**aobo Han, Jean de Dieu Habimana, Amy L. Li, Rongqi Huang… in Cell Death & Disease (2022)

Article

MicroRNA-206 down-regulated human umbilical cord mesenchymal stem cells alleviate cognitive decline in D-galactose-induced aging mice

Non-pathological cognitive decline is a neurodegenerative condition associated with brain aging owing to epigenetic changes, telomere shortening, stem cells exhaustion, or altered differentiation. Human umbili...

Yuying Zhang, Weiyue Deng, Wei Wang, Aishi Song, Omar Mukama… in Cell Death Discovery (2022)

Article

BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1

Dysregulated osteoclast activity due to altered osteoclast differentiation causes multiple bone diseases. Osteoclasts are multinucleated giant cells derived from hematopoietic stem cells and play a major role ...

Yufeng Zhang, Min Yang, Sheng Zhang, Zhiqiang Yang, Yufan Zhu, Yi Wang… in Cell & Bioscience (2022)