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Synthesis of Bioreducible Polycations with Controlled Topologies

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Nanotechnology for Nucleic Acid Delivery

Part of the book series: Methods in Molecular Biology ((MIMB,volume 948))

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Abstract

Bioreducible polycations, which possess disulfide linkages in the backbone, have appeared as promising gene delivery carriers due to their high stability in extracellular physiological condition and bioreduction-triggered release of genetic materials, as well as reduced cytotoxicity because intracellular cytosol is a reducing environment containing high level of reducing molecules such as glutathione. Here, we describe the syntheses of bioreducible polycations, and the methods for control over their topology are also presented.

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Author information

Authors and Affiliations

  1. CAS Key Lab of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, People’s Republic of China

    Ye-Zi You, Jun-Jie Yan & Zhi-Qiang Yu

  2. Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI, USA

    David Oupicky

Authors
  1. Ye-Zi You
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  2. Jun-Jie Yan
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  3. Zhi-Qiang Yu
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  4. David Oupicky
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Corresponding author

Correspondence to Ye-Zi You .

Editor information

Editors and Affiliations

  1. , Department of Pharmacy, Ludwig-Maximilians-University Munich, Butenandstraße 5-13, Munich, 81377, Germany

    Manfred Ogris

  2. , Department of Pharmaceutical Sciences, Wayne State University, Mack Avenue 259, Detroit, 48201, USA

    David Oupicky

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You, YZ., Yan, JJ., Yu, ZQ., Oupicky, D. (2013). Synthesis of Bioreducible Polycations with Controlled Topologies. In: Ogris, M., Oupicky, D. (eds) Nanotechnology for Nucleic Acid Delivery. Methods in Molecular Biology, vol 948. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-140-0_9

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  • DOI: https://doi.org/10.1007/978-1-62703-140-0_9

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-139-4

  • Online ISBN: 978-1-62703-140-0

  • eBook Packages: Springer Protocols

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