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Article
Open AccessTargeting tumor suppressor p53 for organ fibrosis therapy
Fibrosis is a reparative and progressive process characterized by abnormal extracellular matrix deposition, contributing to organ dysfunction in chronic diseases. The tumor suppressor p53 (p53), known for its ...
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Article
Open AccessProtein features fusion using attributed network embedding for predicting protein-protein interaction
Protein-protein interactions (PPIs) hold significant importance in biology, with precise PPI prediction as a pivotal factor in comprehending cellular processes and facilitating drug design. However, experiment...
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Article
Open AccessSpecific convulsions and brain damage in children hospitalized for Omicron BA.5 infection: an observational study using two cohorts
SARS-CoV-2 continues to mutate over time, and reports on children infected with Omicron BA.5 are limited. We aimed to analyze the specific symptoms of Omicron-infected children and to improve patient care.
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Genome editing: An insight into disease resistance, production efficiency, and biomedical applications in livestock
One of the primary concerns for the survival of the human species is the growing demand for food brought on by an increasing global population. New developments in genome-editing technology present promising o...
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Open AccessExploring the causes of the prevalence of vancomycin-resistant Enterococcus faecalis
Bacterial drug resistance represents a significant global concern, with vancomycin-resistant Enterococcus faecalis posing a particularly grave threat to contemporary healthcare systems. This study aims to reveal ...
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Article
Overstory functional groups indicate the legacy of land use in a secondary tropical forest in southwestern China
Anthropogenic disturbances are widespread in tropical forests and influence the species composition in the overstory. However, the impacts of historical disturbance on tropical forest overstory recovery are un...
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Article
Deficiency of FRMD5 results in neurodevelopmental dysfunction and autistic-like behavior in mice
The pathophysiology of autism spectrum disorders (ASDs) is causally linked to postsynaptic scaffolding proteins, as evidenced by numerous large-scale genomic studies [1, 2] and in vitro and in vivo neurobiologica...
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Open AccessAuthor Correction: Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy
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Article
Open AccessYoung osteocyte-derived extracellular vesicles facilitate osteogenesis by transferring tropomyosin-1
Bone marrow mesenchymal stem cells (BMSCs) can undergo inadequate osteogenesis or excessive adipogenesis as they age due to changes in the bone microenvironment, ultimately resulting in decreased bone density ...
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Article
Open AccessA pair of atypical NLR-encoding genes confers Asian soybean rust resistance in soybean
Asian soybean rust (ASR), caused by Phakopsora pachyrhizi, is a devastating disease that is present in all major soybean-producing regions. The limited availability of resistant germplasm has resulted in a scarci...
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Article
Analyzing the surface passivity effect of germanium oxynitride: a comprehensive approach through first principles simulation and interface state density
High-purity germanium (HPGe) detectors, which are used for direct dark matter detection, have the advantages of a low threshold and excellent energy resolution. The surface passivation of HPGe has become cruci...
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Article
Source quantitative identification and control for preferential contaminants in stream sediments from an abandoned lead/zinc mine
Sediment is an important sink for metals within mining environments. This study employs a combination of positive matrix factorization (PMF), random forest (RF) and fuzzy analytic hierarchy process (FAHP) to i...
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Article
Advance in reversible Zn anodes promoted by 2D materials
With the growing energy demand associated with high safety and low-cost requirement, aqueous zinc-ion batteries (AZIBs) have been considered as one of the most promising next-generation batteries. However, som...
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Article
Modulated noble metal/2D MOF heterostructures for improved hydrogen storage of MgH2
The conjugation of external species with two-dimensional (2D) materials has broad application prospects. In this study, we have explored the potential of noble metal/2D MOF heterostructures in hydrogen storage...
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Retraction Note: Sector-like optimization model of 5G base transceiver stations redeployment and the generalization
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Open AccessLactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model
Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate ...
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Article
Open AccessPMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness
Host survival depends on the elimination of virus and mitigation of tissue damage. Herein, we report the modulation of D-mannose flux rewires the virus-triggered immunometabolic response cascade and reduces ti...
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CircHAT1 regulates the proliferation and phenotype switch of vascular smooth muscle cells in lower extremity arteriosclerosis obliterans through targeting SFRS1
This study aimed to decipher the mechanism of circular ribonucleic acids (circRNAs) in lower extremity arteriosclerosis obliterans (LEASO). First, bioinformatics analysis was performed for screening significan...
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Open AccessCorrection to: Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children
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Open AccessHsa_circ_0005397 promotes hepatocellular carcinoma progression through EIF4A3
The purpose of this study was to explore the expression and potential mechanism of hsa_circ_0005397 in hepatocellular carcinoma progression.
