368 Result(s)

Article

XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

Qiu-Zhong Pan, **g-**g Zhao, Liang Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Asian Pacific Association for the Study of the Liver clinical practice guidelines on liver transplantation

Liver transplantation is a highly complex and challenging field of clinical practice. Although it was originally developed in western countries, it has been further advanced in Asian countries through the use ...

Dong-Sik Kim, Young-In Yoon, Beom Kyung Kim, Ashok Choudhury… in Hepatology International (2024)

Article

Evaluation of risk stratification for acute kidney injury: a comparative analysis of EKFC, 2009 and 2021 CKD-EPI glomerular filtration estimating equations

The adoption of the 2021 CKD-EPIcr equation for glomerular filtration rate (GFR) estimation provided a race-free eGFR calculation. However, the discriminative performance for AKI risk has been rarely validated...

Jeong Min Cho, Jung Hun Koh, Minsang Kim, Sehyun Jung, Semin Cho… in Journal of Nephrology (2024)

Article

Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses

The Orthopoxvirus genus, especially variola virus (VARV), monkeypox virus (MPXV), remains a significant public health threat worldwide. The development of therapeutic antibodies against orthopoxviruses is largely...

Hang Chi, Suo-Qun Zhao, Ru-Yi Chen… in Signal Transduction and Targeted Therapy (2024)

Article

Long-term ozone exposure and mortality in patients with chronic kidney disease: a large cohort study

Epidemiologic studies on the effects of long-term exposure to ozone (O₃) have shown inconclusive results. It is unclear whether to O₃ has an effect on chronic kidney disease (CKD). We investigated the effects of ...

E** Kim, Hyuk Huh, Yongwon Mo, Jae Yoon Park, Jiyun Jung, Hajeong Lee… in BMC Nephrology (2024)

Article

Mid- and long-term risk of atrial fibrillation among breast cancer surgery survivors

The risk of incident atrial fibrillation (AF) among breast cancer survivors, especially for younger women, and cancer treatment effects on the association remain unclear. This study aimed to investigate the ri...

Yong-Moon Mark Park, Wonyoung Jung, Yohwan Yeo, Sang Hyun Park… in BMC Medicine (2024)

Article

Identification macrophage signatures in prostate cancer by single-cell sequencing and machine learning

The tumor microenvironment (TME) encompasses a variety of cells that influence immune responses and tumor growth, with tumor-associated macrophages (TAM) being a crucial component of the TME. TAM can guide pro...

Zhen Kang, Yu-Xuan Zhao, Ren Shun Qian Qiu… in Cancer Immunology, Immunotherapy (2024)

Article

Higher sclerostin is associated with pulmonary hypertension in pre-dialysis end-stage kidney disease patients: a cross-sectional prospective observational cohort study

Pulmonary hypertension (PH) is a complication of chronic kidney disease (CKD) that contributes to mortality. Sclerostin, a SOST gene product that reduces osteoblastic bone formation by inhibiting Wnt/β-catenin...

Jonghyun Lee, Dong-Hyuk Cho, Hyeon-** Min, Young-Bin Son… in BMC Pulmonary Medicine (2024)

Article

Characteristics and standards of severe sagittal imbalance in adult patients with spinal deformities: a retrospective analysis

To analyze the characteristics of “severe” dynamic sagittal imbalance (DSI) in patients with adult spinal deformity (ASD) and establish criteria for them.

Yong-Chan Kim, Kee-Yong Ha, Sung-Min Kim, **ongjie Li… in BMC Musculoskeletal Disorders (2024)

Article

Association of antenatal corticosteroids with mortality and morbidities in very preterm infants born to women with hypertensive disorders of pregnancy: a multicenter prospective cohort study

Hypertensive disorders of pregnancy (HDP) is the most common cause of indicated preterm delivery, but the impact of prenatal steroid exposure on the outcomes of preterm infants born to HDP mothers, who may be ...

**ao-Yu Dong, Jian-Hong Qi, Qing-Cui Zhuo, Yan-Jie Ding… in BMC Pregnancy and Childbirth (2024)

Article

Clinical characteristics and prognosis of non-APAP drug-induced acute liver failure: a large multicenter cohort study

There is growing recognition of natural history, complications, and outcomes of patients who develop non-acetaminophen (APAP) drug-induced acute liver failure (ALF). To clarify high-risk factors and develop a ...

Lin Han, Ang Huang, **jun Chen, Guangju Teng, Ying Sun… in Hepatology International (2024)

Article

Impacts of Adaptive Statistical Iterative Reconstruction-V and Deep Learning Image Reconstruction Algorithms on Robustness of CT Radiomics Features: Opportunity for Minimizing Radiomics Variability Among Scans of Different Dose Levels

This study aims to investigate the influence of adaptive statistical iterative reconstruction-V (ASIR-V) and deep learning image reconstruction (DLIR) on CT radiomics feature robustness. A standardized phantom...

**gyu Zhong, Zhiyuan Wu, Lingyun Wang… in Journal of Imaging Informatics in Medicine (2024)

Article

Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor)

A lasting imbalance between fatty acid synthesis and consumption leads to non-alcoholic fatty liver disease (NAFLD), coupled with hepatitis and insulin resistance. Yet the details of the underlying mechanisms ...

Lei Zhang, Jiabing Chen, **aoying Yang… in Signal Transduction and Targeted Therapy (2024)

Article

Validation of Roussouly classification in predicting the occurrence of adjacent segment disease after short-level lumbar fusion surgery

Recent studies demonstrated that restoring sagittal alignment to the original Roussouly type can remarkably reduce complication rates after adult spinal deformity surgery. However, there is still no data provi...

Muyi Wang, **n Wang, Hao Wang, Yifei Shen… in Journal of Orthopaedics and Traumatology (2024)

Article

NUDT21 interacts with NDUFS2 to activate the PI3K/AKT pathway and promotes pancreatic cancer pathogenesis

NUDT21 (Nudix Hydrolase 21) has been shown to play an essential role in multiple biological processes. Pancreatic adenocarcinoma (PAAD) is one of the most fatal cancers in the world. However, the biological fu...

**ao-Dong Huang, Yong-Wei Chen, Lv Tian… in Journal of Cancer Research and Clinical On… (2024)

Article

Variety of femoral anteversion and its measurement in cementless total hip arthroplasty: Does robotic technology improve accuracy?

High-performance total hip arthroplasty (THA) depends on the accurate position of components. However, femoral anteversion is variable, and current studies only used traditional instruments to evaluate it, suc...

Hongyi Shao, Yong Huang, De** Yang… in Journal of Orthopaedic Surgery and Research (2024)

Article

Efficacy of Qingpeng ointment (a Tibetan medicine) for acute gouty arthritis: a multi-center, randomized, double-blind, placebo-controlled trial

This study aims to assess the efficacy and safety of Qingpeng ointment (QPO), a Tibetan medicine for alleviating symptoms in individuals with acute gouty arthritis (AGA).

Ya-xi Shang, Shu-feng Wei, Ke-peng Yang… in BMC Complementary Medicine and Therapies (2024)

Article

Comparison between the mesenteric fixation method (MEFIX) and conventional methods at preventing the occurrence of Petersen’s hernia: a study protocol for a multicenter randomized controlled trial

Petersen’s hernia, which occurs after Billroth-II (B-II) or Roux-en-Y (REY) anastomosis, can be reduced by defect closure. This study aims to compare the incidence of bowel obstruction above Clavien–Dindo clas...

Jae Kyun Park, Dae Hwan Kim, Tae-Yong Jeon, Sang-Ho Jeong, Tae Han Kim… in Trials (2024)

Article

Current Mycoplasma pneumoniae epidemic among children in Shanghai: unusual pneumonia caused by usual pathogen

**ao-Bo Zhang, Wen He, Yong-Hao Gui, Quan Lu, Yong Yin… in World Journal of Pediatrics (2024)

Article

Association of TNF-α, IGF-1, and IGFBP-1 levels with the severity of osteopenia in mice with nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) exhibits a close association with osteoporosis. This work aims to assess the potential effects of NAFLD on the progression of osteopenia in animal models.

Tong-Hao Wang, Jian-Biao Li, Yong-Gang Tian… in Journal of Orthopaedic Surgery and Research (2023)