101 Result(s)

Article

Single-cell RNA sequencing in cancer research: discovering novel biomarkers and therapeutic targets for immune checkpoint blockade

Immune checkpoint blockade (ICB) has become a promising strategy in treating advanced cancers, providing significant survival benefits for patients with various cancer types. However, among the vast population...

Boyu Sun, Ziyu Xun, Nan Zhang, Kai Liu, **angqi Chen… in Cancer Cell International (2023)

Article

Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy

In the early stages of diabetic retinopathy (DR), diabetes-related hyperglycemia directly inhibits the AKT signaling pathway by increasing oxidative stress or inhibiting growth factor expression, which leads t...

Jiayuan Li, Kuangqi Chen, **ang Li, Xuhong Zhang, Liyue Zhang… in Cell Death Discovery (2023)

Article

Progress and challenges in energy storage and utilization via ammonia

Ammonia is a premium energy carrier with high content of hydrogen. However, energy storage and utilization via ammonia still confront multiple challenges. Here, we review recent progress and discuss challenges...

Chongqi Chen, Yanliang Zhou, Huihuang Fang, **aobo Peng… in Surface Science and Technology (2023)

Article

Aptamer-based self-assembled nanomicelle enables efficient and targeted drug delivery

Nucleic acid aptamer-based nanomicelles have great potential for nanomedicine and nanotechnology applications. However, amphiphilic aptamer micelles are known to be inherently unstable upon interaction with ce...

Ganghui Chen, Dongsheng Mao, Xuan Wang, **gqi Chen… in Journal of Nanobiotechnology (2023)

Article

Exogenous IL-25 ameliorates airway neutrophilia via suppressing macrophage M1 polarization and the expression of IL-12 and IL-23 in asthma

Severe asthma is associated with substantial mortality and has unmet therapeutic need. A subset of severe asthma is characterized by neutrophilic airway inflammation. Classically activated (or M1) macrophages ...

Chenli Chang, Gongqi Chen, Wenliang Wu, Dian Chen, Shengchong Chen… in Respiratory Research (2023)

Article

Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of death in the world. In most cases, drug resistance and tumor recurrence are ultimately inevitable. One obstacle is the pr...

** Lu, Lei Zhong, Emma Lindell, Margus Veanes, **g Guo, Miao Zhao… in Cell Death & Disease (2023)

Article

CACA guidelines for holistic integrative management of esophageal carcinoma

Esophageal carcinoma (EC) is a common malignant tumor of the upper digestive tract worldwide. An analysis of the latest data from cancer centers in China showed that the incidence of EC and the number of death...

Lei Gong, Ming Bai, Liang Dai, Xufeng Guo, Xuefeng Leng… in Holistic Integrative Oncology (2023)

Article

Comprehensive landscape of resistance mechanisms for neoadjuvant therapy in esophageal squamous cell carcinoma by single-cell transcriptomics

Yushang Yang, Yanguo Li, Haopeng Yu… in Signal Transduction and Targeted Therapy (2023)

Article

Metallic nanoplatforms for COVID-19 diagnostics: versatile applications in the pandemic and post-pandemic era

The COVID-19 pandemic, which originated in Hubei, China, in December 2019, has had a profound impact on global public health. With the elucidation of the SARS-CoV-2 virus structure, genome type, and routes of ...

Yuqing Li, **gqi Chen, **chao Wei, Xueliang Liu, Lu Yu… in Journal of Nanobiotechnology (2023)

Article

Predicting the storage time of green tea by myricetin based on surface-enhanced Raman spectroscopy

The quality of green tea changes rapidly due to the oxidation and degradation of polyphenols during storage. Herein, a simple and fast Surface-enhanced Raman spectroscopy (SERS) strategy was established to pre...

Mengxuan **ao, Yingqi Chen, Fangling Zheng, Qi An, Mingji **ao… in npj Science of Food (2023)

Article

An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment

Intra-articular injection of therapeutics is an effective strategy for treating osteoarthritis (OA), but it is hindered by rapid drug diffusion, thereby necessitating high-frequency injections. Hence, the deve...

Guoqing Li, Su Liu, Yixiao Chen, ** Zhao, Huihui Xu, Jian Weng… in Nature Communications (2023)

Article

Apatinib plus etoposide in pretreated patients with advanced triple-negative breast cancer: a phase II trial

Treatment options for pretreated triple-negative breast cancer (TNBC) are limited. This study aimed to evaluate the efficacy and safety of apatinib, an antiangiogenic agent, in combination of etoposide for pre...

Mengru Cao, Hailing Lu, Shi Yan, Hui Pang, Lichun Sun, Chunhong Li… in BMC Cancer (2023)

Article

Attitudes and influencing factors of nursing assistants towards hospice and palliative care nursing in chinese nursing homes: a cross-sectional study

Hospice and palliative care nursing (HPCN) in China is mainly available at public primary care institutions, where nursing homes (NHs) are rarely involved. Nursing assistants (NAs) play an essential role in HP...

Zhuojun Ye, Limei **g, Haoyu Zhang, Yongfa Qin, Hangqi Chen… in BMC Palliative Care (2023)

Article

Construction and analysis of a nomogram prediction model for post-infectious bronchiolitis obliterans in children with adenovirus pneumonia after invasive mechanical ventilation

Post-infectious bronchiolitis obliterans (PIBO) is the most common sequelae in children with adenovirus pneumonia (ADVP). However, there are few studies on the risk factors for PIBO occurrence. This study aims...

Li Peng, Silan Liu, Tian **e, Yu Li, Zhuojie Yang, Yongqi Chen… in BMC Pediatrics (2023)

Article

MMP2 is a immunotherapy related biomarker and correlated with cancer-associated fibroblasts infiltrate in melanoma

Mounting evidence supports that matrix metalloproteinase (MMPs) are highly associated with tumor progression and that targeting MMPs may overcome the barrier of immune suppression. Among these, whether MMP2 fu...

Kunwei Peng, Yanyan Zhang, Deyi Liu, **gqi Chen in Cancer Cell International (2023)

Article

TadA orthologs enable both cytosine and adenine editing of base editors

Cytidine and adenosine deaminases are required for cytosine and adenine editing of base editors respectively, and no single deaminase could enable concurrent and comparable cytosine and adenine editing. Additi...

Shuqian Zhang, Bo Yuan, Jixin Cao, Liting Song, **long Chen… in Nature Communications (2023)

Article

TadA reprogramming to generate potent miniature base editors with high precision

Although miniature CRISPR-Cas12f systems were recently developed, the editing efficacy and targeting range of derived miniature cytosine and adenine base editors (miniCBEs and miniABEs) have not been comprehen...

Shuqian Zhang, Liting Song, Bo Yuan, Cheng Zhang, Jixin Cao… in Nature Communications (2023)

Article

Correction: Mucus-Penetrating Alginate-Chitosan Nanoparticles Loaded with Berberine Hydrochloride for Oral Delivery to the Inflammation Site of Ulcerative Colitis

Lingfeng Sun, **angjiang Nie, Wenjie Lu, Qing Zhang, Wenyou Fang… in AAPS PharmSciTech (2022)

Article

Assessing the Activity of Antimicrobial Peptides Against Common Marine Bacteria Located in Rotifer (Brachionus plicatilis) Cultures

Rotifers are used as the first feed for marine fish larvae and are grown in large cultures that have high loads of organic matter and heterotrophic bacteria; these bacteria are passed on to the develo** fish...

Chelsea Woods, Lindsey Woolley, Gavin Partridge… in Probiotics and Antimicrobial Proteins (2022)

Article

Inter-row navigation line detection for cotton with broken rows

The application of autopilot technology is conductive to achieving path planning navigation and liberating labor productivity. In addition, the self-driving vehicles can drive according to the growth state of ...

**huizi Liang, Bingqi Chen, Chaojie Wei, **ongchu Zhang in Plant Methods (2022)