Abstract
The chick anxiety–depression model is a hybrid, dual pharmacological screening assay in which both anxiety and depression present sequentially over a 2 h isolation period. This separation stress paradigm utilizes socially raised domestic fowl chicks, aged 4–6 days posthatch, that are isolated from conspecifics during which distress vocalizations (DVocs) are recorded. DVoc rates during the first 5 min are high and represent the anxiety-like phase; DVoc rates decline over the next 20–30 min to about 50% the initial rate and then stabilize for the remainder of the test session. This last 90 min represents the depression-like phase. These two phases are pharmacologically dissociable in that anxiolytics reduce the rate of DVocs during the anxiety-like phase and antidepressants delay the onset of the depression-like phase by attenuating the decline of DVoc rates.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Willner P (1991) Behavioural models in psychopharmacology. In: Willner P (ed) Behavioral models in psychopharmacology: theoretical, industrial and clinical perspectives. Cambridge University Press, Cambridge, pp 3–18
Sufka K et al (2006) Modeling the anxiety-depression continuum hypothesis in domestic fowl chicks. Behav Pharmacol 17:681–689
Warnick J et al (2009) Modeling the anxiety-depression continuum in chicks. J Psychopharmacol 23:143–156
Sufka K et al (2009) Antidepressant efficacy screening of novel targets in the chick anxiety-depression model. Behav Pharmacol 20:146–154
Warnick J, Wicks W, Sufka K (2006) Modeling anxiety-like states: pharmacological characterization of the chick separation stress paradigm. Behav Pharmacol 17:581–587
Feltenstein M et al (2004) The chick separation stress paradigm: a validation study. Pharmacol Biochem Behav 77:221–226
Feltenstein M, Sufka K (2005) Screening antidepressants in the chick separation stress paradigm. Psychopharmacology 181:153–159
Kessler R et al (1994) Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the national comorbidity survey. Arch Gen Psychiatry 51:8–19
Kessler R et al (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry 62:593–602
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer Science+Business Media, LLC
About this protocol
Cite this protocol
White, S.W., Sufka, K.J. (2012). Chick Anxiety–Depression Screening Model. In: Szallasi, A., Bíró, T. (eds) TRP Channels in Drug Discovery. Methods in Pharmacology and Toxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-095-3_12
Download citation
DOI: https://doi.org/10.1007/978-1-62703-095-3_12
Published:
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-62703-094-6
Online ISBN: 978-1-62703-095-3
eBook Packages: Springer Protocols