201 Result(s)
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Open AccessOcular biometrics in eyes with different white-to-white corneal diameter in young myopic adults
The interactions between white-to-white corneal diameter (WTW) and other ocular biometrics are important for planning of refractive surgery and understanding of ocular structural changes in myopia, but such in...
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Open AccessCell softness renders cytotoxic T lymphocytes and T leukemic cells resistant to perforin-mediated killing
Mechanical force contributes to perforin pore formation at immune synapses, thus facilitating the cytotoxic T lymphocytes (CTL)-mediated killing of tumor cells in a unidirectional fashion. How such mechanical ...
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Open AccessInterfacial magnetic spin Hall effect in van der Waals Fe3GeTe2/MoTe2 heterostructure
The spin Hall effect (SHE) allows efficient generation of spin polarization or spin current through charge current and plays a crucial role in the development of spintronics. While SHE typically occurs in non-...
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Open AccessIdentification of a lipid homeostasis-related gene signature for predicting prognosis, immunity, and chemotherapeutic effect in patients with gastric cancer
Gastric cancer (GC) is one of the most common and deadliest cancers worldwide. Lipid homeostasis is essential for tumour development because lipid metabolism is one of the most important metabolic reprogrammin...
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Open AccessChromosome-level genome assembly and annotation of eel goby (Odontamblyopus rebecca)
The eel gobies fascinate researchers with many important features, including its unique body structure, benthic lifestyle, and degenerated eyes. However, genome assembly and exploration of the unique genomic c...
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Open AccessUpcycling poly(succinates) with amines to N-substituted succinimides over succinimide anion-based ionic liquids
The chemical transformation of waste polymers into value-added chemicals is of significance for circular economy and sustainable development. Herein, we report upcycling poly(succinates) (PSS) with amines into...
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Open AccessIdentification of shared pathogenetic mechanisms between COVID-19 and IC through bioinformatics and system biology
COVID-19 increased global mortality in 2019. Cystitis became a contributing factor in SARS-CoV-2 and COVID-19 complications. The complex molecular links between cystitis and COVID-19 are unclear. This study in...
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Open AccessApproaching expert-level accuracy for differentiating ACL tear types on MRI with deep learning
Treatment for anterior cruciate ligament (ACL) tears depends on the condition of the ligament. We aimed to identify different tear statuses from preoperative MRI using deep learning-based radiomics with sex an...
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Open AccessMyeloid cells interact with a subset of thyrocytes to promote their migration and follicle formation through NF-κB
The pathogenesis of thyroid dysgenesis (TD) is not well understood. Here, using a combination of single-cell RNA and spatial transcriptome sequencing, we identify a subgroup of NF-κB-activated thyrocytes locat...
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Open AccessJoint liability and aggravation? An inspection of legislative and judicial practices in cases of the crime of the abduction, sale, and purchase of women and children in China
Human trafficking is a harmful, widespread and pressing issue that demands attention. However, the prevalence of such crimes may vary across different countries and time periods, which means that there may not...
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Open AccessDNA damage repair-related gene signature for identifying the immune status and predicting the prognosis of hepatocellular carcinoma
The heterogeneity of hepatocellular carcinoma (HCC) poses a challenge for accurate prognosis prediction. DNA damage repair genes (DDRGs) have an impact on a wide range of malignancies. However, the relevance o...
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Open AccessNeoadjuvant camrelizumab plus nab-paclitaxel and epirubicin in early triple-negative breast cancer: a single-arm phase II trial
Immunotherapy combined with chemotherapy has been demonstrated to be effective in early triple-negative breast cancer (TNBC). In this single-arm, phase II study with Simon’s two-stage design, we investigated t...
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Open AccessA high-quality chromosome-level wild rice genome of Oryza coarctata
Oryza coarctata (2n = 4X = 48, KKLL) is an allotetraploid, undomesticated relative of rice and the only species in the genus Oryza with tolerance to high salinity and submergence. Therefore, it contains important...
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Open AccessIn situ electron paramagnetic resonance spectroscopy using single nanodiamond sensors
An ultimate goal of electron paramagnetic resonance (EPR) spectroscopy is to analyze molecular dynamics in place where it occurs, such as in a living cell. The nanodiamond (ND) hosting nitrogen-vacancy (NV) ce...
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Open AccessA dynamic multi-objective optimization method based on classification strategies
The dynamic multi-objective optimization problem is a common problem in real life, which is characterized by conflicting objectives, the Pareto frontier (PF) and Pareto solution set (PS) will follow the changi...
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Open AccessComparison of miRNA transcriptome of exosomes in three categories of somatic cells with derived iPSCs
Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) through epigenetic manipulation. While the essential role of miRNA in reprogramming and maintaining pluripotency is well studied, l...
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Open AccessDirectly imaging excited state-resolved transient structures of water induced by valence and inner-shell ionisation
Real-time imaging of transient structure of the electronic excited state is fundamentally critical to understand and control ultrafast molecular dynamics. The ejection of electrons from the inner-shell and val...
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Open AccessO-methyltransferase-like enzyme catalyzed diazo installation in polyketide biosynthesis
Diazo compounds are rare natural products possessing various biological activities. Kinamycin and lomaiviticin, two diazo natural products featured by the diazobenzofluorene core, exhibit exceptional potency a...
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Open AccessLigand recognition and G protein coupling of the human itch receptor MRGPRX1
MRGPRX1, a Mas-related GPCR (MRGPR), is a key receptor for itch perception and targeting MRGPRX1 may have potential to treat both chronic itch and pain. Here we report cryo-EM structures of the MRGPRX1-Gi1 and...
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Open AccessGeospatial map** of distribution grid with machine learning and publicly-accessible multi-modal data
Detailed and location-aware distribution grid information is a prerequisite for various power system applications such as renewable energy integration, wildfire risk assessment, and infrastructure planning. Ho...