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Article
Open AccessMaize ZmLAZ1-3 gene negatively regulates drought tolerance in transgenic Arabidopsis
Molecular mechanisms in response to drought stress are important for the genetic improvement of maize. In our previous study, nine ZmLAZ1 members were identified in the maize genome, but the function of ZmLAZ1 wa...
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Article
Open AccessProtoSimi: label correction for fine-grained visual categorization
Deep models trained by using clean data have achieved tremendous success in fine-grained image classification. Yet, they generally suffer from significant performance degradation when encountering noisy labels...
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Article
Open AccessTGF-β1 and TGF-βR1 variants are associated with clinical outcomes in smoking-related head and neck cancer patients treated with chemoradiation through modulating microRNA-mediated regulation
TGF-β1 and TGF-βR1 play important roles in immune and inflammatory responses. Genetic variants of TGF-β1 rs1800470 and TGF-βR1 rs334348 have emerged as potentially prognostic biomarkers for HPV-related head and n...
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Article
Effect of lesion dimension on survival in patients with T1a renal cell carcinoma who underwent deferred surgery
Small renal masses (SRMs) have been shown to have low malignant potential. Active surveillance (AS), typically characterized by regular follow-up and delayed nephrectomy if necessary, is recommended as an opti...
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Article
Comparison of porous carbon prepared by conventional and microwave-assisted hydrothermal carbonization and its application in supercapacitors
Using Euryale ferox shells as biomass raw material, porous carbon samples were prepared by conventional hydrothermal carbonization and microwave-assisted hydrothermal carbonization followed by KOH activation. Eff...
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Article
Open AccessClinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer
FOXA1 is a pioneer transcription factor that is frequently mutated in prostate, breast, bladder, and salivary gland malignancies. Indeed, metastatic castration-resistant prostate cancer (mCRPC) commonly harbou...
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Article
Branched chemically modified poly(A) tails enhance the translation capacity of mRNA
Although messenger RNA (mRNA) has proved effective as a vaccine, its potential as a general therapeutic modality is limited by its instability and low translation capacity. To increase the duration and level o...
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Article
Open AccessBNST GABAergic neurons modulate wakefulness over sleep and anesthesia
The neural circuits underlying sleep-wakefulness and general anesthesia have not been fully investigated. The GABAergic neurons in the bed nucleus of the stria terminalis (BNST) play a critical role in stress ...
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Article
Open AccessProteomic characterization of hUC-MSC extracellular vesicles and evaluation of its therapeutic potential to treat Alzheimer’s disease
In recent years, human umbilical cord mesenchymal stem cell (hUC-MSC) extracellular vesicles (EVs) have been used as a cell replacement therapy and have been shown to effectively overcome some of the disadvant...
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Article
A Terbium(III)−Organic Framework for High Catalytic Performance on Cycloaddition of CO2 with Epoxides Under Mild Condition
The exquisite combination of [Tb2(CO2)9] units and [Tb2(CO2)6(HCO2)(H2O)2]n chains under acidic solvothermal condition generated a highly robust {(Me2NH2)4[Tb4(DDAC)3(HCO2)(OH2)2]⋅6DMF⋅5H2O}n (SLU-1, H5DDAC = 2,6...
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Article
Open AccessComprehensive Analysis of Cotton Fiber Infrared Maturity Distribution and Its Relation to Fiber HVI and AFIS Properties
Cotton fiber maturity has been reported as average maturity and maturity distribution in a sample, through measuring the fibers in the way of either an individual fiber cross-section or a longitude of several ...
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Article
Precise Cutterhead Clogging Detection for Shield Tunneling Machine Based on Deep Residual Networks
During the construction process of tunnels, the cutterhead of shield tunneling machines may get clogged due to clay adhesion, which may seriously affect the efficiency of the project. Therefore, finding an int...
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Article
The Changing Geography of Scientific Knowledge Production: Evidence from the Metropolitan area Level
The metropolitan areas act as incubators of new knowledge, and play a central role in the process of scientific knowledge production. On the basis of highly cited papers data, this paper adopts spatial sciento...
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Article
Digital twin-driven design for elevator fairings via multi-objective optimization
Traditional geometry optimization of elevator fairings is only based on computational fluid dynamics simulations to find optimal structure parameters, and a large volume of data generated during the elevator o...
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Article
Open AccessCardiologist-level interpretable knowledge-fused deep neural network for automatic arrhythmia diagnosis
Long-term monitoring of Electrocardiogram (ECG) recordings is crucial to diagnose arrhythmias. Clinicians can find it challenging to diagnose arrhythmias, and this is a particular issue in more remote and unde...
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Article
A novel ensemble approach for road traffic carbon emission prediction: a case in Canada
The "Annual Report 2021" from the United Nations Environment Programme (UNEP) highlights that the transportation sector is the fastest-growing greenhouse gas emissions sector, accounting for approximately 25% ...
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Article
Open AccessA Cotyledon-based Virus-Induced Gene Silencing (Cotyledon-VIGS) approach to study specialized metabolism in medicinal plants
Virus-induced gene silencing (VIGS) is widely used in plant functional genomics. However, the efficiency of VIGS in young plantlets varies across plant species. Additionally, VIGS is not optimized for many pla...
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Article
A novel lightweight computerized ECG interpretation approach based on clinical 12-lead data
Although 12-lead electrocardiograms (ECGs) provide a wide range of spatiotemporal characteristics, interpreting them for arrhythmia detection is difficult due to a lack of reliable large-scale clinical dataset...
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Article
Energy Evolution and Coal Crushing Mechanisms Involved in Coal and Gas Outburst
Coal and gas outburst is a dynamic disaster that poses a significant threat to coal mines. Energy analysis is an effective tool for understanding the mechanisms behind such outburst. The energy sources and dis...
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Article
Weighted Heterogeneous Graph-Based Incremental Automatic Disease Diagnosis Method
The objective of this study is to construct a multi-department symptom-based automatic diagnosis model. However, it is difficult to establish a model to classify plenty of diseases and collect thousands of dis...
