71 Result(s)
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Article
Hao-**n Niu
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PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours
The protein arginine methyltransferase 5 (PRMT5), which is highly expressed in tumour tissues, plays a crucial role in cancer development. However, the mechanism by which PRMT5 promotes cancer growth is poorly...
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Open AccessAmelioration of radiation-induced liver damage by p-coumaric acid in mice
Radiation-induced liver damage (RILD) is a spiny problem in radiotherapy or other circumstances that exposure to radiation. The need for radioprotective agent is increasing to protect liver tissue. This study ...
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An optimized numerical method to pre-researching the performance of solid-phase oxygen control in a non-isothermal lead–bismuth eutectic loop
In the present work, a new transient calculation method for parameters that can be used to evaluate the ability of oxygen control in a non-isothermal lead–bismuth eutectic (LBE) loop with solid-phase oxygen co...
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A Furan-based Phosphaphenanthrene-containing Derivative as a Highly Efficient Flame-retardant Agent for Epoxy Thermosets without Deteriorating Thermomechanical Performances
In order to reduce greenhouse gas emissions, develo** flame retardants from bio-based resources has aroused extensive interest in recent years. In this work, we utilized furfural (biomass) and 9,10-dihydro-9...
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The construction of double type II heterostructure from CdS and Ni-MOF-74 with two structures and enhanced mechanism of photocatalytic water splitting
Visible light-driven hydrogen production by water splitting has attracted much attention because of its advantages of low cost, relative safety, and environmental friendliness. In this paper, a series of Ni-MO...
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Experimental study of non-uniform bubbles in a plume
The bubble plume is an important flow phenomenon, ubiquitous in many fields. The non-uniform bubbles in a plume are often simply considered as uniform and moving with a same slip velocity in an integral model....
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Open AccessSignificance of Macrophage Subtypes in the Peripheral Blood of Children with Systemic Juvenile Idiopathic Arthritis
Symptomatic juvenile idiopathic arthritis (sJIA) is an autoinflammatory disease, and monocytes/macrophages play an important role. However, which macrophage subtype plays a major role in different stages of sJ...
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A Pole Pair Segment of Oil-cooling Air-Core Stator for a 2 MW Direct-Drive High Temperature Superconducting Wind Power Generator
A 2 MW direct-drive (DD) high temperature superconducting (HTS) wind power generator with HTS wires in the rotor field windings and copper transposed conductor in the stator coils was explored for the wind tur...
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Open AccessScutellarin ameliorates neonatal hypoxic-ischemic encephalopathy associated with GAP43-dependent signaling pathway
Neonatal hypoxic-ischemic encephalopathy (HIE) refers to the perinatal asphyxia caused by the cerebral hypoxic-ischemic injury. The current study was aimed at investigating the therapeutic efficacy of Scutella...
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Crustal deformation and dynamics of Early Cretaceous in the North China Craton
The Early Cretaceous represents a peak period of the North China Craton (NCC) destruction. A comprehensive analysis of crustal deformation during this period can reveal processes and dynamics of the destructio...
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Novel assisted cough system based on simulating cough airflow dynamics
Cough is a defensive behavior that protects the respiratory system from infection and clears airway secretions. Cough airflow dynamics have been analyzed by a variety of mathematical and experimental tools. In...
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Combined therapy of intensive statin plus intravenous rt-PA in acute ischemic stroke: the INSPIRE randomized clinical trial
To investigate the safety and efficacy of intensive statin in the acute phase of ischemic stroke after intravenous thrombolysis therapy.
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Open AccessSevere fever with thrombocytopenia syndrome with re-infection in China: a case report
Severe fever with thrombocytopenia syndrome (SFTS), an emerging tickborne infectious disease caused by a novel banyangvirus (SFTS virus, SFTSV), was endemic in several Asian countries with a high mortality up ...
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Open AccessWolfberry genomes and the evolution of Lycium (Solanaceae)
Wolfberry Lycium, an economically important genus of the Solanaceae family, contains approximately 80 species and shows a fragmented distribution pattern among the Northern and Southern Hemispheres. Although seve...
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Open AccessSerum lnc34a is a potential prediction biomarker for bone metastasis in hepatocellular carcinoma patients
Early screening and intervention therapies are crucial to improve the prognosis of hepatocellular carcinoma (HCC) patients with bone metastasis. We aimed to identify serum lncRNA as a prediction biomarker in H...
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Back-n white neutron source at CSNS and its applications
Back-streaming neutrons from the spallation target of the China Spallation Neutron Source (CSNS) that emit through the incoming proton channel were exploited to build a white neutron beam facility (the so-call...
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Open AccessPredicting the present-day in situ stress distribution within the Yanchang Formation Chang 7 shale oil reservoir of Ordos Basin, central China
The Yanchang Formation Chang 7 oil-bearing layer of the Ordos Basin is important in China for producing shale oil. The present-day in situ stress state is of practical implications for the exploration and deve...
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S100A14 suppresses metastasis of nasopharyngeal carcinoma by inhibition of NF-kB signaling through degradation of IRAK1
Nasopharyngeal carcinoma (NPC) is a unique head and neck cancer with highly aggressive and metastatic potential in which distant metastasis is the main reason for treatment failure. Till present, the underlyin...
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Open AccessEZH2-inhibitor DZNep enhances apoptosis of renal tubular epithelial cells in presence and absence of cisplatin
The enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and induces the trimethylation of histone H3 lysine 27 (H3K27me3) in the promoter of many key genes; EZH2 acts as a transcriptional repress...
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Surface Patterns of a Tetrahedral Polyelectrolyte Brush Induced by Grafting Density and Charge Fraction
A tetrahedral polyelectrolyte brush in the presence of trivalent counterions is researched under the condition of good solution by means of molecular dynamics simulations. Grafting density and charge fraction ...
