61 Result(s)
within
Animal Genetics and Genomics
Biomedicine, general
Neurosciences
**u Tao
Article
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Article
Growth and folding of the mammalian cerebral cortex: from molecules to malformations
An important feature of cerebral cortex development is the increase in the thickness and folding of surface areas in many species.
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Scaling down of balanced excitation and inhibition by active behavioral states in auditory cortex
The authors report that in mouse auditory cortex, the sensory-evoked spike responses of layer 2/3 (L2/3) excitatory cells were scaled down with preserved sensory tuning when animals transitioned from quiescenc...
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Visualizing an emotional valence map in the limbic forebrain by TAI-FISH
This study describes the segregated neural representations at single cell level and in whole brain when mice are presented with positive and negative emotional stimuli given in succession. Using a newly develo...
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Developmental regulation of human cortex transcription and its clinical relevance at single base resolution
Brain transcriptomics is limited by existing annotations of expressed gene products. Here the authors identify differentially expressed regions of the genome across development and aging in the human brain. Th...
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Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity
The authors discovered that circular RNAs are significantly enriched in the mouse brain and can be visualized in situ, near synapses. They observed that many circRNAs change their abundance during synaptogenesis ...
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Map** DNA methylation across development, genotype and schizophrenia in the human frontal cortex
DNA methylation in human brain shows dramatic variation across development. Genetic loci implicated in risk for schizophrenia are enriched for epigenetic states that show changes from the transition from prena...
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Dynamic regulation of RNA editing in human brain development and disease
RNA sequences are generally considered to be a mirror of DNA sequences. However, that dogma has become challenged as RNA editing is increasingly recognized. This study explored the global landscape of RNA edit...
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Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation
Relatively little is known about the mechanisms that preserve memories during long-term storage. The authors found that neural activation during learning triggers long-lasting transcription of a specific neure...
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Direction selectivity starts early
Disruption of retinal direction selectivity reveals both peripheral and central computations contributing to direction selectivity in mouse visual cortex. These mechanisms work together to better encode motion...
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Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
Genome-wide association studies have identified 108 schizophrenia risk loci, but biological mechanisms for individual loci are largely unknown. Using developmental, genetic and illness-based RNA sequencing exp...
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Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease
Enhancers function as DNA logic gates and may control specialized functions of billions of neurons. Here we show a tailored program of noncoding genome elements active in situ in physiologically distinct dopam...
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Publisher Correction: Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease
In the version of this article initially published, the legends for Supplementary Figs. 4–8 and 10–14 contained errors. The Supplementary Figure legends have been corrected in the HTML and PDF versions of the ...
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Article
Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1–SOX2 positive-feedback loop
Early invasive growth along specific anatomical structures, especially the white matter tract, is regarded as one of the main causes of poor therapeutic outcome of people with gliomas. We show that some glioma...
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Author Correction: Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1–SOX2 positive-feedback loop
The original and corrected figures are shown in the accompanying Author Correction.
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A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data
Genome-wide association studies (GWAS) have identified more than 100 schizophrenia (SCZ)-associated loci, but using these findings to illuminate disease biology remains a challenge. Here we present integrative...
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L3MBTL1 regulates ALS/FTD-associated proteotoxicity and quality control
Misfolded protein toxicity and failure of protein quality control underlie neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal dementia. Here, we identified Lethal(3)malignant...
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A novel cortico-intrathalamic circuit for flight behavior
Flight, an active fear response to imminent threat, is dependent on the rapid risk assessment of sensory information processed by the cortex. The thalamic reticular nucleus (TRN) filters information between th...
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Publisher Correction: L3MBTL1 regulates ALS/FTD-associated proteotoxicity and quality control
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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A neural circuit for comorbid depressive symptoms in chronic pain
Comorbid depressive symptoms (CDS) in chronic pain are a common health problem, but the neural circuit mechanisms underlying these symptoms remain unclear. Here we identify a novel pathway involving 5-hydroxyt...
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Publisher Correction: A neural circuit for comorbid depressive symptoms in chronic pain
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
