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Article
FK228 potentiates topotecan activity against small cell lung cancer cells via induction of SLFN11
The response rate of topotecan, as a second-line chemotherapeutic drug for small cell lung cancer, is ~20%. DNA/RNA helicase SLFN11 (schlafen family member 11), a member of the Schlafen (SLFN) family, is a cru...
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Article
Open AccessBerberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota
Trimethylamine-N-oxide (TMAO) derived from the gut microbiota is an atherogenic metabolite. This study investigates whether or not berberine (BBR) could reduce TMAO production in the gut microbiota and treat athe...
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Article
Identification of a novel Calpain-2-SRC feed-back loop as necessity for β-Catenin accumulation and signaling activation in hepatocellular carcinoma
Rapid progression is the major cause of the poor prognosis of hepatocellular carcinoma (HCC); however, the underlying mechanism remained unclear. Here, we found Calpain-2 (CAPN2), a well-established protease t...
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Article
The effects of fish oil plus vitamin D3 intervention on non-alcoholic fatty liver disease: a randomized controlled trial
The present study aimed to investigate fish oil plus vitamin D3 (FO + D) supplementation on biomarkers of non-alcoholic fatty liver disease (NAFLD).
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Article
2D/2D heterostructured MoS2/PtSe2 promoting charge separation in FTO thin film for efficient and stable photocatalytic hydrogen evolution
开发稳定的光催化膜对与太阳能-氢能转化以及污染物降解具有重要的现实意义, 然而至今仍是一个大挑战。本工作采用热蒸与化学气相沉积 (CVD) 法在FTO上连续沉积MoS2和PtSe2制备一种稳定的MoS2/PtSe2/FTO光催化薄膜。优化的MoS2/PtSe2/FTO膜的光催化产氢速率1560 mmol·h−1·m−2, 远远高于FTO和其它单MX2/FTO。而且, MoS2/PtSe2/FTO膜具有良好的材料结构和性...
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Article
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the...
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Article
Associations of sleep disorders with cerebrospinal fluid α-synuclein in prodromal and early Parkinson’s disease
Our aim is to investigate the associations of sleep disorders with cerebrospinal fluid (CSF) α-synuclein (α-syn) in healthy controls (HCs), and patients with prodromal and early Parkinson’s disease (PD).
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Article
Open AccessClinical features and treatment outcomes of pediatric Langerhans cell histiocytosis with macrophage activation syndrome-hemophagocytic lymphohistiocytosis
Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm. A few LCH patients had Macrophage activation syndrome-hemophagocytic lymphohistiocytosis (MAS-HLH), a life-threatening, hyper-inflammatory syndro...
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Article
Harnessing chlorin e6 loaded by functionalized iron oxide nanoparticles linked with glucose for target photodynamic therapy and improving of the immunogenicity of lung cancer
Non-small-cell lung cancer (NSCLC) is the most common malignant lung tumor and is difficult to be eradicated due to its immunosuppressive microenvironment. Chlorin e6 (Ce6)-mediated photodynamic therapy (PDT) ...
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Article
Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-Sirt1/Sirt1 axis
Diosmetin (3',5,7 -trihydroxy-4'-methoxy flavone) is a natural flavonoid compound in the citrus species, it exhibits a variety of pharmacological activities, but little is known of its effects on colitis. In t...
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Article
Heterochiral peptide-based biocompatible and injectable supramolecular hydrogel with antibacterial activity
The bacterial infection has a significant impact on the human health. With the widespread use of antibiotics, the bacterial resistance has increased significantly, which necessitates the urgent identification ...
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Article
Rapid Determination of Sunset Yellow in Soft Drinks Using Silicon Nanoparticles Synthesized under Mild Conditions
Sunset yellow (SY) is a synthetic colorant which can cause allergies, diarrhea and other symptoms in sensitive people. When ingested too much, it can accumulate in the body and cause damage to the kidneys and ...
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Article
Application of topical gentamicin—a new era in the treatment of genodermatosis
The clinical use of gentamicin always lies in its antimicrobial activity in the past as an aminoglycoside antibiotic. However, in the past decade, there were considerable interests in therapeutic approaches in...
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Article
Long-term exposure to high particulate matter pollution and incident hypertension: a 12-year cohort study in northern China
Numerous cohort studies have reported the association of long-term exposure to particulate matter <10 μm in diameter (PM10) and hypertension in American and European countries. However, these results have been in...
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Article
Open AccessGenomic signatures define three subtypes of EGFR-mutant stage II–III non-small-cell lung cancer with distinct adjuvant therapy outcomes
The ADJUVANT study reported the comparative superiority of adjuvant gefitinib over chemotherapy in disease-free survival of resected EGFR-mutant stage II–IIIA non-small cell lung cancer (NSCLC). However, not all ...
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Article
Open AccessFBXW7 gene polymorphism is associated with type 2 diabetes in the Uygur population in **njiang, China
FBXW7 gene expression is positively correlated with glycolipid metabolism and is associated with diabetes in animal models. In the current study, we focused on exploring whether genetic variants of the FBXW7 g...
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Article
Sleep Characteristics and Cerebrospinal Fluid Progranulin in Older Adults: The CABLE Study
Cerebrospinal fluid (CSF) progranulin (PGRN) is related to various neurodegeneration diseases. And sleep problems can cause abnormality in protein metabolism in vivo. We aim to explore the potential associatio...
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Article
Open AccessBilayer and three dimensional conductive network composed by SnCl2 reduced rGO with CNTs and GO applied in transparent conductive films
Graphene oxide (GO), reduced graphene oxide (rGO) and carbon nanotubes (CNTs) have their own advantages in electrical, optical, thermal and mechanical properties. An effective combination of these materials is...
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Article
c-Src facilitates tumorigenesis by phosphorylating and activating G6PD
Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme in pentose phosphate pathway (PPP), excessive activation of which has been considered to be involved in tumorigenesis. Here, we sh...
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Article
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1
The sympathetic nervous system–catecholamine–uncoupling protein 1 (UCP1) axis plays an essential role in non-shivering adaptive thermogenesis. However, whether there exists a direct effector that physically co...
