Synonyms
Auranofin; Aurocyanide; Chrysotherapy; Dicyanogold (I); Gold complexes; Gold cyanide; Gold salts; Sodium aurothiomalate
Definition
Sodium aurothiomalate and auranofin are gold complexes which have activity in the treatment of rheumatoid arthritis. Several other gold complexes, such as aurothioglucose and gold thiosulphate, have been used in the past but are no longer available. They are in a general class of drugs termed conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). The gold complexes are also included in the general group, slow-acting antirheumatic drugs (SAARDs), because their full clinical effects are produced slowly.
Chemical Structures and Properties
Gold does not form simple salts and only complexes with gold are formed. Sodium aurothiomalate is a polymeric complex in which Au(I) is bound to thiol (-SH) groups (Fig. 1) (Graham et al. 1994). Auranofin (Fig. 2) is monomeric. Au(I) forms complexes with thiol compounds, such as cysteine residues...
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References
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Graham, G.G., Pile, K.D. (2016). Gold Complexes. In: Parnham, M.J. (eds) Compendium of Inflammatory Diseases. Springer, Basel. https://doi.org/10.1007/978-3-7643-8550-7_27
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DOI: https://doi.org/10.1007/978-3-7643-8550-7_27
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