1,388 Result(s)
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Article
Identification and characterization of the gene causing type 1 spinocerebellar ataxia
Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disorder caused by expansion of a CAG trinucleotide repeat. In this study, we describe the identification and characterization of the gene harbouring...
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Article
Antidiuretic hormone levels and polyuria in spinal cord injury. A preliminary report
Chronic cervical spinal cord injury is characterized by defects in sodium and water homeostasis and defects of adaptive hormonal responses. The plasma osmolality is maintained in a relatively narrow range, the...
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Article
Compliance and complications of clean intermittent catheterization in the spinal cord injured patient
The optimal management of the neuropathic bladder secondary to spinal cord injury remains unsettled. Some have advocated the use of chronic indwelling catheters in tetraplegic patients supposedly due to compar...
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Article
Establishment of a new human extrahepatic bile duct carcinoma cell line (OCUCh-LM1) and experimental liver metastatic model
A new human extrahepatic bile duct carcinoma cell line, designated OCUCh-LM1, was established from a liver metastatic lesion in a 61-year-old male. OCUCh-LM1 cells proliferated in a monolayered sheet with a po...
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Article
A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth
Expression of the RIα subunit of cAMP-dependent protein kinase type I is enhanced in human cancer cell lines, in primary tumours, in cells after transformation and in cells upon stimulation of growth. We have inv...
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Article
Microvessel quantitation in invasive breast cancer by staining for factor VIII-related antigen
The clinical importance of microvessel quantitation as a prognostic indicator in invasive breast cancer was examined. This study included 155 patients with invasive breast cancer, with a median follow-up of 82...
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Tumour angiogenesis and tumour cell proliferation as prognostic indicators in gastric carcinoma
Tumour growth depends on neovascularisation and tumour cell proliferation. Factor VIII-related antigen (F-VIII RA) localises to vascular endothelium. Expression of proliferating cell nuclear antigen (PCNA) is ...
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Article
Establishment of two new scirrhous gastric cancer cell lines: analysis of factors associated with disseminated metastasis
Determination of the differences between cell lines which are derived from a primary tumour and a disseminated metastatic lesion from the same patient may aid in elucidating the factors associated with dissemi...
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Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice
We established a peritoneal-metastatic model for scirrhous gastric carcinoma. Peritoneal metastasis had developed after intraperitoneal inoculation of OCUM-2MD3 cells in nude mice. This cell line was derived f...
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Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma
It is known that angiogenesis plays an important role in the growth and metastasis of solid tumours. Several angiogenic factors have been identified and platelet-derived endothelial cell growth factor (PD-ECGF...
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Article
Interactions of SCBA with bioscientists in Asia
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Article
Open AccessHigh-does nitric oxide induces apoptosis in HL-60 human myeloid leukemia cells
The treatment of human promyeloid leukemia cell line HL-60 cells with nitric oxide (NO) is associated with loss of proliferative apacity and induction of monocytic differentiation. The present results demonstr...
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Article
A novel spice–site mutation in the γ subunit of the epithelial sodium channel gene in three pseudohypoaldosteronism type 1 families
Pseudohypoaldosteronism type 1 (PHA1, OMIM 264350) is an uncommon inherited disorder characterized by salt-wasting and end-organ unrespon-siveness to mineralocorticoids1. A complete genome search using homozygosi...
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Clinical significance of serum CYFRA 21-1 in gastric cancer
We studied the clinical significance of the soluble cytokeratin 19 fragment detected with monoclonal antibody CYFRA 21-1 in the sera of patients with histologically proven gastric cancer. Sera of 110 patients ...
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Article
Endothelin-1 and insulin induce cellular inactivation of protein kinase FA/glycogen synthase kinase-3α in a common signaling pathway
In this study, we investigate the effects of endothelin-1 (ET-1) and insulin on the cellular activity of protein kinase FA/glycogen synthase kinase-3α (kinase FA/GSK-3α) in rat adipocytes. The cellular activity o...
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Bradykinin–evoked sensitization of airway sensory nerves: A mechanism for ACE–inhibitor cough
Cough accompanied by an increased sensitivity of the cough reflex is the most common symptom of inflammatory airway disease1,5. This symptom is also frequently reported in patients receiving angiotensin–convertin...
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Article
Open AccessCircumvention of drug resistance in cancer cells by a new fluoropyrimidine analogue
The potentiation of antitumor drugs by their analogues is one of strategies for overcoming cellular resistance to chemotherapy. In attempts to improve the efficacy of 5-fluorouracil (5-FU) and overcome 5-FU re...
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Differential responses of scirrhous and well-differentiated gastric cancer cells to orthotopic fibroblasts
Scirrhous gastric cancer cells proliferate rapidly with fibrosis, when the cancer cells invade into the submucosa of the stomach. To investigate the mechanisms responsible for the rapid proliferation, the grow...
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Article
Role of alpha 2 beta 1- and alpha 3 beta 1-integrin in the peritoneal implantation of scirrhous gastric carcinoma
We established a highly peritoneal-seeding cell line, OCUM-2MD3, from a poorly peritoneal-seeding cell line, OCUM-2M, of human scirrhous gastric carcinoma. The intraperitoneal inoculation of OCUM-2MD3 cells pr...
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Sequential activation and production of matrix metalloproteinase-2 during breast cancer progression
The proteolytic processes are thought to be the critical point in tumor invasion and metastasis, mainly by matrix metalloproteinases (MMPs) and serine proteases. We measured the activity of MMP-2 from 28 norma...
