Delirium

  • Living reference work entry
  • First Online:
Encyclopedia of Psychopharmacology
  • 174 Accesses

Synonyms

Acute brain failure; Acute brain syndrome; Acute confusional state; Intensive care unit psychosis; Metabolic encephalopathy

Definition

Delirium is a common and often serious neuropsychiatric complication in the management of medically ill patients. It is associated with increased morbidity and mortality, causing distress in patients, family members, and staff (Breitbart and Alici 2008). It is characterized by an abrupt onset of disturbances of attention or awareness that is accompanied by a change in baseline cognition that cannot be better explained by a preexisting or evolving neurocognitive disorder. The disturbance represents a change from baseline level of attention and awareness and tends to fluctuate in severity during the course of a day. It is a sign of significant physiological disturbance, usually involving multiple medical etiologies, including infection, organ failure, and adverse effects of medication (APA 1999, 2000, 2013).

The Diagnostic and Statistical Manual...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • American Psychiatric Association (1999) Practice guidelines for the treatment of patients with delirium. Am J Psychiatry 156:S1–S20

    Google Scholar 

  • American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Association Press, Washington

    Google Scholar 

  • American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, Arlington

    Google Scholar 

  • Breitbart W, Alici Y (2008) Agitation and delirium at the end of life: “We Couldn’t Manage Him”. JAMA 300:2898–2910

    Article  CAS  PubMed  Google Scholar 

  • Breitbart W, Alici Y (2012) Evidence-based treatment of delirium in patients with cancer. J Clin Oncol 30(11):1206–14. doi: 10.1200/JCO.2011.39.8784. Epub 2012 Mar 12. Review. PMID: 22412123

    Google Scholar 

  • Breitbart W, Friedlander M (2006) Confusion/delirium. In: Bruera E, Higginson I, Ripamonti C, von Gunten C (eds) Palliative medicine. London Hodder Press, London, pp 688–700

    Google Scholar 

  • Candy B, Jackson KC, Jones L, Leurent B, Tookman A, King M (2012) Drug therapy for delirium in terminally ill adult patients. Cochrane Database Syst Rev 11:CD004770. doi:10.1002/14651858.CD004770.pub2

    PubMed  Google Scholar 

  • Casarett DJ, Inouye SK (2001) American College of Physicians-American Society of Internal Medicine End-of-Life Care Consensus Panel. Diagnosis and management of delirium near the end of life. Ann Intern Med 135(1):32–40

    Article  CAS  PubMed  Google Scholar 

  • Elie M, Boss K, Cole MG, McCusker J, Belzile E, Ciampi A (2009) A retrospective, exploratory, secondary analysis of the association between antipsychotic use and mortality in elderly patients with delirium. Int Psychogeriatr 21(3):588–592

    Article  CAS  PubMed  Google Scholar 

  • Inouye SK, Westendorp RG, Saczynski JS (2014) Delirium in elderly people. Lancet 383(9920):911-22. doi: 10.1016/S0140-6736(13)60688-1. Epub 2013 Aug 28. Review. PMID: 23992774

    Google Scholar 

  • Jackson KC, Lipman AG (2006) Drug therapy for delirium in terminally ill patients. Cochrane Database Syst Rev 2:CD004770

    Google Scholar 

  • Lonergan E, Britton AM, Luxenberg J, Wyller T (2007) Antipsychotics for delirium. Cochrane Database Syst Rev 2:CD005594

    PubMed  Google Scholar 

  • Overshott R, Vernon M, Morris J et al (2010) Rivastigmine in the treatment of delirium in older people: a pilot study. Int Psychogeriatr 22:812–818

    Article  PubMed  Google Scholar 

  • Riker RR, Shehabi Y, Bokesch PM, Ceraso D, Wisemandle W, Koura F, Whitten P, Margolis BD, Byrne DW, Ely EW, Rocha MG, SEDCOM (Safety and Efficacy of Dexmedetomidine Compared With Midazolam) Study Group (2009) Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA 301(5):489–499

    Article  CAS  PubMed  Google Scholar 

  • Trzepacz PT (2000) Is there a final common neural pathway in delirium? Focus on acetylcholine and dopamine. Semin Clin Neuropsychiatry 5(2):132–148

    CAS  PubMed  Google Scholar 

  • van Eijk MM, Roes KC, Honing ML et al (2010) Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo controlled randomised trial. Lancet 376:1829–1837

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to William Breitbart .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Breitbart, W., Alici, Y. (2014). Delirium. In: Stolerman, I., Price, L. (eds) Encyclopedia of Psychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27772-6_245-3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-27772-6_245-3

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27772-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Navigation