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Extracellular Matrix Bioactive Molecules and Cell Behavior Modeling

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Handbook of the Extracellular Matrix

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Abstract

The extracellular matrix (ECM) is a multi-functional three-dimensional network of multi-domain proteins that provide biomechanical cues for tissue development and homeostasis. ECM components form a structurally stable tissue composite that renders it mechanical strength. The ECM is also a reservoir of growth factors and biomolecules that control fundamental cellular and biological processes such as proliferation, differentiation, apoptosis, and angiogenesis. Additionally, the ECM harbors a reservoir of growth factors and bioactive molecules that regulate various cellular processes such as cell attachment, motility, proliferation, differentiation, and cell death. Understanding the regulation of ECMs and the mechanisms of ECM remodeling is important for studying pathological processes, develo** new therapeutic interventions for diseases, and for engineering tissues. In this chapter, we will describe the cell-binding motifs and the bioactive molecules in the ECM, along with the resulting effects on cellular function and biology.

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Acknowledgments

This work was supported in part by grants to N.F.H. from the US National Institutes of Health (R01 HL127113, R01 HL142718), the National Science Foundation (1829534 and 2227614), the US Department of Veterans Affairs (1I01BX002310 and 1I01BX004259), and the American Heart Association (20IPA35360085 and 20IPA35310731). This work was also supported in part by the Alliance for Regenerative Rehabilitation Research and Training (AR3T), which is supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Neurological Disorders and Stroke (NINDS), and the National Institute of Biomedical Imaging and Bioengineering (NIBIB) of the National Institutes of Health under Award Number P2CHD086843 to N.F.H. This work was also supported in part by the Tobacco Related Disease Research Program (T33IP6580) and the Lipedema Foundation (LF55-22) to N.F.H. N.F.H. is a recipient of a Research Career Scientist award (IK6 BX006309) from the Department of Veterans Affairs. B.P.O. was supported in part by a diversity supplement from the US National Institutes of Health (3R01HL151997-03S1). Figures were created using BioRender. This publication was made possible by a grant from the US Federal Department of Agriculture (FDA), which supports the University of San Francisco-Stanford Center of Excellence in Regulatory Sciences and Innovation (U01FD005978). The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the US Department of Health and Human Services or FDA.

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Authors and Affiliations

  1. Graver Technologies, Newark, NJ, USA

    Astha Khanna

  2. Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA

    Beu P. Oropeza, Ishita Jain & Ngan F. Huang

  3. Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA

    Beu P. Oropeza, Ishita Jain & Ngan F. Huang

  4. Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA

    Beu P. Oropeza, Ishita Jain & Ngan F. Huang

  5. Department of Chemical Engineering, Stanford University, Stanford, CA, USA

    Ngan F. Huang

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  1. Astha Khanna
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  2. Beu P. Oropeza
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  3. Ishita Jain
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  4. Ngan F. Huang
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Correspondence to Ngan F. Huang .

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Editors and Affiliations

  1. 3B’s Research Group, University of Minho, Barco, Portugal

    Fatima Raquel Azevedo Maia

  2. 3B's Research Group, University of Minho, Guimarães, Portugal

    J. Miguel Oliveira

  3. Dept Polymer Engg, 3Bs Research Grp, University of Minho, Guimaraes, Portugal

    Rui L. Reis

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Khanna, A., Oropeza, B.P., Jain, I., Huang, N.F. (2023). Extracellular Matrix Bioactive Molecules and Cell Behavior Modeling. In: Maia, F.R.A., Oliveira, J.M., Reis, R.L. (eds) Handbook of the Extracellular Matrix. Springer, Cham. https://doi.org/10.1007/978-3-030-92090-6_4-1

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  • DOI: https://doi.org/10.1007/978-3-030-92090-6_4-1

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  • Print ISBN: 978-3-030-92090-6

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