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Nanocelluloses as a Novel Vehicle for Controlled Drug Delivery

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Handbook of Nanocelluloses

Abstract

Nanocelluloses are an emerging type of natural nanomaterial with great potential in pharmaceutical and biomedical applications. There are four main types of nanocelluloses: spherical cellulose nanoparticles (SCNP), cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and bacterial cellulose (BC), all of which may be produced in suitable amounts at a reasonable cost. They possess unique properties such as biodegradability, recyclability, mechanical strength, low toxicity, and tunable amenability to a surface modification to impart new functionalities for selective targeting. They can be produced naturally from different sources (e.g., cotton, woods, agriculture residues) in adequate quantities, making them ideal materials for biomedical, pharmaceutical, and healthcare applications. Nanocelluloses possess a unique structural arrangement with their surface-exposed hydroxyl group, which can be used as anchoring points to install different targeting moieties to deliver the targeted cell therapeutics. This chapter discussed the uses of nanocelluloses and their composites to manufacture films, membranes, aerogels, hydrogels, and large-scale structures that already control the field of drug loading and release. The large surface area of the generated nanocellulose materials allows the delivery of high therapeutics payload to the targeted cells, minimizing the therapeutics’ undesirable side effects. Owing their properties to the high surface-area-to-volume ratio and the high polymerization of nanocellulose, it has the ability for pharmaceutical distribution systems, which have an excellent loading and binding capability for active pharmaceutical ingredients to monitor the release of drugs.

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Authors and Affiliations

  1. Faculty of Pharmacy, Department of Pharmaceutics and Pharmaceutical Technology, Yarmouk University, Irbid, Jordan

    Alaa A. A. Aljabali, Mohammad A. Obeid, Meriem M. Rezigue & Alaa Alqudah

  2. Departamento de Quimica Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Macul, Santiago, Chile

    Nitin Bharat Charbe

  3. Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia

    Dinesh Kumar Chellappan

  4. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

    Vijay Mishra

  5. School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland

    Dinesh M. Pardhi

  6. Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India

    Harish Dureja

  7. School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur, India

    Gaurav Gupta

  8. University of Petroleum & Energy Studies, Dehradun, Uttarakhand, India

    Parteek Prasher

  9. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, Australia

    Kamal Dua

  10. Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt

    Ahmed Barhoum

  11. School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine, UK

    Murtaza M. Tambuwala

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  1. Alaa A. A. Aljabali
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  12. Kamal Dua
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  13. Ahmed Barhoum
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  14. Murtaza M. Tambuwala
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Corresponding authors

Correspondence to Alaa A. A. Aljabali or Murtaza M. Tambuwala .

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  1. Chemistry Department, Helwan University, Faculty of Science, Cairo, Egypt

    Ahmed Barhoum

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Aljabali, A.A.A. et al. (2021). Nanocelluloses as a Novel Vehicle for Controlled Drug Delivery. In: Barhoum, A. (eds) Handbook of Nanocelluloses. Springer, Cham. https://doi.org/10.1007/978-3-030-62976-2_36-1

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  • DOI: https://doi.org/10.1007/978-3-030-62976-2_36-1

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