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Cholecystokinin-1 Receptor

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Encyclopedia of Signaling Molecules

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Synonyms

CCK(A) receptor; CCK1; CCK-A receptor; CCKA; CCKAR; CCK-AR; Cholecystokinin receptor 1; Cholecystokinin type A receptor; Cholecystokinin-1 receptor; CCK-1 receptor; Peripheral type CCK receptor

Historical Background

The hormone cholecystokinin (CCK) was discovered in 1928 by Ivy and Oldberg, based on its ability to stimulate gallbladder contraction. Fifteen years later, Harper and Raper described a factor capable of stimulating pancreatic exocrine secretion (pancreozymin). When Jorpes and Mutt finally isolated the CCK peptide from porcine duodenum in 1966, it became clear that this single hormone was responsible for both of these classical physiological gastrointestinal regulatory activities. Many years later, in 1992, the receptor mediating these effects was finally identified and characterized as a family A guanine nucleotide-binding protein (G protein)-coupled receptor, the CCK-1 receptor (Liddle 1994). Of interest, the cDNA encoding this receptor was initially cloned and...

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References

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Authors and Affiliations

  1. Department of Molecular Pharmacology and Experimental Therapeutics and Department of Internal Medicine, Division of Gastroenterology, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USA

    Laurence J. Miller

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  1. Laurence J. Miller
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Correspondence to Laurence J. Miller .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Miller, L.J. (2016). Cholecystokinin-1 Receptor. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_273-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_273-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

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