2,697 Result(s)
within
**ang-Li Li
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessPrefrontal cortex neurons encode ambient light intensity differentially across regions and layers
While light can affect emotional and cognitive processes of the medial prefrontal cortex (mPFC), no light-encoding was hitherto identified in this region. Here, extracellular recordings in awake mice revealed ...
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Open AccessInter-cell type interactions that control JNK signaling in the Drosophila intestine
JNK signaling is a critical regulator of inflammation and regeneration, but how it is controlled in specific tissue contexts remains unclear. Here we show that, in the Drosophila intestine, the TNF-type ligand, E...
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Open AccessReconfigurable spintronic logic gate utilizing precessional magnetization switching
In traditional von Neumann computing architecture, the efficiency of the system is often hindered by the data transmission bottleneck between the processor and memory. A prevalent approach to mitigate this lim...
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Open AccessComparative optimization of polysaccharide-based nanoformulations for cardiac RNAi therapy
Ionotropic gelation is widely used to fabricate targeting nanoparticles (NPs) with polysaccharides, leveraging their recognition by specific lectins. Despite the fabrication scheme simply involves self-assembl...
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Open AccessAnalysis of factors associated with the development of delayed encephalopathy following acute carbon monoxide poisoning
In this study, we analyzed the factors influencing the development of delayed encephalopathy in patients with acute carbon monoxide poisoning (ACOP) (DEACMP) following conventional treatment such as hyperbaric...
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Open AccessDeep representation learning of chemical-induced transcriptional profile for phenotype-based drug discovery
Artificial intelligence transforms drug discovery, with phenotype-based approaches emerging as a promising alternative to target-based methods, overcoming limitations like lack of well-defined targets. While c...
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Open AccessFirst-line serplulimab plus chemotherapy versus chemotherapy in PD-L1-positive esophageal squamous-cell carcinoma: a cost-effectiveness analysis
Patients with PD-L1-positive esophageal squamous-cell carcinoma (ESCC) were significantly more likely to survive when treated with serplulimab plus cisplatin plus 5-fluorouracil (serplulimab-CF). At this point...
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Open AccessNanoconfinement steers nonradical pathway transition in single atom fenton-like catalysis for improving oxidant utilization
The introduction of single-atom catalysts (SACs) into Fenton-like oxidation promises ultrafast water pollutant elimination, but the limited access to pollutants and oxidant by surface catalytic sites and the i...
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Open AccessCloud inversion analysis of surrounding rock parameters for underground powerhouse based on PSO-BP optimized neural network and web technology
Aiming at the shortcomings of the BP neural network in practical applications, such as easy to fall into local extremum and slow convergence speed, we optimized the initial weights and thresholds of the BP neu...
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Open AccessA chromosome-level genome of the striated frogfish (Antennarius striatus)
The striated frogfish (Antennarius striatus), a member of the sub-order Antennarioidei within the order Lophiiformes, possesses remarkable adaptations. These include the ability to modulate body coloration for ca...
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Open AccessPJA1-mediated suppression of pyroptosis as a driver of docetaxel resistance in nasopharyngeal carcinoma
Chemoresistance is a main reason for treatment failure in patients with nasopharyngeal carcinoma, but the exact regulatory mechanism underlying chemoresistance in nasopharyngeal carcinoma remains to be elucida...
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Open AccessA trait-based root acquisition-defence-decomposition framework in angiosperm tree species
To adapt to the complex belowground environment, plants make trade-offs between root resource acquisition and defence ability. This includes forming partnerships with different types of root associating microo...
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Open AccessLight-evoked deformations in rod photoreceptors, pigment epithelium and subretinal space revealed by prolonged and multilayered optoretinography
Phototransduction involves changes in concentration of ions and other solutes within photoreceptors and in subretinal space, which affect osmotic pressure and the associated water flow. Corresponding expansion...
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Open AccessInhibiting perovskite decomposition by a creeper-inspired strategy enables efficient and stable perovskite solar cells
The commercialization of perovskite solar cells is badly limited by stability, an issue determined mainly by perovskite. Herein, inspired by a natural creeper that can cover the walls through suckers, we adopt...
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Open AccessStructural basis for an early stage of the photosystem II repair cycle in Chlamydomonas reinhardtii
Photosystem II (PSII) catalyzes water oxidation and plastoquinone reduction by utilizing light energy. It is highly susceptible to photodamage under high-light conditions and the damaged PSII needs to be resto...
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Open AccessCholesterol efflux from C1QB-expressing macrophages is associated with resistance to chimeric antigen receptor T cell therapy in primary refractory diffuse large B cell lymphoma
Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated promising efficacy in early trials for relapsed/refractory diffuse large B cell lymphoma (DLBCL). However, its efficacy in treating primary ref...
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Open AccessNavigating the uncertainty: the impact of a student-centered final year project allocation mechanism on student performance
The Final Year Project (FYP) is one of the most important courses for every undergraduate student, and the effective operation of the FYPs in higher education still faces challenges, such as uneven resource di...
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Open AccessProgressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer
Cancer incidence escalates exponentially with advancing age; however, the underlying mechanism remains unclear. In this study, we build a chronological molecular clock at single-cell transcription level with a...
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Open AccessJ-shaped association of the triglyceride glucose-body mass index with new-onset diabetes
The triglyceride glucose-body mass index (TyG-BMI) is a convenient and clinically significant indicator of insulin resistance. This study aims to investigate the correlation between TyG-BMI and the onset of ne...
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Open AccessSingle-molecule reconstruction of eukaryotic factor-dependent transcription termination
Factor-dependent termination uses molecular motors to remodel transcription machineries, but the associated mechanisms, especially in eukaryotes, are poorly understood. Here we use single-molecule fluorescence...
