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The Effect of Oxidative Nutritional Products on Cancer

Mechanistic aspects 

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Medical anticancer drugs such as chemotherapy, radiation therapy, and photodynamic therapy kill cancer cells by inducing severe oxidative stress. However, many natural products with antioxidant properties have the ability to increase susceptibility of cancer cells to oxidative stress induced by chemotherapy and radiotherapy by regulating their antioxidant capacity as adjuvants, leading to kill them. In other words, by reducing the antioxidant defense capacity of tumor cells, the ability to balance redox is reduced, leading to cell death. However, depending on the concentration used, cell type, exposure time, and environmental conditions, the same natural compound may exert a pro-oxidant effect, producing activated oxygen and free radicals that cause oxidative damage to DNA. We would like to present a comprehensive list of natural compounds that inhibit the major pro-oxidant defense mechanisms of cancer cells and discuss their potentials of clinical applications.

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Authors and Affiliations

  1. Department of Internal Medicine, General Hospital Minamiseiko Hospital, Nagoya, Japan

    Takehiko Takayanagi

Authors
  1. Takehiko Takayanagi
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Editor information

Editors and Affiliations

  1. Dept Biochem & Biophysics, C-Block, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Department of Internal Medicine, General Hospital Minamiseiko Hospital, Nagoya, Japan

    Takehiko Takayanagi

  2. Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA

    Prakash Radhakrishnan

  3. Department of Nutrition and Dietetics, Faculty of Health Sciences, Bezmialem Vakif University, Istanbul, Turkey

    Ayse Günes-Bayir

  4. Department of Biomedical Sciences, University of Illinois College of Medicine, Rockford, Illinois, USA

    Gnanasekar Munirathinam

  5. Dean, Research, Central University of Punjab, Bathinda, Punjab, India

    Anjana Munsi

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Takayanagi, T. (2022). The Effect of Oxidative Nutritional Products on Cancer. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_253-1

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  • DOI: https://doi.org/10.1007/978-981-16-1247-3_253-1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-16-1247-3

  • Online ISBN: 978-981-16-1247-3

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