Clinical Aspects and Investigations in Genitourinary Cancer

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Urologic Oncology

Abstract

Genitourinary cancer is an important topic in the current era. Understanding the disease is important to tailor the treatment for individual patients. Clinical aspects and investigations are part and parcel in cancer diagnosis. Genitourinary cancer encompasses multiple cancers but five important cancers are discussed in this chapter. This includes renal cell carcinoma, prostate cancer, urothelial cancer, testicular cancer and penile cancer. Other subtypes or variants are beyond the scope of this chapter. This chapter is to encourage the readers to better understand the clinical aspects and investigations that are commonly used in genitourinary cancer.

Investigations play a major role in diagnosis of genitourinary cancer. Understanding the principles of the imaging is important to appreciate and interpret a particular imaging modality. The principles of the imaging are mentioned at the start of the chapter. We have placed the clinical aspects and investigations for individual cancers mentioned above and tailored the topics to include appropriate investigations and salient features to take note in the imaging.

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References

  • Afshar-Oromieh A, et al. Comparison of PET imaging with a (68)Ga-labelled PSMA ligand and (18)F-choline-based PET/CT for the diagnosis of recurrent prostate cancer. Eur J Nucl Med Mol Imaging. 2014;41(1):11–20.

    Article  CAS  Google Scholar 

  • Albers P. EAU guidelines on testicular-cancer. 2017 [cited 16 Oct 2017]. Available from http://uroweb.org/guideline/testicular-cancer/.

  • Ascenti G, et al. Contrast-enhanced second-harmonic sonography in the detection of pseudocapsule in renal cell carcinoma. AJR Am J Roentgenol. 2004;182(6):1525–30.

    Article  Google Scholar 

  • Ayyıldız SN, Ayyıldız A. PSA, PSA derivatives, proPSA and prostate health index in the diagnosis of prostate cancer. Turk J Urol. 2014;40(2):82–8.

    Article  Google Scholar 

  • Behesnilian AS, Reiter RE. Risk stratification of prostate cancer in the modern era. Curr Opin Urol. 2015;25(3):246–51.

    Article  Google Scholar 

  • Bonekamp D, et al. Advancements in MR imaging of the prostate: from diagnosis to interventions. Radiographics. 2011;31(3):677–703.

    Article  Google Scholar 

  • Bott S, Patel U, Djavan B, Caroll PR. Images in urology. In: Images in urology. London/New York: Springer; 2012.

    Google Scholar 

  • Brogsitter C, Zophel K, Kotzerke J. 18F-Choline, 11C-choline and 11C-acetate PET/CT: comparative analysis for imaging prostate cancer patients. Eur J Nucl Med Mol Imaging. 2013;40(Suppl 1):S18–27.

    Article  Google Scholar 

  • Brosman SA. Penile cancer. 2015 [cited 16 Oct 2017]. Available from https://emedicine.medscape.com/article/446554-overview.

  • Brown FM. Urine cytology. It is still the gold standard for screening? Urol Clin North Am. 2000;27(1):25–37.

    Article  CAS  Google Scholar 

  • Carroll PR, Parsons JK. Prostate cancer early detection version 2.2016. 2016. Available from https://www.tri-kobe.org/nccn/guideline/urological/english/prostate_detection.pdf.

  • Catalona WJ, Beiser JA, Smith DS. Serum free prostate specific antigen and prostate specific antigen density measurements for predicting cancer in men with prior negative prostatic biopsies. J Urol. 1997;158(6):2162–7.

    Article  CAS  Google Scholar 

  • Catalona WJ, et al. Use of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign prostatic disease: a prospective multicenter clinical trial. JAMA. 1998;279(19):1542–7.

    Article  CAS  Google Scholar 

  • Catalona WJ, et al. A multicenter study of [-2]pro-prostate specific antigen combined with prostate specific antigen and free prostate specific antigen for prostate cancer detection in the 2.0 to 10.0 ng/ml prostate specific antigen range. J Urol. 2011;185(5):1650–5.

    Article  CAS  Google Scholar 

  • De Santis M, et al. 2-18fluoro-deoxy-d-glucose positron emission tomography is a reliable predictor for viable tumor in postchemotherapy seminoma: an update of the prospective multicentric SEMPET trial. J Clin Oncol. 2004;22(6):1034–9.

    Article  Google Scholar 

  • Ferlay J, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–86.

    Article  CAS  Google Scholar 

  • Gouliamos AD. Imaging in clinical oncology. Milano: Springer; 2014.

    Book  Google Scholar 

  • Grover VPB, et al. Magnetic resonance imaging: principles and techniques: lessons for clinicians. J Clin Exp Hepatol. 2015;5(3):246–55.

    Article  Google Scholar 

  • Hacking C, Frank Gaillard A, et al. Transitional-cell-carcinoma-bladder. 2017 [cited 16 Oct 2017]. Available from https://radiopaedia.org/articles/transitional-cell-carcinoma-bladder.

  • Jones J. Testicular cancer. 2017 [cited 16 Oct 2017]. Available from https://radiopaedia.org/articles/testicular-cancer.

  • Kang SK, Kim D, Chandarana H. Contemporary imaging of the renal mass. Curr Urol Rep. 2011;12(1):11–7.

    Article  Google Scholar 

  • Kim JH, et al. Diagnostic accuracy of contrast-enhanced computed tomography and contrast-enhanced magnetic resonance imaging of small renal masses in real practice: sensitivity and specificity according to subjective radiologic interpretation. World J Surg Oncol. 2016;14(1):260.

    Article  Google Scholar 

  • Licklider S. Jewish penile carcinoma. J Urol. 1961;86:98.

    Article  CAS  Google Scholar 

  • Mark Thurston JJ. Bone scan. 2017 [16 October 2017]. Available from https://radiopaedia.org/articles/bone-scan.

  • McNeal JE, et al. Zonal distribution of prostatic adenocarcinoma. Correlation with histologic pattern and direction of spread. Am J Surg Pathol. 1988;12(12):897–906.

    Article  CAS  Google Scholar 

  • Mottet N. Prostate-cancer. 2017 [cited 16 Oct 2017]. Available from http://uroweb.org/guideline/prostate-cancer/.

  • Parkin DM. The global burden of urinary bladder cancer. Scand J Urol Nephrol Suppl. 2008;42(218):12–20.

    Article  Google Scholar 

  • Rauscher I, et al. (68)Ga-PSMA ligand PET/CT in patients with prostate cancer: how we review and report. Cancer Imaging. 2016;16:14.

    Article  Google Scholar 

  • Rouprêt M. EAU guidelines on upper-urinary-tract-urothelial-cell-carcinoma. 2017 [cited 16 Oct 2017]. Available from http://uroweb.org/guideline/upper-urinary-tract-urothelial-cell-carcinoma/.

  • Sachdeva K. Testicular cancer. 2017 [cited 16 Oct 2017]. Available from https://emedicine.medscape.com/article/279007-overview.

  • Smith D, Shetty A. Positron-emission-tomography. 2017 [cited 16 Oct 2017]. Available from https://radiopaedia.org/articles/positron-emission-tomography.

  • Tan LGL, et al. Prospective validation of %p2PSA and the Prostate Health Index, in prostate cancer detection in initial prostate biopsies of Asian men, with total PSA 4–10 ng ml(−1). Asian J Androl. 2017;19(3):286–90.

    Article  CAS  Google Scholar 

  • Verma S, Rajesh A. A clinically relevant approach to imaging prostate cancer: review. AJR Am J Roentgenol. 2011;196(3 Suppl):S1–10; Quiz S11–4.

    Article  Google Scholar 

  • Weinreb JC, et al. PI-RADS prostate imaging – reporting and data system: 2015, version 2. Eur Urol. 2016;69(1):16–40.

    Article  Google Scholar 

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Correspondence to Edmund Chiong .

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Durai, P., Wu, Q.H., Chiong, E. (2019). Clinical Aspects and Investigations in Genitourinary Cancer. In: Merseburger, A., Burger, M. (eds) Urologic Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-42623-5_46

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  • DOI: https://doi.org/10.1007/978-3-319-42623-5_46

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42622-8

  • Online ISBN: 978-3-319-42623-5

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