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Article
New horizons for the role of RNA N6-methyladenosine modification in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignancy, presenting a formidable challenge to the medical community owing to its intricate pathogenic mechanisms. Although current prevention, survei...
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Article
The effect of secondary phase on corrosion behaviors of the titanium–zirconium–molybdenum alloy
As the range of applications for molybdenum and its alloys has expanded, the corrosive environment for molybdenum alloys has become more demanding. In the past, the content of do** elements has been studied ...
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Article
Reward motivation adaptation in people with negative schizotypal features: development of a novel behavioural paradigm and identifying its neural correlates using resting-state functional connectivity analysis
Reward motivation in individuals with high levels of negative schizotypal traits (NS) has been found to be lower than that in their counterparts. But it is unclear that whether their reward motivation adaptive...
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Article
Weatherability and heat resistance enhanced by interaction between AG25 and Mg/Al-LDH
Although inorganic pigments in common spectral tuning materials show good weatherability and heat resistance, the limited color choices, weak coloring power, poor dispersibility, and a possibility of toxicity ...
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Article
Human amniotic epithelial stem cell is a cell therapy candidate for preventing acute graft-versus-host disease
Graft-versus-host disease (GVHD), an immunological disorder that arises from donor T cell activation through recognition of host alloantigens, is the major limitation in the application of allogeneic hematopoi...
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Article
Microstructure and texture evolution of Cu–Cr–Co–Ti alloys during the two-stage cryorolling
This study entailed an investigation of the mechanical properties, microstructural and texture orientation evolutions of Cu–Cr–Co–Ti alloys prepared via two-stage cryorolling and intermediate aging treatment. ...
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Article
Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting
Glucose-sensitive membrane has potential application in self-regulating insulin release. Phenylboronic acid (PBA) is a well-known glucose reporter. Unfortunately, most PBA-based glucose-sensitive materials are...
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Article
Outcomes of Salvage Surgery Versus Non-Salvage Surgery for Initially Unresectable Hepatocellular Carcinoma After Conversion Therapy with Transcatheter Arterial Chemoembolization Combined with Lenvatinib Plus Anti-PD-1 Antibody: A Multicenter Retrospective Study
Combination treatment with transcatheter arterial chemoembolization (TACE), lenvatinib, and anti-programmed death-1 (anti-PD-1) antibodies (triple therapy) has a high rate of tumor response and converted resec...
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Article
Diversification of interfaces triggered hydrogen storage properties enhancement
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Article
Prediction and predictability of boreal winter MJO using a multi-member subseasonal to seasonal forecast system of NUIST (NUIST CFS 1.1)
The Madden–Julian Oscillation (MJO) provides an important source of global subseasonal-to-seasonal (S2S) predictability, while its prediction remains great challenges. Based on an atmosphere–ocean coupled mode...
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Article
Open AccessThe use of longitudinal CT-based radiomics and clinicopathological features predicts the pathological complete response of metastasized axillary lymph nodes in breast cancer
Accurate assessment of axillary status after neoadjuvant therapy for breast cancer patients with axillary lymph node metastasis is important for the selection of appropriate subsequent axillary treatment decis...
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Article
The level of CmFRQ is associated with the degeneration and rejuvenation of Cordyceps militaris fruiting body
Cordyceps militaris is a large fungus whose fruiting body is prone to degeneration. In the study of C. militaris FREQUENCY (CmFRQ), the negative regulator of C. militaris circadian clock, it was found that after ...
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Article
Comparison of Machine Learning Models Using Diffusion-Weighted Images for Pathological Grade of Intrahepatic Mass-Forming Cholangiocarcinoma
Is the radiomic approach, utilizing diffusion-weighted imaging (DWI), capable of predicting the various pathological grades of intrahepatic mass-forming cholangiocarcinoma (IMCC)? Furthermore, which model demo...
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Article
Open AccessPhotocatalytic Z/E isomerization unlocking the stereodivergent construction of axially chiral alkene frameworks
The past century has witnessed a large number of reports on the Z/E isomerization of alkenes. However, the vast majority of them are still limited to the isomerization of di- and tri-substituted alkenes. The ster...
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Article
Open AccessInterferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis
Liver ischemia/reperfusion (I/R) injury is usually caused by hepatic inflow occlusion during liver surgery, and is frequently observed during war wounds and trauma. Hepatocyte ferroptosis plays a critical role...
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Article
Open AccessXELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...
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Article
Open AccessThe Effect of Glycine and N-Acetylcysteine on Oxidative Stress in the Spinal Cord and Skeletal Muscle After Spinal Cord Injury
Oxidative stress is a frequently occurring pathophysiological feature of spinal cord injury (SCI) and can result in secondary injury to the spinal cord and skeletal muscle atrophy. Studies have reported that g...
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Article
Open AccessFOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury
Neutrophils are traditionally viewed as first responders but have a short onset of action in response to traumatic brain injury (TBI). However, the heterogeneity, multifunctionality, and time-dependent modulat...
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Article
Open AccessTranscranial alternating current stimulation improves quality of life in Parkinson’s disease: study protocol for a randomized, double-blind, controlled trial
The neural cells in the brains of patients with Parkinson’s disease (PWP) display aberrant synchronized oscillatory activity within the beta frequency range. Additionally, enhanced gamma oscillations may serve...
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Article
Open AccessLifestyle intervention in children with obesity and nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized controlled trial in Ningbo city (the SCIENT study)
The increasing prevalence of childhood obesity has become an urgent public health problem, evidence showed that intervention for childhood obesity bring enormous health benefits. However, an effective individu...
