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Neural Effects on Cardiac Electrophysiology

Interplay Between Beta-Adrenergic Receptors and Ion Channels

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Brain and Heart Dynamics

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Abstract

The interaction between brain and heart involves many actors, among which the sympathetic nervous system plays a major role. Since the first description of adrenoceptors by Raymond Ahlquist in 1948 and the use of beta-blockers by Sir James W. Black in patients with angina pectoris 10 years later, molecular cardiology has been investigating the intimate mechanisms enabling cardiac muscle to adapt (or maladapt) to emotional stress or physical demand. This continuous effort, exploiting state-of-the-art technologies to date, led to an impressive progress in our understanding of the machinery nearby the beta-adrenergic receptor and underneath, much more complex than imagined by pioneering studies of neural-brain axis. This review examines the features of these receptors – subtypes, localization, pathways, and effectors – mediating electrophysiological response of cardiomyocytes, with particular emphasis to control of excitation contraction coupling mechanisms and implications for arrhythmogenesis and cardiomyopathies.

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Author information

Authors and Affiliations

  1. Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy

    Elisabetta Cerbai, Raffaele Coppini, Laura Sartiani & Alessandro Mugelli

Authors
  1. Elisabetta Cerbai
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  2. Raffaele Coppini
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  3. Laura Sartiani
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  4. Alessandro Mugelli
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Corresponding author

Correspondence to Alessandro Mugelli .

Editor information

Editors and Affiliations

  1. Dept of Drug Sciences, Pharmacology Sect, University of Pavia, Dept of Drug Sciences, Pharmacology Sect, Pavia, Pavia, Italy

    Stefano Govoni

  2. Dept of Brain and Behavioural Sciences, University of Pavia Dept of Brain and Behavioural Sciences, Pavia, Pavia, Italy

    Pierluigi Politi

  3. Department of Molecular Medicine, University of Pavia, Department of Molecular Medicine, Pavia, Pavia, Italy

    Emilio Vanoli

Section Editor information

  1. Department of Drug Sciences, Section of Pharmacology, University of Pavia, Pavia, I am not in the U.S. or Canada, Italy

    Alessia Pascale

  2. Dipartimento Cardiovascolare, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy

    Emilia d'Elia

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Cerbai, E., Coppini, R., Sartiani, L., Mugelli, A. (2019). Neural Effects on Cardiac Electrophysiology. In: Govoni, S., Politi, P., Vanoli, E. (eds) Brain and Heart Dynamics. Springer, Cham. https://doi.org/10.1007/978-3-319-90305-7_7-1

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  • DOI: https://doi.org/10.1007/978-3-319-90305-7_7-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-90305-7

  • Online ISBN: 978-3-319-90305-7

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