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Article
Effect of Ce on microstructure and mechanical properties of Mg-Zn-Ce magnesium alloys
The Mg-6Zn alloy with different contents of Ce was prepared by the gravity casting method, and then the Mg-6Zn-xCe (x=0, 0.5, 1.0, 1.5, wt.%) alloys were extruded at 300 °C and 350 °C after solution treatment. Th...
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Article
Open AccessLong-distance spread of Tembusu virus, and its dispersal in local mosquitoes and domestic poultry in Chongming Island, China
Chongming Island in China serves as a breeding and shelter point on the East Asian–Australasian Flyway. The resting frequency of migratory birds, abundance of mosquito populations, and the popular domestic pou...
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Article
Author Correction: Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors
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Article
Open AccessTM4SF1 upregulates MYH9 to activate the NOTCH pathway to promote cancer stemness and lenvatinib resistance in HCC
TM4SF1, a member of the transmembrane 4 superfamily, is crucial for both healthy and malignant human tissues. The significant function of TM4SF1 in the incidence and progression of cancer has been widely recog...
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Article
Optimization of the Process for Preparing Bivalent Polysaccharide Conjugates to Develop Multivalent Conjugate Vaccines against Streptococcus pneumoniae or Neisseria meningitidis and Comparison with the Corresponding Licensed Vaccines in Animal Models
This study aimed to describe, optimize and evaluate a method for preparing multivalent conjugate vaccines by simultaneous conjugation of two different bacterial capsular polysaccharides (CPs) with tetanus toxo...
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Article
Open Accessscm6A-seq reveals single-cell landscapes of the dynamic m6A during oocyte maturation and early embryonic development
N6-methyladenosine (m6A) has been demonstrated to regulate RNA metabolism and various biological processes, including gametogenesis and embryogenesis. However, the landscape and function of m6A at single cell res...
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Article
Open AccessCpG-binding protein CFP1 promotes ovarian cancer cell proliferation by regulating BST2 transcription
Epigenetic alterations have been functionally linked to ovarian cancer development and occurrence. The CXXC zinc finger protein 1 (CFP1) is an epigenetic regulator involved in DNA methylation and histone modif...
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Article
Open AccessBoth indirect maternal and direct fetal genetic effects reflect the observational relationship between higher birth weight and lower adult bone mass
Birth weight is considered not only to undermine future growth, but also to induce lifelong diseases; the aim of this study is to explore the relationship between birth weight and adult bone mass.
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Article
Open AccessEfficient Visual Recognition: A Survey on Recent Advances and Brain-inspired Methodologies
Visual recognition is currently one of the most important and active research areas in computer vision, pattern recognition, and even the general field of artificial intelligence. It has great fundamental impo...
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Article
Open AccessThe crosstalk between endothelial cells and vascular smooth muscle cells aggravates high phosphorus-induced arterial calcification
Arterial calcification is highly prevalent, particularly in patients with end-stage renal disease (ESRD). The osteogenic differentiation of vascular smooth muscle cells (VSMCs) is the critical process for the ...
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Article
Open AccessSafety and feasibility of the transoral endoscopic thyroidectomy vestibular approach with neuroprotection techniques for papillary thyroid carcinoma
This study aimed to evaluate the feasibility and safety of the trans-oral endoscopic thyroidectomy vestibular approach (TOETVA) with neuroprotection techniques for the surgical management of papillary thyroid ...
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Open AccessProgress in ceramic materials and structure design toward advanced thermal barrier coatings
Thermal barrier coatings (TBCs) can effectively protect the alloy substrate of hot components in aeroengines or land-based gas turbines by the thermal insulation and corrosion/erosion resistance of the ceramic...
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Article
Open AccessPharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
HDAC inhibitors (HDACis) have been intensively studied for their roles and potential as drug targets in T-cell lymphomas and other hematologic malignancies. Bisthianostat is a novel bisthiazole-based pan-HDACi...
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Article
Open AccessBRD4 inhibitor GNE987 exerts anti-cancer effects by targeting super-enhancers in neuroblastoma
Neuroblastoma (NB) is a common extracranial malignancy with high mortality in children. Recently, super-enhancers (SEs) have been reported to play a critical role in the tumorigenesis and development of NB via...
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Article
Open AccessHigh prevalence and low awareness of hyperuricemia in hypertensive patients among adults aged 50–79 years in Southwest China
This study was aimed to assess the prevalence of hyperuricemia and its associated risk factors among hypertensive patients in Southwest China.
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Article
Open AccessComparative transcriptome and DNA methylation analysis in temperature-sensitive genic male sterile wheat BS366
Known as the prerequisite component for the heterosis breeding system, the male sterile line determines the hybrid yield and seed purity. Therefore, a deep understanding of the mechanism and gene network that ...
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Article
Open AccessThe design and sensitivity of JUNO’s scintillator radiopurity pre-detector OSIRIS
The OSIRIS detector is a subsystem of the liquid scintillator filling chain of the JUNO reactor neutrino experiment. Its purpose is to validate the radiopurity of the scintillator to assure that all components...
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Article
Open AccessDirect copolymerization of ethylene with protic comonomers enabled by multinuclear Ni catalysts
Ethylene/polar monomer coordination copolymerization offers an attractive way of making functionalized polyolefins. However, ethylene copolymerization with industrially relevant short chain length alkenoic aci...
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Article
Open Access3D Ultralight Hollow NiCo Compound@MXene Composites for Tunable and High-Efficient Microwave Absorption
Ultralight 3D NiCo compound@MXene nanocomposites that inherited hollow polyhedral skeleton and excellent conductive network were fabricated.
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Open AccessA cross-sectional study of olfactory and taste disorders among COVID-19 patients in China
To determine the prevalence and clinical features of olfactory and taste disorders among coronavirus disease 2019 (COVID-19) patients in China. A cross-sectional study was performed in Wuhan from April 3, 2020...
