1,294 Result(s)
within
**an-wen Zhang
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Article
Fibroblast-localized lncRNA CFIRL promotes cardiac fibrosis and dysfunction in dilated cardiomyopathy
CFIRL is a long noncoding RNA (lncRNA), we previously identified as the most significantly upregulated lncRNA in the failing hearts of patients with dilated cardiomyopathy (DCM). In this study, we determined t...
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Open AccessTwo-dimensional materials for future information technology: status and prospects
Over the past 70 years, the semiconductor industry has undergone transformative changes, largely driven by the miniaturization of devices and the integration of innovative structures and materials. Two-dimensi...
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Open AccessSpatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine
Aging and regeneration represent complex biological phenomena that have long captivated the scientific community. To fully comprehend these processes, it is essential to investigate molecular dynamics through ...
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Research on the differential coefficient least-squares optimization method of reverse time migration in acoustic-reflected S-wave imaging logging
The numerical dispersion phenomenon in the finite-difference forward modeling simulations of the wave equation significantly affects the imaging accuracy in acoustic reflection logging. This issue is particula...
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Article
Stepped-up development of accelerator mass spectrometry method for the detection of 60Fe with the HI-13 tandem accelerator
The Moon provides a unique environment for investigating nearby astrophysical events such as supernovae. Lunar samples retain valuable information from these events, via detectable long-lived “fingerprint” rad...
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Open AccessPreoperative chemoradiotherapy in older patients with rectal cancer guided by comprehensive geriatric assessment within a multidisciplinary team—a multicenter phase II trial
The purpose of this study was to evaluate the safety and efficacy of preoperative concurrent chemoradiotherapy (preCRT) for locally advanced rectal cancer in older people who were classified as “fit” by compre...
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Article
Value of orthogonal axial MR images in preoperative T staging of gastric cancer
To assess the value of orthogonal axial images (OAI) of MRI in gastric cancer T staging.
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Open AccessAuthor Correction: Magnetic breakdown and spin-zero effect in quantum oscillations in kagome metal CsV3Sb5
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Article
Observation of spectral lines in the exceptional GRB 221009A
As the brightest gamma-ray burst ever observed, GRB 221009A provided a precious opportunity to explore spectral line features. In this article, we performed a comprehensive spectroscopy analysis of GRB 221009A...
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Article
Open AccessMechanism and deterioration pattern of sandstone surrounding rock voiding at bottom of heavy-haul railway tunnel
This study combines laboratory experiments and discrete element simulation methods to analyze the mechanism and deterioration patterns of sandstone surrounding rock voiding the bottom of a heavy-haul railway t...
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Article
MiR-3074-5p Regulates Trophoblasts Function via EIF2S1/GDF15 Pathway in Recurrent Miscarriage
Dysfunction of extravillous trophoblasts (EVTs) might cause early pregnancy failure by interfering with embryo implantation and/or placentation. We previously reported that the villus miR-3074-5p expression le...
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Article
Four Labdane Diterpenoids from Leonurus japonicus
A new labdane diterpenoid, leojaponotin (1), and three known labdane diterpenoids (2–4), were isolated from Leonurus japonicus. Their structures were elucidated by spectroscopic analysis including NMR and MS.
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Article
Predicting Ki-67 expression in hepatocellular carcinoma: nomogram based on clinical factors and contrast-enhanced ultrasound radiomics signatures
To develop a contrast-enhanced ultrasound (CEUS) clinic-radiomics nomogram for individualized assessment of Ki-67 expression in hepatocellular carcinoma (HCC).
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MRI-based radiomics for prediction of extraprostatic extension of prostate cancer: a systematic review and meta-analysis
We to systematically evaluate the diagnostic performance of MRI radiomics in detecting extracapsular extension (EPE) of prostate cancer (PCa).
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Article
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis
It is well established that the synthesis of extracellular matrix (ECM) in mesangial cells is a major determinant of diabetic kidney disease (DKD). Elucidating the major players in ECM synthesis may be helpful...
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Open AccessMaternal cardiovascular health in early pregnancy and the risk of congenital heart defects in offspring
Congenital heart disease (CHD) is the predominant birth defect. This study aimed to explore the association between maternal cardiovascular health (CVH) and the CHD risk in offspring.
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Open AccessA new TROP2-targeting antibody-drug conjugate shows potent antitumor efficacy in breast and lung cancers
Trophoblast cell surface antigen 2 (Trop2) is considered to be an attractive therapeutic target in cancer treatments. We previously generated a new humanized anti-Trop2 antibody named hIMB1636, and designated ...
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Article
A network analysis of alexithymia and smartphone addiction in children and adults
Research has demonstrated the connection between problematic mobile phone use and alexithymia. However, few study directly compared the pattern of alexithymia’s linkage to smartphone addiction across age group...
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Open AccessApplication of propofol-remifentanil intravenous general anesthesia combined with regional block in pediatric ophthalmic surgery
The aim of this study is to observe the anesthetic effect and safety of intravenous anesthesia without muscle relaxant with propofol-remifentanil combined with regional block under laryngeal mask airway in ped...
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Article
Open AccessIncreased miR-3074-5p expression promotes M1 polarization and pyroptosis of macrophages via ERα/NLRP3 pathway and induces adverse pregnancy outcomes in mice
Decidual macrophages (dMϕs) play critical roles in regulation of immune-microhomeostasis at maternal-fetal interface during pregnancy, but the underlying molecular mechanisms are still unclear. In this study, ...
