Definition
Intravenous bolus and intravenous infusion are the two ways in which a parenteral drug solution can be administered directly into a patient’s vein. A bolus is a rapid injection, typically within seconds or a few minutes, of a solution into a vein. An IV infusion, on the contrary, involves administering the drug solution for longer periods of time. While a short infusion can last 10–20 minutes, long infusions can take several hours, even days.
A Matter of Pharmacokinetics
Since they use the same administration route, IV bolus and IV infusion share many common characteristics, among them:
They imply the injection of the drug solution directly into a patient’s vein.
They allow the use of the same pharmaceutical dosage form, i.e., sterile solutions (or dry powders to reconstitute as a sterile solution), of aqueous or predominantly aqueous base (see chapter “I...
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Scioli Montoto, S., Ruiz, M.E. (2022). Intravenous Bolus and Infusion. In: Talevi, A. (eds) The ADME Encyclopedia. Springer, Cham. https://doi.org/10.1007/978-3-030-84860-6_97
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DOI: https://doi.org/10.1007/978-3-030-84860-6_97
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