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Characterisation of the molecular responses to xenoestrogens using gene expression profiling
The two estrogen receptors (ERs), ERαand ERβ, are molecular targets of the xenoestrogen class of endocrine disruptors. These receptors are ligand-activated transcription factors regulated by naturally occurrin...
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Glucosinolates in the human diet. Bioavailability and implications for health
The glucosinolates are a large group of sulphur-containing glucosides found in brassica vegetables. After physical damage to the plant tissue, glucosinolates are broken down, by the endogenous enzyme myrosinas...
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Preface Dietary phytochemicals and human health
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Workshop on European research on phytochemicals – International Symposium on: Dietary Phytochemicals and Human Health. Salamanca (Spain), April 18–20, 2002
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Folate bioavailability and health
Since its discovery in 1931 by Lucy Wills, and its first isolation in 1941 by Mitchell, Snell and Williams, our understanding of the fascinating world of folic acid and one-carbon metabolism, and its role in h...
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Antioxidants; not the only reason to eat fruit and vegetables
There is a considerable body of evidence, from epidemiology, that fruits and vegetables help to prevent cancer. This is commonly attributed to the antioxidants that they contain, which are supposed to decrease...
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Biologically active polysaccharides as possible lead compounds
Various carbohydrate polymers have during the last decades been shown to be responsible for biological effects, either by exhibiting the effect themselves or by inducing effects via complex reaction cascades. ...
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Investigation of some bioactive Thai medicinal plants
It has been estimated that plants are the most important source of medicine for more than 80% of the world’s population. Medicinal plants are a vital source of medication in develo** countries. Despite the w...
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Analytical tools for the detection and characterization of biologically active compounds from nature
Nature has been recognized as a rich source of medicinal compounds for hundreds to thousands of years. Today, a vast range of drugs, which represent the cornerstones of modern pharmaceutical care, are either n...
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Secondary metabolites from Argania spinosa (L.) Skeels
Argania spinosa (L.) Skeels is a tree that plays a crucial role in the rural and urban economy of Morocco. Not only is the tree used in traditional medicine but its fruits contain almonds used to...
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Isoprenoid flavonoids are new leads in the modulation of chemoresistance
Flavonoid compounds are able to bind to P-glycoprotein (P-gp), a transporter involved in chemoresistance of cancer cells. This interaction involves, at least in part, two overlap** sites in the cytosolic dom...
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Sarcomelicope alkaloids as leads for the discovery of new antitumor acronycine derivatives
The acridone alkaloid acronycine first isolated from Acronychia baueri Schott (Rutaceae) in 1948, was later shown to exhibit a promising activity against a broad spectrum of solid tumors. ...
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Novel phenylanthraquinones, isofuranonaphthoquinones, homoisoflavonoids, and biflavonoids from African plants in the genera Bulbine, Scilla, Ledebouria, and Rhus
The sale of non-cultivated plants poses a real threat to the survival of a large number of plant species. On the other hand, the fact that a given plant has become a traded item is an important lead in the eff...
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Bioactive compounds from some Kenyan ethnomedicinal plants: Myrsinaceae, Polygonaceae and Psiadia punctulata
There are several described medicinal plants in Kenya from a flora of approximately 10,000 members. Strong cross-medical information from the 42 ethnic groups points to the high potential of some of these spec...
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Natural products in drug discovery – Creating a new vision
“If only they had chosen to develop natural product drugs in a sustainable manner at the turn of the century”. In 2050, when the Earth has a population of at least 9 billion, will this be our legacy as the wor...
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Isatis tinctoria – From the rediscovery of an ancient medicinal plant towards a novel anti-inflammatory phytopharmaceutical
An account on the reinvestigation of the old dye and medicinal plant Isatis tinctoria as an anti-inflammatory and current research on the active principles in woad is given. In a broad-based screening, a dichloro...
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High performance separation technologies and spectroscopic tools for plant extract characterization in phytomics
The review is concerned with fast analytical methods for the qualitative and quantitative determination of plant constituents and phytopharmaceutical products. Emphasis is put on the determination of leading c...
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Twenty years of research into medicinal plants: Results and perspectives
Over the years 1981 to 2001 there has been a rapid evolution of research into medicinal plants. The major improvement has been the introduction of simple and predictive bioassays for bioactivity-guided isolati...
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Are acylphloroglucinols lead structures for the treatment of degenerative diseases?
In recent years a widespread interest in the antidepressant activity of Hypericum perforatum L. has attracted much activity in investigating metabolites from the Guttiferae, many of which are biologically active ...
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Investigation of biologically active natural products using online LC-bioassay, LC-NMR, and LC-MS techniques
