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Notch Signaling in Pancreatic Morphogenesis and Pancreatic Cancer Pathogenesis

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Pancreatic Cancer

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Abstract

Notch signaling is the focus of investigation in a large number of laboratories around the world due to its pleiotropic effect in regulating normal development and alterations in cancer. During the last few decades, the scientific community studying this pathway has made significant contributions to our understanding of the cellular role of Notch signaling in regulating proliferation, differentiation, apoptosis, migration, branching morphogenesis, and angiogenesis. Similar to observations with other signaling cascades, such as TGBβ, besides its role in morphogenesis, Notch signaling becomes dysregulated in adult tissue and contributes to the development and maintenance of the cancer phenotype. Elegant studies in this field of research have led to not only the better understanding of the molecules within the pathway but, as a consequence, rational design of drugs that can inhibit Notch signaling with promising results. The study of Notch signaling in the pancreas has dawned on solid ground and has progressed to a better understanding of the pathway at the mechanistic level along with the development of some promising pharmacological antagonists. Thus, investigations in this field are predicted to continue to advance the field of pancreatic cancer research in a significant manner for decades to come.

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Acknowledgments

Work in the authors’ laboratories is supported by funding from the National Institutes of Health DK 52913 (to R.U.) and CA178627 (to G.L.), ChiRhoClin Research Institute, as well as the Mayo Clinic SPORE in Pancreatic Cancer (P50 CA102701).

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Authors and Affiliations

  1. Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA

    Gwen Lomberk

  2. Division of Research, Department of Surgery and Genomic Sciences and Precision Medicine Center (GSPMC), Medical College of Wisconsin, Milwaukee, WI, USA

    Raul Urrutia

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  1. Gwen Lomberk
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  2. Raul Urrutia
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Correspondence to Gwen Lomberk .

Editor information

Editors and Affiliations

  1. Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany

    John P. Neoptolemos

  2. Division of Research Department of Surgery and Genomic Sciences and Precision Medicine Center (GSPMC), Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    Raul Urrutia

  3. Division of Medical Oncology, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA

    James L. Abbruzzese

  4. Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany

    Markus W. Büchler

Section Editor information

  1. Mayo Clinic Cancer Center, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA

    Raul A. Urrutia

  2. Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany

    Markus W. Büchler

  3. Division of Surgery and Oncology, University of Liverpool, Daulby Street, Liverpool, UK

    John Neoptolemos

  4. Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany

    Thilo Hackert

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© 2018 Springer Science+Business Media, LLC, part of Springer Nature

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Lomberk, G., Urrutia, R. (2018). Notch Signaling in Pancreatic Morphogenesis and Pancreatic Cancer Pathogenesis. In: Neoptolemos, J., Urrutia, R., Abbruzzese, J., Büchler, M. (eds) Pancreatic Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7193-0_18

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