58 Result(s)
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Article
Open AccessThe role of Sphingomyelin synthase 2 (SMS2) in platelet activation and its clinical significance
Sphingomyelin (SM) is an essential component of biological lipid rafts, and it plays an indispensable role in maintaining plasma membrane stability and in mediating signal transduction. The ultimate biosynthes...
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Open AccessTrans-scapular approach coil localization for scapular-blocked pulmonary nodules: a retrospective study
Preoperative computed tomography (CT)-guided coil localization (CL) is commonly used to facilitate video-assisted thoracoscopic surgery (VATS)-guided diagnostic wedge resection (WR) of pulmonary nodules (PNs)....
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Open AccessSTAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17
In tauopathies, memory impairment positively strongly correlates with the amount of abnormal tau aggregates; however, how tau accumulation induces synapse impairment is unclear. Recently, we found that human t...
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Open AccessKindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice
In vertebrates, the type 1 parathyroid hormone receptor (PTH1R) is a critical regulator of skeletal development and homeostasis; however, how it is modulated is incompletely understood. Here we report that del...
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Open AccessEfficacy of closed reduction for developmental dysplasia of the hip: midterm outcomes and risk factors associated with treatment failure and avascular necrosis
The purpose of this study was to evaluate the efficacy of closed reduction (CR) in the treatment of developmental dysplasia of the hip (DDH) and to investigate risk factors associated with CR failure and avasc...
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Article
Open AccessUltrasonography-guided closed reduction in the treatment of displaced transphyseal fracture of the distal humerus
To evaluate the clinical and radiographic outcomes of ultrasonography-guided closed reduction in the treatment of displaced transphyseal fracture of the distal humerus (TFDH).
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Article
Association of Genetic Risk of Obesity with Postoperative Complications Using Mendelian Randomization
The extent to which obesity and genetics determine postoperative complications is incompletely understood.
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Systems-Based Interactome Analysis for Hematopoiesis Effect of Angelicae sinensis Radix: Regulated Network of Cell Proliferation towards Hemopoiesis
To explore the molecular-level mechanism on the hematopoiesis effect of Angelicae sinensis Radix (ASR) with systems-based interactome analysis.
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Open AccessEfficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: prediction with network pharmacology and validation in a clinical trial
Leflunomide (LEF) is a first-line disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis (RA). However, there are still a few nonresponders. It is logical to suggest that employing combinations ...
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Article
Spontaneous premature birth as a target of genomic research
Spontaneous preterm birth is a serious and common pregnancy complication associated with hormonal dysregulation, infection, inflammation, immunity, rupture of fetal membranes, stress, bleeding, and uterine dis...
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Article
Positive association between serum uric acid and bone mineral density in Chinese type 2 diabetes mellitus stratified by gender and BMI
Accumulating evidence has demonstrated that serum uric acid (UA), a natural powerful antioxidant, plays a beneficial role in bone health in the general population. However, few reports are available on the ass...
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Open AccessAntimicrobial susceptibilities of aerobic and facultative gram-negative bacilli isolated from Chinese patients with urinary tract infections between 2010 and 2014
The objective of this study was to investigate the distribution and susceptibility of aerobic and facultative Gram-negative bacilli isolated from Chinese patients with UTIs collected within 48 h (community acq...
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Histone deacetylase inhibitors deplete myeloid-derived suppressor cells induced by 4T1 mammary tumors in vivo and in vitro
Myeloid-derived suppressor cells (MDSC) have been identified as a population of immature myeloid cells that suppress anti-tumor immunity. MDSC are increased in tumor-bearing hosts; thus, depletion of MDSC may ...
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Article
Integration of chinese medicine with western medicine could lead to future medicine: molecular module medicine
The development of an effective classification method for human health conditions is essential for precise diagnosis and delivery of tailored therapy to individuals. Contemporary classification of disease syst...
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Open AccessVirtual screening of the inhibitors targeting at the viral protein 40 of Ebola virus
The Ebola virus is highly pathogenic and destructive to humans and other primates. The Ebola virus encodes viral protein 40 (VP40), which is highly expressed and regulates the assembly and release of viral par...
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Article
Genetic Architecture of Complex Human Traits: What Have We Learned from Genome-Wide Association Studies?
Genome-wide association studies have identified thousands of genetic variants associated with various complex human traits and diseases. These results opened a window to the genetic architecture of complex hum...
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Open AccessValidation and clinicopathologic associations of a urine-based bladder cancer biomarker signature
To validate the expression of a urine-based bladder cancer associated diagnostic signature comprised of 10 targets; ANG, CA9, MMP9, MMP10, SERPINA1, APOE, SDC1, VEGFA, SERPINE1 and IL8 in bladder tumor tissues.
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Leukemias involving abdominal and pelvic lymph nodes: evaluation with contrast-enhanced MDCT
To clarify features of lymph nodes associated with leukemia purposing to offer help for imaging diagnosis and differential diagnosis of leukemia.
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Progress and perspectives of biomarker discovery in Chinese medicine research
Biomarker discovery in Chinese medicine (CM) has recently attracted a great deal of attention, owing to the promise of high-throughput technologies development and the potential of Chinese herbal medicine. Fur...
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Open AccessFei-Liu-** ointment inhibits lung cancer growth and invasion by suppressing tumor inflammatory microenvironment
Lung cancer is one of the leading causes of cancer-related mortality worldwide. Conventional chemotherapy and radiotherapy are the primary therapeutic methods for lung cancer with the use of combination therap...
