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Nanomaterials for Therapeutic Nucleic Acid Delivery

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Handbook of Chemical Biology of Nucleic Acids

Abstract

Nucleic acids and their chemically modified derivatives have gradually become an important class of therapeutic agents. Several nucleic acid-based drugs have been applied to treat various diseases at the genetic level by regulating gene expression and protein translation. Despite these breakthroughs, delivery of nucleic acids to desired tissues and cell populations remains a challenge for clinical translation. To address the delivery issues, researchers have investigated many types of nanomaterials to encapsulate nucleic acids and overcome physiological barriers. Commonly used nanomaterials include polymers, lipids, cell-penetrating peptides (CPPs), inorganic nanomaterials, nucleic acid-based nanoparticles, and viruslike particles (VLPs), several of which have been approved for clinical use. This chapter presents an overview of therapeutic nucleic acids, highlights chemical modification strategies, and introduces representative nanomaterials which may facilitate clinical translation of therapeutic nucleic acids.

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Authors and Affiliations

  1. Division of Pharmaceutics & Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA

    Shi Du, Jeffrey Cheng & Yizhou Dong

  2. Department of Biomedical Engineering, Center for Clinical and Translational Science, Comprehensive Cancer Center, Dorothy M. Davis Heart & Lung Research Institute, Department of Radiation Oncology, Center for Cancer Engineering, Center for Cancer Metabolism, Pelotonia Institute for Immune-Oncology, The Ohio State University, Columbus, OH, USA

    Yizhou Dong

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  1. Shi Du
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  2. Jeffrey Cheng
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Correspondence to Yizhou Dong .

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Editors and Affiliations

  1. Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, Kobe, Japan

    Naoki Sugimoto

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  1. Nankai University, Tian**, China

    Zhen **

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Du, S., Cheng, J., Dong, Y. (2022). Nanomaterials for Therapeutic Nucleic Acid Delivery. In: Sugimoto, N. (eds) Handbook of Chemical Biology of Nucleic Acids. Springer, Singapore. https://doi.org/10.1007/978-981-16-1313-5_100-1

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  • DOI: https://doi.org/10.1007/978-981-16-1313-5_100-1

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