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Article
Science, Humanities and Social Sciences, multidisciplinary
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Article
PAA-capped GdF3 nanoplates as dual-mode MRI and CT contrast agents
Aiming at improving the sensitivity and accuracy of diagnosis, the combination of magnetic resonance imaging (MRI) and X-ray computed tomography (CT) in a single probe is in urgent need. Here, we report the de...
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Open Access3, 4-dihydroxyl-phenyl lactic acid restores NADH dehydrogenase 1 α subunit 10 to ameliorate cardiac reperfusion injury
The present study aimed to detect the role of 3, 4-dihydroxyl-phenyl lactic acid (DLA) during ischemia/reperfusion (I/R) induced myocardial injury with emphasis on the underlying mechanism of DLA antioxidant. ...
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Open AccessSCARECROW-LIKE15 interacts with HISTONE DEACETYLASE19 and is essential for repressing the seed maturation programme
Epigenetic regulation of gene expression is critical for controlling embryonic properties during the embryo-to-seedling phase transition. Here we report that a HISTONE DEACETYLASE19 (HDA19)-associated regulato...
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Open AccessGenetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone
The genome sequences of 175 Ebola virus from five districts in Sierra Leone, collected during September–November 2014, show that the rate of virus evolution seems to be similar to that observed during previous...
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Open AccessHighlighting Indication of extracorporeal membrane oxygenation in endocrine emergencies
Extracorporeal membrane oxygenation (ECMO) has been repeatedly used to rescue patients with cardiopulmonary arrest. However, its clinical utility in endocrine emergencies remains unclear. Herein, we describe a...
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Open AccessInsight into Evolution, Processing and Performance of Multi-length-scale Structures in Planar Heterojunction Perovskite Solar Cells
The structural characterization correlated to the processing control of hierarchical structure of planar heterojunction perovskite layer is still incomplete due to the limitations of conventional microscopy an...
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Erratum: Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone
Nature 524, 93–96 (2015); doi:10.1038/nature14490 This Letter should have contained an associated Creative Commons statement in the Author Information section. In addition, the Fig. 3c legend should have state...
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Open AccessHetero-modification of TRAIL trimer for improved drug delivery and in vivo antitumor activities
Poor pharmacokinetics and resistance within some tumor cell lines have been the major obstacles during the preclinical or clinical application of TRAIL (tumor-necrosis-factor (TNF)-related apoptosis-inducing l...
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Open AccessEffect of Treatment on Body Fluid in Patients with Unilateral Aldosterone Producing Adenoma: Adrenalectomy versus Spironolactone
Aldosterone affects fluid retention in the body by affecting how much salt and water that the kidney retains or excretes. There is limited information about the effect of prolonged aldosterone excess and treat...
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Open AccessNeuromodulation accompanying focused ultrasound-induced blood-brain barrier opening
Burst-mode focused ultrasound (FUS) induces microbubble cavitation in the vasculature and temporarily disrupts the blood-brain barrier (BBB) to enable therapeutic agent delivery. However, it remains unclear wh...
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Open AccessApoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer
TIM-3 functions to enforce CD8+ T cell exhaustion, a dysfunctional state associated with the tolerization of tumor microenvironment. Here we report apoptosis of IFN-γ competent TIM-3+ population of tumor-infil...
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Processing and properties of magnesium containing a dense uniform dispersion of nanoparticles
Magnesium is light but not very strong; here the addition of silicon carbide nanoparticles uniformly dispersed to 14 per cent by volume, achieved through a nanoparticle self-stabilization mechanism in a molten...
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Open AccessCD147 monoclonal antibody mediated by chitosan nanoparticles loaded with α-hederin enhances antineoplastic activity and cellular uptake in liver cancer cells
An antibody that specifically interacts with an antigen could be applied to an active targeting delivery system. In this study, CD147 antibody was coupled with α-hed chitosan nanoparticles (α-Hed-CS-NPs). α-He...
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Open AccessFlame treatment of graphene oxides: cost-effective production of nanoporous graphene electrode for Lithium-ion batteries
A facile production of highly porous graphene foam by using flame treatment of graphene oxide (GO) is proposed. Highly porous architectures with randomly distributed micro-crack and micro-slit were produced du...
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Open AccessPeptides derived from CXCL8 based on in silico analysis inhibit CXCL8 interactions with its receptor CXCR1
Chemokine CXCL8 is crucial for regulation of inflammatory and immune responses via activating its cognate receptor CXCR1. In this study, molecular docking and binding free energy calculations were combined to ...
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Open AccessFTO modulates fibrogenic responses in obstructive nephropathy
Genome-wide association studies have shown that variants in fat mass and obesity-associated (FTO) gene are robustly associated with body mass index and obesity. These FTO variants are also associated with end sta...
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Open AccessGrowing GaN LEDs on amorphous SiC buffer with variable C/Si compositions
The epitaxy of high-power gallium nitride (GaN) light-emitting diode (LED) on amorphous silicon carbide (a-SixC1−x) buffer is demonstrated. The a-SixC1−x buffers with different nonstoichiometric C/Si composition ...
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Open AccessThe role of PD-L1 in the radiation response and clinical outcome for bladder cancer
Identification of potential factors that can stratify a tumor’s response to specific therapies will aid in the selection of cancer therapy. The aim was to highlight the role of programmed cell death 1 ligand 1...
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Open AccessPrognostic role of left atrial strain and its combination index with transmitral E-wave velocity in patients with atrial fibrillation
Left atrial (LA) strain can reflect LA remodeling and is reduced in atrial fibrillation (AF) patients with prior stroke. This study sought to examine the ability of LA strain in predicting subsequent stroke ev...
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Open AccessHuman X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility
In this study, we demonstrate that an E3-ubiquitin ligase associated with human X-linked intellectual disability, CUL4B, plays a crucial role in post-meiotic sperm development. Initially, Cul4bΔ/Y male mice were ...
